KRAS Mutation Colorectal Cancer: 12 Real Stories

12 stories match colorectal cancer and KRAS mutation. 11 of them mention chemotherapy.

Cancer Stories

A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Stage IV MSI-H KRAS-mutant colorectal adenocarcinoma: severe pembrolizumab-associated hypercalcemia resolved with steroids and zoledronic acid

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: KRAS G12xa mutation; MSI-H; BRAF wild type; NRAS wild type; PTH low-normal

Metastatic Site: liver

After the second pembrolizumab dose, severe hypercalcemia and electrolyte abnormalities resolved with high-dose glucocorticoids, zoledronic acid, and supportive care; cancer response was not yet described.

PubMed Central
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

PubMed Central
OutcomeCancer-Free / NED
Bill, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV KRAS Colorectal Cancer: Bill's Patient Story

Patient Info: Bill, Male, 40s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver; lung; brain

Bill has Stage IV KRAS G12A-mutated colon cancer with liver, lung, and brain metastases. After multiple surgeries, ablation, Gamma Knife, and repeated chemotherapy, tumors shrank and he moved to lifelong maintenance chemotherapy every 2 weeks as of March 2025.

The Patient Story
OutcomeLiving With Cancer
Lauren, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV KRAS Colorectal Cancer: Lauren's Patient Story

Patient Info: Lauren Bimage, Female, Under 40 | Stage IV

Biomarkers: Patient-reported KRAS-mutated colon cancer

Metastatic Site: chest; abdominal/peritoneal lining; spine/back

As of September 2024, Lauren was living with both Stage IV breast cancer and Stage IV colon cancer. Colon cancer markers were described as low/normal, while biopsy showed the persistent back/spine disease was breast cancer.

The Patient Story
OutcomeLiving With Cancer
Kris, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV KRAS Colorectal Cancer: Kris's Patient Story

Patient Info: Kris Sokolowski, Male, 40s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: Liver; sternum; spine; lymph nodes; omentum/abdominal…

As of May 2022, Kris was living with Stage IV KRAS G13D-mutant colorectal cancer. Most tumors had been stable or shrinking, but abdominal/omental disease continued to grow despite additional full-strength chemotherapy, so clinical-trial and immunotherapy options were being explored.

MD Anderson
OutcomeSetback / Progression
A patient, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Severe immune thrombocytopenia during treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: KRAS-mutated; microsatellite stable; BRAF-wild type.

Metastatic Site: bilateral ovaries; pelvis; peritoneum; mesenteric…

After multiple metastatic recurrences and treatment changes, she died from progressive colon cancer; oxaliplatin had been permanently stopped after antibody-confirmed immune thrombocytopenia.

PubMed Central
OutcomeIn Memory
A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Metastatic Right-Sided Colon Cancer With an NRG1 Fusion

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS mutation; POMK-NRG1 fusion

Metastatic Site: liver|lungs

He had persistent metastatic disease after 16 months of afatinib and entered a phase I trial in January 2020.

PubMed Central
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Treatment-Related Inflammation Mimicked Metastatic Colon Cancer Recurrence

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver|peritoneum

Biopsy showed that new lymph-node, liver, and spleen findings were a treatment-related sarcoid-like reaction rather than recurrence, and 18 months of surveillance found no evidence of cancer.

PubMed Central
OutcomeCancer-Free / NED
A patient, who was diagnosed with Colorectal AdenocarcinomaColorectal Cancer

Colon Cancer Metastasis Found Inside a Thyroid Nodule

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: KRAS mutated; thyroid metastasis CDX2 positive and CK20 positive; PAX8/TG/TTF-1 negative

Metastatic Site: lungs|thyroid

Follow-up was planned after thyroid surgery, with no adjuvant treatment for the coexisting low-risk thyroid lesion.

PubMed Central
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Metastatic Colon Cancer With KRAS, NRAS, and BRAF Mutations

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS exon 3 ; NRAS exon 2 ; BRAF exon 10 ; PIK3CA exon 2 .

Metastatic Site: liver

The liver metastases progressed despite FOLFOX and bevacizumab, and he died within one year of the initial diagnosis.

PubMed Central
OutcomeIn Memory