Colorectal Cancer: Lisa's Survivor Story

Patient Info: Lisa Roth, Female, 50s

Biomarkers: Lynch syndrome / HNPCC

By winter 2012/2013, Lisa was free of metastases and recurrence after surgery for Lynch syndrome-associated colorectal cancer, and she had become active in hereditary colorectal cancer self-help.

Krankheitserfahrungen.deRead more →

Colorectal Cancer: Danny's Survivor Story

Patient Info: Danny Soto, Male | Stage Metastatic/Advanced

Biomarkers: Lynch syndrome

Danny became cancer-free with no evidence of disease after extensive surgery and intraoperative radiation for complex colon cancer, and returned to work as a firefighter with follow-up visits every 6 months.

Memorial Sloan KetteringRead more →

Stage IV MSI-High Colorectal Cancer: JJ's Patient Story

Patient Info: JJ, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome; microsatellite instability

Metastatic Site: Abdominal wall; lymph nodes throughout the body

At the latest scan, the main abdominal tumor remained stable. JJ had completed 126 rounds of chemo-immunotherapy and continued treatment every 3 weeks; small lung nodules were being watched but were not confirmed as metastases.

The Patient StoryRead more →

Stage III Colorectal Cancer: Zed's Survivor Story

Patient Info: Zed, Male, Under 40 | Stage III

Biomarkers: Lynch syndrome

As of June 2026, Zed had completed colectomy and chemotherapy and was in surveillance with no evidence of disease. Lynch syndrome was also identified, supporting stricter long-term surveillance.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Jackie's Patient Story

Patient Info: Jackie, Female | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Not reported

Jackie’s Stage IIIB rectal cancer later recurred as Stage IV/metastatic disease, but early immunotherapy response was strong, with no visible tumor on MD Anderson sigmoid scope about 6 weeks after starting treatment.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Mike's Patient Story

Patient Info: Mike Ray, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Liver

As of March 2026, Mike had recovered quickly from a May 2025 liver transplant after about 2.5 years of cancer-control treatment for liver-metastatic colon cancer with Lynch syndrome, and he had returned to running, weight training, and triathlon goals.

Cleveland ClinicRead more →

Stage III MSI-High Colorectal Cancer: Tommy's Survivor Story

Patient Info: Tommy Allen, Male, 50s | Stage III

Biomarkers: MSI-high; Lynch syndrome

As of November 2025, Tommy was cancer-free 5 years after pembrolizumab, ileostomy, Whipple procedure, partial colectomy, and ileostomy closure for Stage III MSI-high colon cancer with Lynch syndrome.

MD AndersonRead more →

Stage I Colorectal Cancer: Jessica's Survivor Story

Patient Info: Jessica, Female, Under 40 | Stage I

Biomarkers: Lynch syndrome

Jessica had Stage I Lynch syndrome-associated rectal cancer treated with an immunotherapy clinical-trial approach rather than chemoradiation or surgery. Midpoint colonoscopy and MRI showed the mass was gone, and she completed 7 infusions over 6 months. As of September 2025, she was in survivorship with intensive Lynch syndrome surveillance.

The Patient StoryRead more →

Stage II Colorectal Cancer: Marc's Survivor Story

Patient Info: Marc Anthony, Male, Under 40 | Stage II

Biomarkers: Lynch syndrome

Marc Anthony had Stage IIA colon cancer treated with surgery alone. He did not need chemotherapy or radiation, later learned he had Lynch syndrome, and continued awareness/surveillance because of hereditary risk.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Esteban's Survivor Story

Patient Info: Esteban Moreno | Stage IV

Biomarkers: Lynch syndrome

After immunotherapy and surgery for Stage IV colorectal cancer, Esteban reported recent scans showing no signs of cancer and described himself as NED.

Fight Colorectal CancerRead more →

Lynch syndrome bifocal colon cancer: complete pathological remission after sintilimab

Patient Info: Anonymized, Male, 40s | Stage III

Biomarkers: Lynch-associated colon cancer with MSI-H and KRAS/NRAS/BRAF wild type; tumor markers were low or near normal.

As of April 2025, pathology after proximal colectomy showed tumor regression grade 0 with complete pathological remission, and follow-up found no recurrence or metastasis.

PubMed CentralRead more →

Maddee: Stage II Colorectal Cancer

Patient Info: Maddee, Female | Stage II

Biomarkers: Lynch syndrome

As of October 2024, Maddee was in surveillance after surgery for Stage II Lynch syndrome-associated colon cancer, with about 1 foot of colon and 40 lymph nodes removed and no chemotherapy given.

