Metastatic Breast Cancer With Brain, Bone, Lung and Liver Disease Responding During Eribulin Treatment

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 negative, Ki67 10%. Lung metastasis: ER 90%

Metastatic Site: lung, bone, brain, liver

Eribulin remained ongoing with reduced brain lesions, stable bone disease and continued shrinkage of liver metastases after prior systemic progression.

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Stage IV Ovarian Cancer With 20 Years of Tumor-Free Survival

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: BRCA1 negative, BRCA2 negative

Metastatic Site: peritoneum, liver, right adrenal gland

Regular follow-up found no recurrence or other tumor, and at 20 years of follow-up she remained tumor-free with good health and quality of life.

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Metastatic Breast Cancer With Liver Progression Treated Through Multiple Chemotherapy Lines

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 3+, Ki67 15%. Liver metastasis: ER 30%

Metastatic Site: pleura, liver

After several periods of response and later liver progression, she remained on active treatment with pegylated liposomal doxorubicin.

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Metastatic Lobular Breast Cancer With Long-Term Disease Control Across Multiple Therapies

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER negative, HER2 negative, Ki67 17%. 2006 recurrence: ER 40%

Metastatic Site: pleura, liver, skin, bone

She was alive on ongoing metronomic vinorelbine with substantial disease stabilization at the most recent follow-up.

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Bilateral Breast Cancers Followed by Metastatic Disease and Long Eribulin Treatment

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Left primary: ER 90%, HER2 FISH not amplified, Ki67 25%. Right primary: ER 90%

Metastatic Site: lung, pleura, liver, bone

After pelvic bone metastases appeared in 2017, she stopped eribulin, received pelvic radiation and remained on fulvestrant treatment.

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Recurrent Breast Cancer With Liver Metastases Treated Through Multiple Chemotherapy Lines

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: Initial tumor: ER positive, HER2 0. Liver metastasis: ER 100%

Metastatic Site: liver

After liver progression following 18 cycles of eribulin, she started weekly carboplatin and remained in active treatment.

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Metastatic Breast Cancer Responding to Eribulin After Repeated Liver Progression

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: ER 100%, HER2 negative

Metastatic Site: bone, liver

Eribulin remained ongoing with repeated partial responses documented through 12 cycles and no need for dose reduction.

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Stage II BRCA1 Ovarian Cancer: Barb's Patient Story

Patient Info: Barb White, female, 50s | Stage II

Biomarkers: BRCA1 mutation

Barb completed chemotherapy in June 2014 and later described being able to move forward after treatment.

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Stage III Ovarian Cancer: Dianne's Patient Story

Patient Info: Dianne Simpson, female, 70+ | Stage III

Dianne completed treatment in April 2017 after chemotherapy, hysterectomy and a pembrolizumab clinical trial and was looking ahead to survivorship.

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Breast Cancer: Kat's Patient Story

Patient Info: Kat

Nine months after diagnosis, she had completed radiation treatment and was looking ahead to recovery and hair regrowth.

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Stage II Ovarian Cancer: Betsy's Patient Story

Patient Info: Betsy Feldmann, 50s | Stage II

After treatment ended, Betsy returned to endurance events, including triathlon competition, long-distance cycling, and open-water swimming.

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Stage IV ERBB2-Mutated Lung Cancer With Extensive Bone Metastases

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ERBB2 exon 20 insertion. A PIK3CA mutation was later detected at progression and considered a possible resistance mechanism.

Metastatic Site: bone

After progression on pemetrexed following several earlier treatment lines, she transitioned to hospice care.

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ERBB2-Mutated Metastatic Lung Adenocarcinoma Progressing Through Multiple Therapies

Patient Info: Anonymized, female

Biomarkers: ERBB2 mutation

The cancer progressed during afatinib, nivolumab and a later paclitaxel rechallenge.

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ERBB2-Mutated Metastatic Lung Adenocarcinoma With Limited Disease Control Across Multiple Therapies

Patient Info: Anonymized, female

Biomarkers: ERBB2 V776delinsVC mutation

After temporary stable disease when bevacizumab was added to chemotherapy, the cancer progressed on trastuzumab plus paclitaxel and then erlotinib.

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Stage III Ovarian Cancer: Pam's Survivor Story

Patient Info: Pam Scarpino, female | Stage III

Pam had no evidence of disease in March 2010 after treatment for recurrence and remained in remission at the time of the story.

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Metastatic signet-ring gastric cancer spreads diffusely to the thyroid and skin

Patient Info: Anonymized, Female, 70+ | Stage IV

Metastatic Site: thyroid, skin

She died 1 month after hospitalization after her condition worsened despite supportive care.

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Lung Cancer Immunotherapy Caused New Type 1 Diabetes

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: No ALK, ROS1, KRAS or EGFR alteration was detected; CK7-positive; TTF-1-negative; PAX-negative; CK20-negative

Metastatic Site: Pleura

After 4 combination-treatment cycles, the right-lung nodules had decreased markedly and nearly resolved. He continued maintenance pembrolizumab every 3 weeks and remained on insulin with stable glucose control.

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Lung Adenocarcinoma Metastatic to the Breast With Inflammatory Breast-Like Symptoms

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: EGFR positive. Breast metastasis: TTF-1 positive

Metastatic Site: right breast

A PET scan after breast radiation showed no metabolically active cancer, but she died 2 months after the breast metastasis was diagnosed.

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Ovarian Adenosquamous Cancer Treated With Surgery and Chemotherapy

Patient Info: Anonymized, female, 50s | Stage I

Five and a half years after chemotherapy, she remained free of recurrence.

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Ovarian Cancer With Severe Dermatomyositis During Treatment

Patient Info: Anonymized, female, 60s | Stage III

Biomarkers: BRCA1 mutation

She continued paclitaxel and carboplatin while being treated for severe dermatomyositis and later described herself as finally on the mend.

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Stage I Ovarian Squamous Cell Cancer Found in a Long-Standing Dermoid Cyst

Patient Info: Anonymized, female, 40s | Stage I

At 22 months after treatment, she had no clinically identifiable recurrence.

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Stage IV gastric cancer with peritoneal metastases controlled for years with intraperitoneal chemotherapy

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: peritoneum, bone

She had survived 5 years 2 months after diagnosis of peritoneal carcinomatosis, despite later suspected ovarian metastases, confirmed bone metastases and recurrent peritoneal disease.

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Metastatic Ovarian Cancer Discovered After Recurrent Embolic Strokes

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: left axillary lymph node

She received 1 cycle of paclitaxel and carboplatin and died on day 54 of her second hospital admission. Her family declined an autopsy.

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Stage IV gastric adenocarcinoma causes inferior vena cava compression and severe leg swelling

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: omentum

At the latest follow-up, she was receiving cycle 5 of paclitaxel and trastuzumab. Her appetite, energy and leg edema had improved, although abdominal bloating persisted.

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