Ovarian Clear Cell Cancer Surgery Followed by a Serious Bowel Complication

Patient Info: Anonymized, Female

She recovered from the bowel perforation and reactive subdiaphragmatic cyst, stopped infection medication after negative cultures, and was discharged 78 days after the initial surgery while additional anticancer treatment remained planned.

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BRCA1-Mutated Ovarian Cancer Responding to Niraparib After Olaparib Progression

Patient Info: Anonymized, Female, 60s

Biomarkers: Germline BRCA1 pathogenic variant c.188T>A; CA-125 4

Two months after starting niraparib, imaging showed a partial response and CA-125 normalized. At 15 months, she had achieved a complete response and remained progression-free while niraparib continued.

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Ovarian Cancer: Chen's Survivor Story

Patient Info: Chen Wen Ye, Under 40

Nearly 5 years after diagnosis, Chen was cancer-free and attending regular follow-up while volunteering to support other young patients.

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Ovarian cancer chemotherapy continued after paclitaxel-related liver injury

Patient Info: Anonymized, Female, 50s | Stage II

Biomarkers: somatic BRCA1/2 negative

She completed all 6 planned chemotherapy cycles after dose reduction for liver toxicity and then entered routine surveillance.

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Metastatic Ovarian Cancer Presenting With Painful Finger Ischemia

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Biomarkers: CA-125: 90.6 kU/L after 4 cycles of chemotherapy

Metastatic Site: peritoneum|omentum

She continued chemotherapy and palliative symptom management after debulking surgery. She died from an intracranial hemorrhage 10 months after her original presentation.

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Stage I Ovarian Mesonephric-Like Adenocarcinoma With Mixed Müllerian Features

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: KRAS p.; ARHGAP35 p.L1295Cfs*20; PPP2R1A p.; IRS1 p. in endometrioid and mesonephric-like areas; chromosome 1q gain

A 63-year-old woman underwent surgery for a 12 cm stage I ovarian mesonephric-like adenocarcinoma containing mixed mucinous and endometrioid components with shared molecular alterations.

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Stage IV Ovarian Cancer: Melbey's Patient Story

Patient Info: Melbey Segovia, Female | Stage IV

Melbey Segovia died on May 4, 2021, about 5 years and 3 months after her February 2016 diagnosis, after three relapses and hospice care.

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Stage III Ovarian Cancer: Jaclyn's Patient Story

Patient Info: Jaclyn (Jackie) VanRaaphorst | Stage III

Biomarkers: FRα-positive; CA-125 monitored

AACR later reported that Jackie died on January 16, 2025.

Ovarian Cancer: Jennifer's Patient Story

Patient Info: Jennifer Thorn, Female, 40s

Living with ovarian cancer and continuing gemcitabine after about 2 years of treatment.

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Stage I BRCA1 Ovarian Cancer: Carol's Survivor Story

Patient Info: Carol Arnhart | Stage I

Biomarkers: BRCA1 mutation

After staging surgery and 6 rounds of carboplatin and paclitaxel, she reported no evidence of ovarian cancer.

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Stage I Ovarian Cancer: Elle's Patient Story

Patient Info: Elle Simone Scott, Female, Under 40 | Stage I

Living with recurrent ovarian cancer for more than 6 years after her September 2016 diagnosis, with an active clinical trial slowing progression at the May 2023 publication.

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Stage IV Ovarian Cancer Complicated by Anti-Yo Cerebellar Degeneration

Patient Info: Anonymized, Female | Stage IV

Biomarkers: CA-125: 1767 kU/L; anti-Yo antibodies positive in serum and cerebrospinal fluid

Her anti-Yo paraneoplastic cerebellar degeneration progressed despite methylprednisolone and plasma exchange. Care became palliative, and she died 2 months after hospital admission.

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Stage III Ovarian Cancer: Karoline's Patient Story

Patient Info: Karoline Strauss, female | Stage III

After resuming etigilimab and nivolumab, the patient felt markedly better; by the eighth infusion, some tumors had disappeared and others were shrinking, and treatment was continuing.

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Stage IIIC Ovarian Cancer Found During Preoperative Screening

Patient Info: Anonymized, Female | Stage III

Biomarkers: BRCA1 pathogenic variant on homologous recombination deficiency testing; germline BRCA1 pathogenic variant

At approximately 1 year after surgery, she was alive without evidence of recurrence while continuing olaparib and bevacizumab maintenance therapy.

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Growing Masses After Chemotherapy for an Ovarian Germ Cell Tumor

Patient Info: Anonymized, Female, Under 40

Biomarkers: AFP 581.2 ng/mL and CA-125 74.3 U/mL after surgery

Despite 6 chemotherapy cycles and normalization of AFP, abdominal and pelvic masses continued to grow while CA-125 and CEA increased. She sought a second opinion and underwent imaging and biopsy of an abdominal mass.

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Recurrent Malignant Ovarian Steroid Cell Tumor Treated With Multiple Therapies

Patient Info: Anonymized, Female

Biomarkers: PIK3CA, and ATM mutations; ER negative; PR negative

She experienced repeated pelvic and lung recurrences. Platinum-based treatment produced a complete PET-CT response and olaparib maintenance provided about 1 year without progression before a 5 mm lung recurrence was surgically removed.

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Stage III Ovarian Cancer During Care for Common Variable Immunodeficiency

Patient Info: Anonymized, Female | Stage III

She remained alive on maintenance bevacizumab, with no radiologic evidence of ovarian-cancer progression.

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Malignant Struma Ovarii Managed With Surgery and Long-Term Surveillance

Patient Info: Anonymized, Female

Biomarkers: BRAF mutation negative

She remained asymptomatic with thyroid-stimulating hormone at the treatment goal and entered long-term thyroglobulin surveillance.

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Stage IIIC Primary Ovarian Leiomyosarcoma Treated With Debulking Surgery and Chemotherapy

Patient Info: Anonymized, Female | Stage III

Biomarkers: SMA positive; caldesmon positive; Ki-67 15%–20%; p53 negative

She recovered from extensive cytoreductive surgery, reported resolution of her symptoms, and began planned adjuvant Adriamycin and ifosfamide.

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Stage III BRCA Ovarian Cancer: Mimi's Survivor Story

Patient Info: Mimi Gallagher, 40s | Stage III

Biomarkers: BRCA-positive

Mimi was cancer-free after surgery and 4 months of intraperitoneal chemotherapy, completed in December 2012.

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Ovarian Cancer Can Present Unique Challenges Around Gender

Patient Info: Anonymized, 40s

At annual follow-up, the ovarian cancer remained in remission with no recurrences since treatment ended in December 2009.

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Stage III Ovarian Cancer: Margaret's Patient Story

Patient Info: Margaret Winchester | Stage III

Margaret experienced recurrent small ovarian tumors, underwent cryoablation, and had recently completed another clinical trial while continuing her work.

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Stage IV Ovarian Cancer: Carolyn's Patient Story

Patient Info: Carolyn Ridge, Under 40 | Stage IV

Carolyn was dealing with an ovarian cancer recurrence diagnosed in September 2014.

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Ovarian Cancer: Faye's Patient Story

Patient Info: Faye Belvin, Female

Faye was still receiving the trial combination and said the treatment was working and that she felt better than she had in the previous 2 years.