Stage III MSI-High Colorectal Cancer: Tommy's Survivor Story

Patient Info: Tommy Allen, Male, 50s | Stage III

Biomarkers: MSI-high; Lynch syndrome

As of November 2025, Tommy was cancer-free 5 years after pembrolizumab, ileostomy, Whipple procedure, partial colectomy, and ileostomy closure for Stage III MSI-high colon cancer with Lynch syndrome.

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Stage IV Colorectal Cancer: Rylie's Patient Story

Patient Info: Rylie, Female, Under 40 | Stage IV

Metastatic Site: liver

Rylie was recovering from emergency surgery, adapting to an ostomy, and preserving fertility after a new Stage IV colon cancer diagnosis; systemic treatment response was not stated.

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Colorectal Cancer: Donna's Survivor Story

Patient Info: Donna Marie Caruso, Female, 70+

As of November 2025, Donna was in rectal cancer survivorship after surgery, radiation and chemotherapy, with improved quality of life through support for low anterior resection syndrome; no formal stage or NED status was stated.

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Teenage colorectal cancer: Stage III signet-ring adenocarcinoma and 10-year disease-free follow-up after FOLFOX

Patient Info: Anonymized, Female, Under 40 | Stage III

Biomarkers: CDX2-positive; CK7-positive; AE1-AE3-positive; signet-ring cell adenocarcinoma histology

As of November 2025, she was disease-free 10 years after laparoscopic right hemicolectomy with clear margins and 6 months of adjuvant FOLFOX for T4N2Mx signet-ring colon adenocarcinoma.

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Stage IV Colorectal Cancer: Kailee's Patient Story

Patient Info: Kailee, Female, Under 40 | Stage IV

Metastatic Site: liver; lungs

Kailee was living with Stage IV colorectal cancer, caring for 2 young daughters, and continuing active treatment after receiving 4 rounds of chemotherapy during pregnancy.

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Rectal Cancer Found After Unexplained E. coli Bacteremia and Septic Arthritis

Patient Info: Anonymized, female, 60s

At 1 year of follow-up, the rectal cancer had not recurred.

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Colon cancer patient with insulin autoimmune syndrome after FOLFOX, bevacizumab, and omeprazole

Patient Info: Anonymized, Male, 70+

Biomarkers: No cancer biomarkers reported. Insulin autoimmune syndrome followed chemotherapy/omeprazole exposure.

As of November 2025, the rare insulin autoimmune syndrome episode had improved after glucose supplementation and prednisone acetate, with blood glucose returning to the normal range during postoperative colon cancer treatment.

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Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

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Stage I low rectal adenocarcinoma: ileal J-pouch salvage reconstruction after rectovaginal fistula

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: CEA remained within normal range during follow-up; no molecular biomarkers reported

At 5 years after salvage reconstruction, colonoscopy showed no recurrence, stricture, or pouch complication; annual CT showed no local recurrence or distant metastasis; CEA remained normal and bowel function was satisfactory.

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Stage IV BRAF Colorectal Adenocarcinoma: Pio's Patient Story

Patient Info: Pio, Male, 50s | Stage IV

Biomarkers: BRAF V600 mutation

Metastatic Site: peritoneum; liver; left lung nodules

After initial chemotherapy produced mixed results and May imaging showed growth, BRAF/EGFR-directed treatment led to a marked improvement on July scans.

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Stage III dMMR transverse colon cancer: colectomy and adjuvant FOLFOX with no recurrence on CT

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: Loss of MLH1 and PMS2; BRAF mutation; MMR-deficient colorectal cancer

After colectomy and initiation of planned adjuvant FOLFOX, surveillance abdominal CT showed no recurrence or metastasis.

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Resected Stage IV colorectal cancer: no recurrence during xeligekimab treatment for psoriasis and hidradenitis suppurativa

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: No colorectal molecular biomarkers reported. CEA slightly high at follow-up; HBV DNA stayed suppressed on antiviral treatment.

Metastatic Site: liver

Six years after colorectal cancer surgery with liver-metastasis resection, surveillance showed no recurrence; during 28 weeks of xeligekimab follow-up, imaging and tumor markers showed no tumor progression.

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Stage IV Colorectal Cancer: Starr's Survivor Story

Patient Info: Starr, Female, 40s | Stage IV

Metastatic Site: Liver; peritoneum; lymph nodes

Starr had Stage IV colon cancer involving the liver, peritoneum, and lymph nodes. After chemotherapy, targeted therapy, and 2 surgeries in early 2025, she was told scans and circulating-tumor testing showed no visible cancer. As of October 2025, she described being in remission.

