Hormone Therapy for Ovarian Cancer: 14 Real Stories

Targeted treatment for an 89-year-old woman with Stage IV HRD-positive ovarian cancer

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: HRD-positive; germline BRCA2 pathogenic variant

Follow-up imaging showed a partial response, tumor markers improved, and she remained on treatment with better appetite and general condition at 7 months.

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Stage III Ovarian Cancer: Mary's Survivor Story

Patient Info: Mary Catherine Riley, Female, 40s | Stage III

After a 2023 recurrence, Mary achieved a complete response within 1 year on avutometinib and defactinib. She continues the approved combination with quarterly CT scans and monthly labs and has no evidence of disease.

Ovarian Cancer: Lissa's Survivor Story

Patient Info: Lissa Fancher

At the latest update, the patient had no evidence of disease, tumor markers had dropped significantly, and daily hormone therapy was being used to reduce recurrence risk.

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Recurrent Malignant Ovarian Steroid Cell Tumor Treated With Multiple Therapies

Patient Info: Anonymized, Female

Biomarkers: PIK3CA, and ATM mutations; ER negative; PR negative

She experienced repeated pelvic and lung recurrences. Platinum-based treatment produced a complete PET-CT response and olaparib maintenance provided about 1 year without progression before a 5 mm lung recurrence was surgically removed.

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Malignant Struma Ovarii Managed With Surgery and Long-Term Surveillance

Patient Info: Anonymized, Female

Biomarkers: BRAF mutation negative

She remained asymptomatic with thyroid-stimulating hormone at the treatment goal and entered long-term thyroglobulin surveillance.

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Metastatic Follicular Carcinoma Arising From Struma Ovarii

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: right fallopian tube|peritoneum|omentum|bladder…

Four years after diagnosis, she had no evidence of recurrence or metastasis while continuing thyroid-hormone suppression and 6-monthly surveillance.

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Ovarian Granulosa Cell Tumor Recurring 17 Years After Surgery

Patient Info: Anonymized, Female, 70+

Biomarkers: Weak oestrogen sensitivity

Complete resection was not possible, but debulking relieved pressure on surrounding structures and improved her quality of life. She then continued oncology care with palliative carboplatin and paclitaxel.

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Ovarian Cancer: Dana's Patient Story

Patient Info: Dana Kivel, female

Dana was living with recurrent, metastatic granulosa cell ovarian cancer and taking an aromatase inhibitor for a current tumor.

MSI-High Malignant Struma Ovarii With Lung and Liver Metastases 17 Years Later

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: NRAS, and ATM mutations; Ki-67 approximately 15%–29%

Metastatic Site: lungs|liver

She remained asymptomatic and tolerated pembrolizumab without obvious adverse effects after 4 doses, with follow-up imaging planned for metastatic lung and liver disease.

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Ovarian cancer that later spread to an axillary lymph node

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: axillary lymph nodes

After later peritoneal progression, additional treatment brought the disease to a stable state through her last recorded visit in July 2019.

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Metastatic Low-Grade Serous Ovarian Cancer Causing Severe Pulmonary Hypertension

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: pleura, pulmonary arteries

She died on hospital day 29 after rapidly progressive pulmonary hypertension. Autopsy attributed the pulmonary hypertension to metastatic ovarian serous carcinoma with pulmonary arterial tumor emboli.

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Malignant Struma Ovarii With Papillary Thyroid-Type Cancer

Patient Info: Anonymized, female, 40s

Biomarkers: KRAS mutation

Radioactive iodine scans showed no local or distant disease, and she was well and symptom-free 12 months after the initial diagnosis while continuing follow-up.

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Stage IV Ovarian Cancer: Bre's Patient Story

Patient Info: Bre Tipps, female, Under 40 | Stage IV

A recent CT scan showed the remaining tumors calcifying and dying during hormonal therapy, although the patient expected to need ongoing ovarian cancer treatment.

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Papillary Thyroid-Type Cancer Arising in Struma Ovarii

Patient Info: Anonymized, female, 40s

Six months after surgery, imaging showed no recurrence or metastasis and thyroglobulin was undetectable, supporting remission.

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