Stage II Lung Cancer: Ed's Survivor Story

Patient Info: Ed Ackerman, Male, 60s | Stage II

Follow-up tests and scans showed Ed was cancer-free after lung resection and 4 rounds of chemotherapy for Stage IIA lung cancer.

Cleveland ClinicRead more →

Stage IV lung adenocarcinoma complicated by visceral leishmaniasis during chemotherapy

Patient Info: Anonymized, male, 50s | Stage IV

Biomarkers: EGFR wild-type; ALK negative; ROS negative; PD-L1 negative

Imaging showed progression while maintenance pemetrexed was temporarily interrupted; pemetrexed was then restarted during treatment for visceral leishmaniasis.

PubMed CentralRead more →

ALK-positive lung adenocarcinoma complicated by crizotinib-associated kidney and liver cysts

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: ALK fusion

Metastatic Site: bone

After switching from crizotinib to alectinib, the lung cancer and hilar lymph nodes remained stable at the latest follow-up described.

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Jeff

Patient Info: Jeff, Male | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: brain|bones|lymph nodes

The lung mass shrank, 5 brain lesions and the involved lymph node had no evidence of disease, and Jeff described his condition as stable while continuing osimertinib and bone-strengthening infusions.

Lung Cancer Research FoundationRead more →

Stage III squamous lung cancer complicated by a fatal postoperative bronchopleural fistula

Patient Info: Anonymized, male, 40s | Stage III

He developed a postoperative bronchopleural fistula with pulmonary infection and worsening respiratory failure, and died on December 2, 2020.

PubMed CentralRead more →

Stage III squamous lung cancer with a postoperative bronchopleural fistula successfully repaired

Patient Info: Anonymized, male, 50s | Stage III

After bronchoscopic repair of a postoperative bronchopleural fistula, he was followed for more than 1 year with CT every 3 months and no lung-cancer recurrence.

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Stage III squamous lung cancer with a postoperative bronchopleural fistula that resolved with treatment

Patient Info: Anonymized, male, 60s | Stage III

The postoperative bronchopleural fistula resolved after anti-infective treatment, and serial CT scans showed no lung-cancer recurrence during ongoing follow-up.

PubMed CentralRead more →

Stage III lung adenocarcinoma with a postoperative bronchopleural fistula and no recurrence

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: EGFR, ALK, KRAS, RET and ROS1 negative

After treatment of a postoperative bronchopleural fistula, she was followed for more than 1 year with CT every 3 months and no lung-cancer recurrence.

PubMed CentralRead more →

Stage I lung adenocarcinoma diagnosed alongside follicular lymphoma

Patient Info: Anonymized, male, 60s | Stage I

A 69-year-old man was found to have Stage I lung adenocarcinoma and a separate follicular lymphoma, allowing each cancer to be managed independently.

PubMed CentralRead more →

Rare non-small cell lung cancer with TTF-1 and p40 coexpression and later bone recurrence

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: PD-L1 TPS 60%; ALK negative; ROS1 negative

Metastatic Site: lumbar vertebrae

The cancer recurred in the lumbar vertebrae about 4 months after surgery, and he died from cancer 9 months after the operation.

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BRAF V600E lung adenocarcinoma with a response lasting more than 5 years on dabrafenib and trametinib

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: BRAF ; PD-L1 TPS 100%

Metastatic Site: pleura

More than 5 years after her initial presentation, dabrafenib plus trametinib remained effective with no trend toward tumor progression.

PubMed CentralRead more →

Stage IB squamous lung cancer: SBRT, second primary tumor, and local persistence

Patient Info: Anonymized, Female, 70+

Biomarkers: EGFR wild-type / no EGFR mutations detected

As of April 2024, the second left-lower-lobe primary remained without progression after SBRT, but the original right-lower-lobe tumor site had biopsy-confirmed persistent squamous cell carcinoma 4.3 years after SBRT and required salvage local therapy planning.

PubMed CentralRead more →

Stage I papillary lung adenocarcinoma treated with robotic segmentectomy despite an abnormal pulmonary vein

Patient Info: Anonymized, male, 70+ | Stage I

One year after surgery, there was no lung-cancer recurrence and no respiratory or right-sided heart-failure symptoms.