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The Cancer Spread One Year Later…

Patient Info: Kalei, Female, Under 40 | Stage IV

Metastatic Site: Lungs; bilateral lung nodules

Kalei initially had Stage II rectal cancer that responded to chemoradiation and IV chemotherapy without rectal surgery. In 2025, biopsy-proven lung metastasis changed the diagnosis to Stage IV. As of October 2025, she had undergone lung resections with clear margins and remained in ongoing follow-up rather than having a clearly stated NED status.

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Stage II Colorectal Adenocarcinoma: Ali's Survivor Story

Patient Info: Ali, Female, Under 40 | Stage II

Ali completed 8 chemotherapy treatments after delivering her daughter by C-section at 35 weeks. A January 2025 scope and biopsy confirmed remission, and later MRI, scope, and colonoscopy surveillance were good. As of October 2025, she remained on close watch-and-wait surveillance.

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Kidney complication after switching colorectal cancer chemotherapy regimens

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver

The cancer had worsening liver metastases when FTD/TPI began. After treatment was stopped, steroid therapy resolved edema within 1 month and proteinuria returned to baseline 2.5 months after admission; the later cancer course was not established.

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Stage IV sigmoid colon cancer: recurrence after FOLFOX, hepatectomy, and colectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Mismatch repair proficient; microsatellite stable; KRAS wild-type; BRAF wild-type; CEA 3.8 ng/mL at diagnosis

Metastatic Site: liver, lung

As of September 2025, metastatic sigmoid colon cancer had recurred in the lungs and remnant liver after initial FOLFOX, hepatectomy, and colectomy, requiring FOLFIRI plus cetuximab.

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Stage I Colorectal Cancer: Jessica's Survivor Story

Patient Info: Jessica, Female, Under 40 | Stage I

Biomarkers: Lynch syndrome

Jessica had Stage I Lynch syndrome-associated rectal cancer treated with an immunotherapy clinical-trial approach rather than chemoradiation or surgery. Midpoint colonoscopy and MRI showed the mass was gone, and she completed 7 infusions over 6 months. As of September 2025, she was in survivorship with intensive Lynch syndrome surveillance.

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Stage IV BRAF Colorectal Cancer: Jackson's Patient Story

Patient Info: Jackson, Male, Under 40 | Stage IV

Biomarkers: BRAF mutation

Metastatic Site: Liver; peritoneal wall

Jackson had Stage IV BRAF-mutated colon cancer with extensive liver disease and later confirmed peritoneal-wall tumors. His treatment response was strong, with about 90% of liver disease estimated gone, but he remained on active treatment with possible future HIPEC evaluation. As of September 2025, he was responding well but not cancer-free.

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Stage IV Colorectal Cancer: Laura's Patient Story

Patient Info: Laura VanBrocklin, 40s | Stage IV

Metastatic Site: liver

After multiple procedures and surgery for Stage IV colorectal cancer with liver involvement, Laura was still finishing chemotherapy.

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Stage IV Colorectal Cancer: Heather's Patient Story

Patient Info: Heather Candrilli, Female, Under 40 | Stage IV

Metastatic Site: Liver

Heather had Stage IV colon cancer with liver-only metastases. Her scans improved and Signatera became negative, but she still had many liver lesions and was not considered resectable. As of September 2025, she remained on chemotherapy while pursuing living-donor liver transplant evaluation.

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Stage IV transverse colon cancer with NTRK fusion: entrectinib response followed by fatal PTTM

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: RAS/BRAF wild type, low TMB. CEA and CA19-9 were elevated before entrectinib and fell with response.

Metastatic Site: peritoneum, greater omentum, pleura,…

He died 7 weeks after hospitalization from pulmonary tumor thrombotic microangiopathy causing severe pulmonary hypertension and right-heart failure, despite biochemical and ascites response to entrectinib.

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Stage III Colorectal Cancer: Kara's Survivor Story

Patient Info: Kara Lionetta, Female | Stage III

An update to Kara's story reported that she was no evidence of disease while completing cleanup chemotherapy and planning later ileostomy reversal.

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Stage IV Colorectal Cancer: Claire's Patient Story

Patient Info: Claire, Female, 40s | Stage IV

Metastatic Site: Abdominal wall; lungs

As of September 2025, Claire was living with metastatic recurrent colorectal cancer as a chronic illness, receiving chemotherapy every 2 weeks since April 2018, approaching her 200th round, and maintaining stable disease with no signs of growth.

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