Hepatectomy for Colorectal Cancer: 9 Real Stories

Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

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Stage IV sigmoid colon cancer: recurrence after FOLFOX, hepatectomy, and colectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Mismatch repair proficient; microsatellite stable; KRAS wild-type; BRAF wild-type; CEA 3.8 ng/mL at diagnosis

Metastatic Site: liver, lung

As of September 2025, metastatic sigmoid colon cancer had recurred in the lungs and remnant liver after initial FOLFOX, hepatectomy, and colectomy, requiring FOLFIRI plus cetuximab.

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Stage IV Colorectal Cancer: Shayla's Patient Story

Patient Info: Shayla, Female, Under 40 | Stage IV

Metastatic Site: Liver

As of February 2025, Shayla was in ongoing treatment for Stage IV colorectal cancer with liver metastasis after 4 rounds of chemotherapy, liver resection, and resumed chemotherapy.

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Rectal Cancer Relapse With a Rare Kidney Metastasis

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: liver; peritoneum; right kidney

After earlier treatment and a hepatectomy, imaging showed recurrent rectal disease with pelvic and peritoneal involvement and a new right kidney metastasis.

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My Stage 4 Colorectal Cancer Story: How I Never Lost Hope

Patient Info: Jason Randall, Male | Stage IV

Metastatic Site: Liver; lungs; bone/sacrum

As of June 2023, Jason had a negative Signatera test, CT scans showing 9 months with no evidence of disease, and about 2.5 years off chemotherapy after Stage IV colorectal cancer treatment and lung ablation.

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Stage IV Colorectal Cancer: Bart's Survivor Story

Patient Info: Bart Wilson, Male, Under 40 | Stage IV

Metastatic Site: Liver

As of May 2023, Bart had shown no evidence of disease for almost 3 years after surgery, FOLFOX, portal vein embolization, extended right hepatectomy, and adjuvant capecitabine for Stage IV colon cancer with liver metastases.

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Rectal cancer liver surgery in a woman with mitochondrial disease

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: liver; lungs; para-aortic lymph nodes

Three months after rectal and liver surgery, CT showed multiple lung metastases and para-aortic lymph-node metastasis, and FOLFIRI chemotherapy was resumed.

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Treatment-Related Inflammation Mimicked Metastatic Colon Cancer Recurrence

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver|peritoneum

Biopsy showed that new lymph-node, liver, and spleen findings were a treatment-related sarcoid-like reaction rather than recurrence, and 18 months of surveillance found no evidence of cancer.

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Bloodstream Infection in a Man With Metastatic Colorectal Cancer

Patient Info: Anonymized, male, 70+

He was living with colorectal cancer involving the liver and peritoneum after multiple chemotherapy courses and liver surgery.

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