The Patient StoryRead more →

Stage II Colorectal Cancer: Maddee's Survivor Story

Patient Info: Maddee Moore, Female, Under 40 | Stage II

Biomarkers: Lynch syndrome

As of October 2024, Maddee had no reported recurrence after surgery for Stage II colon cancer and remained in close surveillance because of Lynch syndrome.

The Patient StoryRead more →

Colorectal Cancer: Jay's Patient Story

Patient Info: Jay Reese, Under 40

Biomarkers: Lynch syndrome

After a full colectomy in February 2012, Jay did not need further surgery, radiation, or chemotherapy and continued close surveillance because of Lynch syndrome.

Dana-FarberRead more →

MSI-High Colorectal Cancer: Stephanie's Patient Story

Patient Info: Stephanie Dobson, Female, Under 40

Biomarkers: MSI-high; Lynch syndrome

The rectal tumor was shrinking on immunotherapy and early treatment-related fatigue was improving.

Dana-FarberRead more →

Stage II MSI-High Colorectal Cancer: Shannon's Survivor Story

Patient Info: Shannon, Female, Under 40 | Stage II

Biomarkers: MSI-H; Lynch syndrome; MLH1 mutation

As of October 2023, Shannon had no recurrence described while approaching year 5 after Stage IIA colon cancer surgery and continued intensive Lynch syndrome surveillance.

The Patient StoryRead more →

Stage III Colorectal Cancer: Amy's Survivor Story

Patient Info: Amy, Female, Under 40 | Stage III

Biomarkers: Lynch syndrome

As of April 2023, Amy had no evidence of disease after Stage IIIB Lynch syndrome-associated colorectal cancer treatment, with clear scans/tumor-residue testing and ongoing Lynch syndrome surveillance.

The Patient StoryRead more →

Stage III MSI-High Colorectal Cancer: Amy's Patient Story

Patient Info: Amy Hart, Female, Under 40 | Stage III

Biomarkers: Lynch syndrome; tumor described as Lynch-related but not MSI-high

As of March 2023, Amy’s story described Stage IIIB colorectal/rectal cancer diagnosis, Lynch syndrome confirmation, rapid start of daily radiation, and major surgery planning; no completed-treatment, recurrence, NED, or cancer-free status was stated.

The Patient StoryRead more →

I was in Disbelief When I got Colon Cancer

Patient Info: JJ Singleton, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Abdominal wall; lymph nodes

After surgery and 12 rounds of FOLFOX, JJ had a clean scan and colonoscopy, but about 6 weeks later cancer recurred outside the colon with spread to the abdominal wall and lymph nodes.

The Patient StoryRead more →

Colorectal Cancer: Wenora's Patient Story

Patient Info: Wenora Johnson, Female, 50s

Biomarkers: Lynch syndrome

Wenora remained on maintenance anticancer treatment and regular surveillance after her 2011 colorectal cancer diagnosis.

Colorectal Cancer: Alejandro's Patient Story

Patient Info: Alejandro Mirazo, Male

Biomarkers: Lynch syndrome

Alejandro recovered quickly from colon surgery and had started a planned 4-cycle course of chemotherapy by May 2022, with ongoing surveillance for recurrence and other Lynch syndrome-associated cancers.

Rectal Cancer in His Late 20s Revealed Lynch Syndrome

Patient Info: Anonymized, Male

Biomarkers: Rectal tumor lacked MSH2 and MSH6 expression; germline MSH2 c.2459-12A>G likely pathogenic splice variant identified by DNA and RNA testing

After the inherited MSH2 variant was confirmed, he entered intensive Lynch syndrome surveillance with annual colonoscopy. No additional cancers had been identified in the carriers at the latest family update.

PubMed CentralRead more →

Colon Cancer in Her 30s Led to a Lynch Syndrome Diagnosis

Patient Info: Anonymized, Female

Biomarkers: Germline MSH2 c.2458+976A>G likely pathogenic deep intronic splice variant identified by concurrent DNA and RNA testing

Colon cancer and triple-negative breast cancer in a woman in her mid-30s prompted RNA testing that uncovered a deep intronic MSH2 Lynch syndrome variant.

PubMed CentralRead more →

Colon cancer at age 27 in a man later diagnosed with Lynch syndrome

Patient Info: Anonymized, Male, Under 40

Biomarkers: Germline pathogenic MSH2 variant NM_000251.2:c.942+3A>T identified later

The first colon cancer remained disease-free after partial colectomy and adjuvant chemotherapy; years later, he died after decline from metastatic pheochromocytoma.

PubMed CentralRead more →