Stage IV Colorectal Cancer: Ken's Patient Story

Patient Info: Ken, Male, 50s | Stage IV

Metastatic Site: Liver

As of May 2026, Ken was more than 3 years into Stage IV colorectal cancer. He was not cancer-free or NED, but described the disease as minimal and manageable with surveillance, maintenance chemotherapy/targeted therapy, and occasional ablation.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Helen's Survivor Story

Patient Info: Helen, Female, 40s | Stage IV

Metastatic Site: Liver; pelvis

No active tumors / no evidence of disease after liver-directed treatment, liver surgery/ablation, colon resection, and hysterectomy, though she personally described herself as living with cancer and still planned cleanup treatment.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Joe's Patient Story

Patient Info: Joe, Male | Stage IV

Biomarkers: Specific biomarkers not reported

Metastatic Site: Liver; lymph nodes; lungs

Stage IV colon cancer initially reached no evidence of disease after FOLFOX plus panitumumab, but later recurred in the liver and lymph nodes, progressed to the lungs, and did not respond to later FOLFOX rechallenge or FOLFIRI before he started an immunotherapy clinical trial.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Alyssa's Patient Story

Patient Info: Alyssa Kelly, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

More than 4 years after pregnancy-associated Stage IV colorectal cancer, Alyssa was alive with her son, but after more than 1 year off chemotherapy she had several lung tumors, restarted chemotherapy, and was looking into clinical trials.

City of HopeRead more →

Stage IV BRAF Colorectal Cancer: Jackson's Patient Story

Patient Info: Jackson, Male, Under 40 | Stage IV

Biomarkers: BRAF mutation

Metastatic Site: Liver; peritoneal wall

Jackson had Stage IV BRAF-mutated colon cancer with extensive liver disease and later confirmed peritoneal-wall tumors. His treatment response was strong, with about 90% of liver disease estimated gone, but he remained on active treatment with possible future HIPEC evaluation. As of September 2025, he was responding well but not cancer-free.

The Patient StoryRead more →

Stage IV Colorectal Cancer: Heather's Patient Story

Patient Info: Heather Candrilli, Female, Under 40 | Stage IV

Metastatic Site: Liver

Heather had Stage IV colon cancer with liver-only metastases. Her scans improved and Signatera became negative, but she still had many liver lesions and was not considered resectable. As of September 2025, she remained on chemotherapy while pursuing living-donor liver transplant evaluation.

The Patient StoryRead more →

Stage 4 colorectal cancer: complete response with panitumumab and FOLFOX4

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF wild type; MSS/pMMR; HER2 not overexpressed. CEA and CA19-9 were elevated.

Metastatic Site: periaortic and pelvic lymph nodes; left ovary/adnexa

As of November 2024, she was alive and continuing second-line FOLFIRI with stable disease after prior complete remission on panitumumab plus FOLFOX4 and later progression with ovarian metastasis.

PubMed CentralRead more →

Metastatic Colorectal Cancer With Severe Hypocalcemia After Denosumab

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: MLH1, PMS2, MSH2 and MSH6 retained; DPYD wild type

Metastatic Site: bone, liver

Bone imaging in November 2023 showed progression with more extensive skeletal involvement while he remained under care for metastatic colorectal cancer.

PubMed CentralRead more →

Stage IV Colorectal Cancer: Steve's Survivor Story

Patient Info: Steve Slack, Male, 40s | Stage IV

Metastatic Site: liver

As of June 2024, about 6 months after living-donor liver transplant, Steve had a clear surveillance scan and described himself as NED/no evidence of disease.

The Patient StoryRead more →

My Stage 4 Colorectal Cancer Story: How I Never Lost Hope

Patient Info: Jason Randall, Male | Stage IV

Metastatic Site: Liver; lungs; bone/sacrum

As of June 2023, Jason had a negative Signatera test, CT scans showing 9 months with no evidence of disease, and about 2.5 years off chemotherapy after Stage IV colorectal cancer treatment and lung ablation.

The Patient StoryRead more →

Stage IV Colorectal Adenocarcinoma: Amanda's Patient Story

Patient Info: Amanda, Under 40 | Stage IV

She remains on ongoing treatment for Stage IV disease and describes the cancer as pretty stable while maintaining a good quality of life.

Our Cancer StoriesRead more →

Severe lung injury during panitumumab treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: lungs, bones, pelvis

She died from respiratory failure 13 days after the onset of pulmonary symptoms. Autopsy showed diffuse alveolar damage consistent with acute respiratory distress syndrome and metastatic colon adenocarcinoma in the right lung.

PubMed CentralRead more →

Metastatic Colorectal Cancer Treatment Complicated by Severe Lung Inflammation

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: KRAS wild type; NRAS wild type

Metastatic Site: liver

He recovered from the severe treatment-related lung inflammation, was weaned off oxygen within 1 month, and continued oncology follow-up while living with Stage IV colorectal cancer.

PubMed CentralRead more →

Metastatic Colon Cancer With Tumor Thrombus Extending Into the Right Atrium

Patient Info: Anonymized, female, 40s

Biomarkers: BRAF wild-type, KRAS wild-type, NRAS wild-type

Her metastatic colorectal cancer progressed despite multiple treatment lines. Supportive care alone was chosen after her performance status deteriorated, and she later died from multiorgan failure in the setting of metastatic cancer.

PubMed CentralRead more →

Stage III low rectal cancer: complete response to mFOLFOX6 plus panitumumab and sphincter-preserving surgery

Patient Info: Anonymized, Male, 50s

Biomarkers: KRAS wild-type

As of March 2014, he was alive without evidence of recurrence 3 months after surgery, after complete pathologic response to neoadjuvant mFOLFOX6 plus panitumumab followed by intersphincteric resection and adjuvant UFT/leucovorin.

PubMed CentralRead more →