Sydney Stoner: Stage IIIB to Stage IV colon cancer with liver and lung involvement

Patient Info: Sydney Stoner, Female, Under 40 | Stage IV

Metastatic Site: Liver; lungs

Progressed from Stage IIIB colon cancer to Stage IV disease involving the liver and lungs; treated with surgery/ileostomy/reversal, FOLFOX/FOLFIRI, lung radiation, liver ablation/resection, capecitabine, and ongoing Lonsurf + Avastin.

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Progressive metastatic rectal cancer with bone and brain metastases during palliative pain care

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: bone, brain

By May 2025 the cancer had progressed to bone and brain despite multiple systemic regimens, and anticancer therapy was stopped as care shifted to palliative pain management.

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Stage IV Colorectal Adenocarcinoma: Adrienne's Patient Story

Patient Info: Adrienne, Female | Stage IV

Metastatic Site: Liver

As of June 2026, Adrienne had Stage IV colon adenocarcinoma with liver metastases, had experienced liver recurrence after intensive multimodal treatment, and was back on FOLFIRI plus Avastin.

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Stage III Colorectal Cancer: Shelley's Survivor Story

Patient Info: Shelley, Female, 40s | Stage III

Shelley completed colectomy and adjuvant chemotherapy for Stage IIIB colon cancer and was in survivorship/recovery with lingering treatment effects and follow-up needs; explicit NED status is not stated.

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Stage IV Colorectal Cancer: Lee's Patient Story

Patient Info: Lee, Male, 50s | Stage IV

Metastatic Site: Liver

Lee initially reached no evidence of disease after chemotherapy and right hemicolectomy, but the cancer recurred in the liver about 1 year later, requiring FOLFIRI and liver resection with major postoperative complications.

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Rectal cancer that spread through the lungs: complete remission after BRAF-targeted therapy

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: BRAF mutation; HER2-negative; microsatellite stable; no detectable KRAS or NRAS mutations

Metastatic Site: lungs (pulmonary lymphangitic carcinomatosis);…

After progression with recurrent lung metastases and a new pericardial effusion, she chose hospice care and died in February 2025, 19 months after diagnosis.

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Stage IV Colorectal Cancer: Lawrence's Survivor Story

Patient Info: Lawrence Henry, Male, 50s | Stage IV

Metastatic Site: Lung; abdominal lymph nodes

As of May 2026, Lawrence had no evidence of disease on scans since November, no blood-test signs of recurrence, was off colon cancer treatment, and returned to UT MD Anderson every 3 months for checkups.

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Stage IV Colorectal Cancer: Helen's Survivor Story

Patient Info: Helen, Female, 40s | Stage IV

Metastatic Site: Liver; pelvis

No active tumors / no evidence of disease after liver-directed treatment, liver surgery/ablation, colon resection, and hysterectomy, though she personally described herself as living with cancer and still planned cleanup treatment.

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Stage IV Colorectal Cancer: Joe's Patient Story

Patient Info: Joe, Male | Stage IV

Biomarkers: Specific biomarkers not reported

Metastatic Site: Liver; lymph nodes; lungs

Stage IV colon cancer initially reached no evidence of disease after FOLFOX plus panitumumab, but later recurred in the liver and lymph nodes, progressed to the lungs, and did not respond to later FOLFOX rechallenge or FOLFIRI before he started an immunotherapy clinical trial.

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Stage IV Colorectal Cancer: Alyssa's Patient Story

Patient Info: Alyssa Kelly, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

More than 4 years after pregnancy-associated Stage IV colorectal cancer, Alyssa was alive with her son, but after more than 1 year off chemotherapy she had several lung tumors, restarted chemotherapy, and was looking into clinical trials.

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Stage IV Colorectal Cancer: Sydney's Patient Story

Patient Info: Sydney, Female | Stage IV

Metastatic Site: Liver; lungs

Sydney was living with Stage IV colorectal cancer involving the liver and lungs. After multiple lines of treatment, she had a new liver spot and was back on lower-dose FOLFIRI every other Tuesday with a 46-hour pump.

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Stage IV sigmoid colon cancer: recurrence after FOLFOX, hepatectomy, and colectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Mismatch repair proficient; microsatellite stable; KRAS wild-type; BRAF wild-type; CEA 3.8 ng/mL at diagnosis

Metastatic Site: liver, lung

As of September 2025, metastatic sigmoid colon cancer had recurred in the lungs and remnant liver after initial FOLFOX, hepatectomy, and colectomy, requiring FOLFIRI plus cetuximab.

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Stage 4 colorectal cancer: complete response with panitumumab and FOLFOX4

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF wild type; MSS/pMMR; HER2 not overexpressed. CEA and CA19-9 were elevated.

