MSI-H locally advanced right colon cancer: pathologic complete response after oxaliplatin, capecitabine, and immunotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: MSI-H on tumor gene testing

After oxaliplatin, capecitabine, and sindilizumab conversion therapy followed by laparoscopic radical right hemicolectomy, postoperative pathology showed no viable tumor cells and tumor regression grade 0 complete response.

PubMed CentralRead more →

Stage III Colorectal Cancer: James's Survivor Story

Patient Info: James, Male | Stage III

James had Stage IIIC / possible Stage IV rectal cancer with major lymph node involvement and an uncertain liver spot. After chemotherapy, radiation, multiple surgeries, permanent colostomy, and adjuvant chemotherapy, he later reported no evidence of disease.

The Patient StoryRead more →

Metastatic rectal cancer responding well after intensive treatment despite severe chemotherapy complications

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: KRAS exon 4 mutation, BRAF wild-type, PD-L1 CPS 2

Metastatic Site: liver, lung

After more than 14 months of treatment, the primary rectal tumor and most lung metastases had been resected, liver lesions had largely regressed, and he was described as near NED while continuing maintenance capecitabine plus bevacizumab.

PubMed CentralRead more →

Colorectal Cancer: Crystal's Survivor Story

Patient Info: Crystal, Female

Crystal completed limited chemotherapy and multiple major surgeries for colon cancer complicated by bladder involvement and infection risk. She lost her bladder and adapted to ostomy changes. No explicit NED, recurrence, or active-disease status was given.

The Patient StoryRead more →

Stage II Colorectal Cancer: Marc's Survivor Story

Patient Info: Marc Anthony, Male, Under 40 | Stage II

Biomarkers: Lynch syndrome

Marc Anthony had Stage IIA colon cancer treated with surgery alone. He did not need chemotherapy or radiation, later learned he had Lynch syndrome, and continued awareness/surveillance because of hereditary risk.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Esteban's Survivor Story

Patient Info: Esteban Moreno | Stage IV

Biomarkers: Lynch syndrome

After immunotherapy and surgery for Stage IV colorectal cancer, Esteban reported recent scans showing no signs of cancer and described himself as NED.

Fight Colorectal CancerRead more →

Stage IV Colorectal Cancer: Crystal's Survivor Story

Patient Info: Crystal, Female | Stage IV

Metastatic Site: Bladder involvement

As of May 2025, Crystal was living after major surgery for Stage IV colon cancer involving the bladder, with both colostomy and urostomy bags and an emphasis on mental health, support, and quality of life.

The Patient StoryRead more →

Metastatic Colorectal Cancer With NRG1 Fusion Controlled for Years With Afatinib

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: MATN-NRG1 fusion; no KRAS alteration detected

Afatinib controlled her metastatic colorectal cancer for 136 weeks. After resection of the remaining target lesion in September 2022, she remained alive with no progression as of October 2024.

PubMed CentralRead more →

NRG1-Fusion Colorectal Cancer Progressing on Afatinib

Patient Info: Anonymized, female, 70+

Biomarkers: CD74-NRG1 fusion; no KRAS alteration detected

The cancer progressed clinically after 8 weeks on afatinib. She died in November 2021.

PubMed CentralRead more →

Stage IV Colorectal Cancer: Albita's Patient Story

Patient Info: Albita, Female, Under 40 | Stage IV

Biomarkers: Described as wild type; no hereditary genetic marker reported

Metastatic Site: liver

Albita had Stage IV colon cancer with liver metastases. As of April 2025, the only active cancer she described was still in the liver, with 3 spots remaining after chemotherapy, radiation, liver resection, hysterectomy/colon surgery, ileostomy, and ongoing/planned liver-directed treatment.

The Patient StoryRead more →

Rectal cancer recurring years later with perineural spread and distant metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: brain, lung, bone

Despite further chemotherapy, the cancer progressed to the brain, lungs and bones, and she died about 1 year later, approximately 9 years after her initial rectal-cancer treatment.

PubMed CentralRead more →

Stage I Colorectal Cancer: Monica's Survivor Story

Patient Info: Monica Dean, Female, 40s | Stage I

As of April 2025, Monica was disease-free after Stage I colorectal cancer was removed with lower anterior resection; pathology showed clean margins and no lymph node involvement, and she did not need chemotherapy or radiation.

