Severe gastrointestinal bleeding and perforation during apatinib treatment for metastatic gastric cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 IHC 2+; FISH negative for HER2 amplification

Metastatic Site: peritoneum, ileum

She died on February 23, 2015 after gastrointestinal perforation, septic shock and multiple organ dysfunction during progressive metastatic disease.

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High-Grade Serous Ovarian Cancer With a Paraneoplastic Skin Condition

Patient Info: Anonymized, female, 60s

During first-line carboplatin and paclitaxel chemotherapy, the paraneoplastic skin changes regressed and the CA125 level returned to the normal range.

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High-Grade Serous Ovarian Cancer With Markedly Elevated Amylase

Patient Info: Anonymized, female | Stage III

At 6 months, she was receiving 3 additional chemotherapy cycles after an excellent initial clinical and imaging response, with later marker changes reflecting periods of progression and response.

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Stage III Ovarian Cancer Treated Over Years Before a Separate Oral Cancer

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

After prolonged treatment for recurrent ovarian cancer, follow-up visits documented her as free from ovarian disease.

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Ovarian Cancer Recurrence Complicated by a Benign Surgical Stitch Reaction

Patient Info: Anonymized, female, 40s | Stage III

Diffuse peritoneal relapse was confirmed, and she remained on third-line chemotherapy with persistent evidence of ovarian cancer.

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Ovarian Cancer Recurs as a Solitary Splenic Metastasis Six Years Later

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: spleen

After removal of the solitary splenic metastasis, she returned to gynecologic oncology and received another course of paclitaxel and carboplatin.

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Fertility-Sparing Surgery for Stage I Endometrioid Ovarian Cancer

Patient Info: Anonymized, female, Under 40 | Stage I

Biomarkers: BRCA1/2 negative

She had two spontaneous pregnancies after treatment and remained without evidence of disease at 46 months.

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Stage III BRCA1 Ovarian Cancer: Meredith's Survivor Story

Patient Info: Meredith Ippolito, female | Stage III

Biomarkers: BRCA1 mutation

Meredith was told she was cancer-free in April 2009 and continued follow-up visits every 6 months.

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Recurrent Ovarian Cancer With Tumor Lysis Syndrome After Chemotherapy

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: lungs

After 9 years of stable disease, the ovarian cancer progressed extensively and the first cycle of renewed chemotherapy was complicated by severe tumor lysis syndrome and multiorgan illness.

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Stage III Ovarian Cancer Diagnosed With a Separate Vaginal Cancer

Patient Info: Anonymized, 50s | Stage III

A whole-body PET scan 4 weeks after treatment found no active malignant disease, and she continued regular follow-up.

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ER/PR-positive breast cancer with bilateral ovarian metastases controlled after oophorectomy and aromatase inhibitor

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; CK7-positive; gross cystic disease fluid protein-15-positive; CK20-negative

Metastatic Site: bilateral ovaries

After bilateral oophorectomies and aromatase inhibitor therapy, pleural effusion resolved, CEA and CA 15-3 decreased below the normal upper limit, and she remained well with no further recurrence for 40 months.

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Hormone-positive breast cancer with axillary recurrence responding to hyperthermia, radiation, and chemotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: ER-positive; PR-positive; HER2-negative

The left axillary recurrence enlarged during weekly paclitaxel and radiotherapy, then became nearly flat and was assessed as a complete response 8 weeks after adding hyperthermia.

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Stage IV EBV-positive lymphoepithelioma-like lung cancer with brain metastasis

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EBV-positive by in-situ hybridization

Metastatic Site: brain, retroperitoneal/posterior mediastinal soft…

Remained well and disease-free 6 months after resection of the retroperitoneal/posterior mediastinal metastasis and 8 years after initial presentation.

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Stage IV lung squamous cell carcinoma with liver metastasis treated with chemotherapy and 90Y radioembolization

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: liver

After treatment for liver metastasis, PET CT 2 months after 90Y radioembolization showed complete tumor response without residual tumor, and she was alive without active disease.

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Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Long-Term Maintenance Therapy

Patient Info: Anonymized, 50s | Stage III

Biomarkers: BRCA1 mutation

After long-term maintenance therapy, she had no evidence of ovarian cancer at the latest follow-up.

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Recurrent Stage III Ovarian Cancer in a BRCA2 Carrier Treated Over Many Years

Patient Info: Anonymized, 40s | Stage III

Biomarkers: BRCA2 mutation

She later developed a separate aggressive oral squamous cell carcinoma and died in 2011 from acute airway obstruction during progression of that cancer.

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Stage III Ovarian Cancer in a BRCA1 Carrier With Long-Term Disease Control

Patient Info: Anonymized, 60s | Stage III

Biomarkers: BRCA1 mutation

At the latest follow-up in January 2012, she had no recurrence of ovarian cancer and was well.

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Recurrent Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Multiple Therapies

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

By late 2011, hilar nodal disease was slowly progressing and bevacizumab was started for the recurrent ovarian cancer.

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Recurrent Stage III Ovarian Cancer Complicated by Severe Kidney Injury

Patient Info: Anonymized, female, 70+ | Stage III

After further intra-abdominal cancer progression and severe kidney injury, she developed seizures, encephalopathy, and limb ischemia and died 1 week after hospitalization in May 2011.

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Recurrent Ovarian Cancer With Treatment-Related Kidney Failure and Dialysis

Patient Info: Anonymized, female, Under 40

The ovarian cancer later progressed with enlarging pelvic masses, rectal obstruction, and intestinal perforation, and she died in February 2011.

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Recurrent Ovarian Cancer With Severe Kidney Injury During Long-Term Treatment

Patient Info: Anonymized, female, 60s

Despite severe chronic kidney disease, later chemotherapy produced some regression of the progressing ovarian cancer with each sequential regimen.

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Stage IV large-cell lung cancer with adrenal metastasis: no recurrence after R0 surgery

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Marker profile supported large-cell lung carcinoma: CK7/CEA/Ber-EP4 positive, with neuroendocrine and prostate markers negative.

Metastatic Site: left adrenal gland

Six months after combined lung and adrenal surgery with R0 resection, he had no evidence of recurrence.

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Stage IV lung adenocarcinoma with brain metastasis: partial remission after pemetrexed/cisplatin and AOSD-like paraneoplastic syndrome

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: No tumor molecular biomarkers reported. AOSD-like syndrome had high ferritin, inflammation markers, and RF/ANA negative.

Metastatic Site: brain

As of November 2011, pemetrexed/cisplatin produced partial remission of Stage IV lung adenocarcinoma and controlled the AOSD-like paraneoplastic syndrome without recurrent fever, rash, or arthralgia.

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Recurrent HER2-amplified breast cancer: complete remission on trastuzumab-based therapy

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Primary tumor was ER/PR negative and HER2 not amplified. Recurrent lymph-node disease became ER/PR positive and HER2 amplified by FISH.

Metastatic Site: left axillary and infraclavicular lymph nodes

After HER2-amplified nodal recurrence, paclitaxel plus trastuzumab produced complete clinical remission; she continued trastuzumab monotherapy with tolerable neuropathy.

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