Metastatic Site: periaortic and pelvic lymph nodes; left ovary/adnexa

As of November 2024, she was alive and continuing second-line FOLFIRI with stable disease after prior complete remission on panitumumab plus FOLFOX4 and later progression with ovarian metastasis.

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Metastatic colon cancer: soft-tissue and adrenal metastases responding to FOLFIRI plus bevacizumab

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type. CK20 and Ki-67 supported colorectal metastasis; CEA/CA19-9 were elevated.

Metastatic Site: lungs; left arm/biceps soft tissue; right…

As of May 2025, metastatic colon cancer involving soft tissue, muscle, lung history, and right adrenal gland had regressed after 12 months of FOLFIRI plus bevacizumab, and the patient was alive 1 year after chemotherapy completion.

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Stage IV HER2-Positive Colorectal Cancer: Emily's Patient Story

Patient Info: Emily King, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: lungs

Emily remained on active treatment for metastatic HER2-positive colon cancer, and her current Boston treatment had shrunk the cancer by 20% with fewer side effects.

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Stage IV cecum cancer with liver and ovarian metastases: ramucirumab-related nephrotic syndrome and glomerular microangiopathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Cancer biomarkers were not reported. Kidney injury workup showed severe protein leakage and biopsy-proven glomerular microangiopathy.

Metastatic Site: liver, right ovary

The liver metastasis shrank after XELOX plus bevacizumab and metastatic liver/ovarian sites were resected, but ramucirumab-based second-line therapy was stopped after nephrotic syndrome and severe glomerular microangiopathy; blood pressure and proteinuria improved with telmisartan.

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Stage IV Colorectal Cancer: Steve's Survivor Story

Patient Info: Steve Slack, Male, 40s | Stage IV

Metastatic Site: liver

As of June 2024, about 6 months after living-donor liver transplant, Steve had a clear surveillance scan and described himself as NED/no evidence of disease.

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Stage IV Colorectal Cancer: Jessica's Survivor Story

Patient Info: Jessica Dazzler, Female, Under 40 | Stage IV

Biomarkers: FoundationOne testing performed; exact mutation not stated

Metastatic Site: lungs, spine, rib

As of May 2024, Jessica said it took 3 years and 4 months to reach no evidence of disease after Stage IV colorectal cancer, though she remained anxious about future scans and possible circulating cancer.

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Regorafenib produced a radiologic complete response in metastatic colon cancer with lung metastases

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type; MSI-low

Metastatic Site: liver, lung

Nine months after stopping regorafenib, CT showed scarring of the lung metastases consistent with a radiologic complete response.

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Stage IV Colorectal Cancer: Jeff's Patient Story

Patient Info: Jeff Williams, Male, 50s | Stage IV

Metastatic Site: Liver; lungs

As of December 2023, Jeff was living with recurrent Stage IV colorectal cancer, had recently developed more lung tumors, continued chemotherapy locally every 2 weeks, and returned to UT MD Anderson every 3 months for scans.

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Stage IV Colorectal Cancer: Michelle's Patient Story

Patient Info: Michelle Cappel, Female, 40s | Stage IV

Metastatic Site: Leg/femoral nerve area

As of July 2023, Michelle was living with recurrent Stage IV colorectal cancer after prior NED, leg/femoral-nerve recurrence, radiation, surgery with clear margins, and ongoing surveillance.

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My Stage 4 Colorectal Cancer Story: How I Never Lost Hope

Patient Info: Jason Randall, Male | Stage IV

Metastatic Site: Liver; lungs; bone/sacrum

As of June 2023, Jason had a negative Signatera test, CT scans showing 9 months with no evidence of disease, and about 2.5 years off chemotherapy after Stage IV colorectal cancer treatment and lung ablation.

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Continuing 5-FU After Severe Chest Pain During Metastatic Colon Cancer Treatment

Patient Info: Anonymized, Female | Stage IV

Pretreatment with diltiazem allowed her to complete a 48-hour 5-FU infusion without recurrent chest pain, abnormal heart rhythm or loss of heart function.

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32-year-old woman with Stage IV rectal cancer, liver and lung metastases, targeted chemotherapy, surgery, ablation, radiation, and ongoing chemotherapy

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: KRAS wild-type; NRAS wild-type; BRAF wild-type

Metastatic Site: Liver | Lung | Presacral/perirectal lymph nodes

As of the story endpoint around December 2020, she was 5 years into treatment for Stage IV rectal cancer after multiple systemic regimens, bowel/liver/lung surgery, liver recurrence treatment, ablation, lung surgery, TOMO radiation, and ongoing chemotherapy.