The Patient StoryRead more →

Lynch syndrome bifocal colon cancer: complete pathological remission after sintilimab

Patient Info: Anonymized, Male, 40s | Stage III

Biomarkers: Lynch-associated colon cancer with MSI-H and KRAS/NRAS/BRAF wild type; tumor markers were low or near normal.

As of April 2025, pathology after proximal colectomy showed tumor regression grade 0 with complete pathological remission, and follow-up found no recurrence or metastasis.

PubMed CentralRead more →

Stage II Colorectal Cancer: Monica's Survivor Story

Patient Info: Monica Dean, Female, 40s | Stage II

Biomarkers: No genetic predisposition reported after testing

Monica Dean had Stage II colorectal cancer found by screening colonoscopy. Curative surgery showed clear margins and no lymph node involvement, so she did not need chemotherapy or radiation. As of April 2025, she was recovering with a temporary ileostomy and planning reversal.

The Patient StoryRead more →

Michelle: Stage IV Colorectal Cancer

Patient Info: Michelle, Female, 40s | Stage IV

Metastatic Site: Ovary | Femoral nerve region

As of April 2025, Michelle described living as a Stage IV colorectal cancer survivor after FOLFOX, major surgery, 2.5 years with no evidence of disease, and a later PET-detected recurrence involving the femoral nerve region.

The Patient StoryRead more →

Stage III colon cancer followed by a second gastro-oesophageal adenocarcinoma

Patient Info: Anonymized, Female | Stage III

Biomarkers: KRAS-mutated, NRAS-negative, BRAF-negative

After surgery and 4 cycles of CAPEOX, imaging initially showed no metastases. Later imaging showed new bilobar liver lesions, and a separate primary gastro-oesophageal adenocarcinoma was diagnosed about 1 year after the colon cancer.

PubMed CentralRead more →

Stage IV Colorectal Cancer: Kasey's Patient Story

Patient Info: Kasey, Female, Under 40 | Stage IV

Biomarkers: CEA elevated; no genomic biomarker reported

Metastatic Site: liver

Kasey was diagnosed with Stage II colon cancer in February 2024 and progressed to Stage IV disease with a liver lesion in September 2024. As of April 2025, she was continuing chemotherapy after liver surgery.

The Patient StoryRead more →

Stage III Colorectal Adenocarcinoma: Chloe's Survivor Story

Patient Info: Chloe, Female | Stage III

Biomarkers: Familial adenomatous polyposis

As of April 2025, Chloe was in remission after emergency surgery with a stoma and 4 rounds of IV/oral chemotherapy for Stage III FAP-associated colon adenocarcinoma.

The Patient StoryRead more →

Cardiac arrest during rectal cancer surgery caused by an anal-cardiac reflex

Patient Info: Anonymized, Male, 50s

The operation was completed after successful resuscitation from two intraoperative cardiac arrests, and he had no related cardiac-arrest sequelae during the following year.

PubMed CentralRead more →

Stage III Colorectal Cancer: Chloe's Survivor Story

Patient Info: Chloe, Female, Under 40 | Stage III

Biomarkers: Rare genetic disorder/gene reported; exact gene not stated

Chloe was diagnosed with Stage III colon cancer in February 2024 after emergency surgery. After surgery, stoma creation, and 3 months of chemotherapy, she was told she was in remission in June 2024 and remained on surveillance.

The Patient StoryRead more →

Stage II Colorectal Cancer: Kristin's Survivor Story

Patient Info: Kristin, Female | Stage II

Kristin had Stage II colon cancer treated with emergency surgery and 4 months of chemotherapy. Her February 2022 scan confirmed no evidence of disease, and as of March 2025 she had recently celebrated 3 years cancer-free.

The Patient StoryRead more →

Mark: Stage III Colorectal Cancer

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Lynch syndrome negative

As of March 2025, Mark was sharing his story after surgery and intensive chemotherapy for Stage IIIB colon cancer and had been declared to have no evidence of disease in 2021.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Bill's Patient Story

Patient Info: Bill, Male, 40s | Stage IV

Metastatic Site: Liver | Lungs | Brain

As of March 2025, Bill was living with incurable Stage IV colon cancer after liver, lung, and brain involvement, with ongoing chemotherapy and lifelong maintenance treatment.

The Patient StoryRead more →

Stage III Colorectal Cancer: Heather's Survivor Story

Patient Info: Heather Russell, Female, Under 40 | Stage III

In her fifth year of remission at the time of the 2025 story after treatment for Stage III rectal cancer; she had returned to family and working life, with some lasting treatment effects.

Cleveland ClinicRead more →