What happened, in summary

A 50-year-old premenopausal woman was diagnosed with Stage IV epithelial ovarian cancer involving the peritoneum, liver and right adrenal gland. Pathology showed high-grade serous carcinoma, and molecular testing was negative for BRCA1 and BRCA2 mutations. She underwent extensive surgery that included removal of both ovaries and adnexa, hysterectomy, omentectomy, resection of cancerous nodes, removal of liver metastases and resection of the right adrenal gland. She then received 6 cycles of carboplatin and cyclophosphamide. After chemotherapy, CT showed suspicious lymph nodes near the pancreas and spleen. During second-look surgery, mesenteric lymph nodes were removed and confirmed to contain metastatic ovarian cancer. Treatment was changed to high-dose carboplatin and paclitaxel, followed by autologous hematopoietic stem cell transplantation. She also received subcutaneous Viscum album extract as an adjunctive treatment. From the surgery performed in month 8 onward, regular follow-up found no signs of recurrence or another tumor. At 20 years of follow-up, she remained tumor-free, was in good health and had a good quality of life.