PubMed CentralRead more →

SMARCA4-deficient undifferentiated lung cancer with pleural disease and later spinal metastasis

Patient Info: Anonymized, male, 40s | Stage IV

Biomarkers: BRCA1 p.S1796 variant; TP53 p.; tumor mutational burden 12.6

Metastatic Site: spine

After chemotherapy and one cycle of nivolumab, a new 4.5 cm spinal metastasis caused cord compression and required surgery; further outpatient treatment was planned.

PubMed CentralRead more →

Stage IV BRAF-mutated lung adenocarcinoma responding to second-line chemo-immunotherapy

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: BRAF exon 15 p.T599dup; PD-L1 5%

Metastatic Site: pleura, pericardium

After progression on BRAF/MEK-targeted therapy, second-line chemo-immunotherapy produced a partial response that was still ongoing after about 1 year of second-line treatment.

PubMed CentralRead more →

ALK-positive lung cancer treated with alectinib throughout pregnancy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: ALK rearrangement / fusion-positive

Metastatic Site: pleura; liver; bone; brain

Alectinib produced a complete radiologic response and maintained intracranial control through pregnancy. She delivered a healthy infant at 37 weeks, with normal development at 26 months.

PubMed CentralRead more →

Stage IV EGFR Non-Small Cell Lung Cancer: Anne's Patient Story

Patient Info: Anne Laporte, Female | Stage IV

Biomarkers: EGFR-mutated; several additional mutations mentioned but not specified

Metastatic Site: Spine; liver; lymph nodes

As of March 2024, Anne was living with Stage IVB EGFR-mutated NSCLC on a clinical trial after progression on Tagrisso, with early signs of decreased tumor burden and major improvement in pain.

The Patient StoryRead more →

EGFR L858R/S768I lung adenocarcinoma with more than 5 years of survival after targeted therapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR L858R and S768I compound mutation

Metastatic Site: bone, brain

He died on August 15, 2022, about 5 years and 4 months after his April 2017 presentation; afatinib had provided more than 3 years of disease control before later bone and brain progression.

PubMed CentralRead more →

Stage IV EGFR Non-Small Cell Lung Cancer: Ashley's Patient Story

Patient Info: Ashley, Female | Stage IV

Biomarkers: EGFR T790M mutation

Metastatic Site: Both lungs / bilateral lung nodules

As of March 2024, Ashley was living with Stage IV EGFR-mutated NSCLC controlled on daily Tagrisso for 43 months, with stable scans but no cancer-free or NED claim.

The Patient StoryRead more →

Stage II lung adenocarcinoma with severe atezolizumab-related myocarditis after surgery

Patient Info: Anonymized, female, 40s | Stage II

Biomarkers: PD-L1 TPS 50%

More than 1 year after atezolizumab was discontinued, there was no recurrence of the lung cancer.

PubMed CentralRead more →

Stage IV ALK Lung Adenocarcinoma: Keegan's Survivor Story

Patient Info: Keegan Murphy, Male, 40s | Stage IV

Biomarkers: ALK fusion mutation

Metastatic Site: Lungs; lymph nodes; ribs/bone; abdomen

As of March 2024, Keegan had gone from Stage IV ALK-positive lung adenocarcinoma with tumors in the lungs, lymph nodes, ribs, and abdomen to no evidence of disease after alectinib and surgery.

MD AndersonRead more →

Metastatic lung cancer responding to pembrolizumab despite multiple immune-related side effects

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: right adrenal gland

Later PET/CT showed no FDG uptake in the primary lung lesion or the right adrenal metastasis after pembrolizumab had been stopped for toxicity.

PubMed CentralRead more →

Stage III squamous lung cancer controlled during treatment while a second pancreatic cancer developed

Patient Info: Anonymized, female, 50s | Stage III

Biomarkers: KRAS exon 2 mutation

She died in March 2022. Her Stage III lung cancer had remained controlled for about 18 months, while a separate pancreatic cancer developed and progressed.

PubMed CentralRead more →

Stage IV lung adenocarcinoma presenting as a painful thigh metastasis

Patient Info: Anonymized, female, 40s | Stage IV

Metastatic Site: right thigh soft tissue/muscle, bilateral iliac bones…

After 9 months of therapy, the lung lesion had a partial response and the painful thigh mass had markedly decreased, although she remained unable to walk.

PubMed CentralRead more →