Metastatic Ovarian Cancer: 11 Real Stories

Metastatic Ovarian Cancer Presenting With Painful Finger Ischemia

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Biomarkers: CA-125: 90.6 kU/L after 4 cycles of chemotherapy

Metastatic Site: peritoneum|omentum

She continued chemotherapy and palliative symptom management after debulking surgery. She died from an intracranial hemorrhage 10 months after her original presentation.

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Metastatic Follicular Carcinoma Arising From Struma Ovarii

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: right fallopian tube|peritoneum|omentum|bladder…

Four years after diagnosis, she had no evidence of recurrence or metastasis while continuing thyroid-hormone suppression and 6-monthly surveillance.

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Recurrent Ovarian Cancer and Olaparib-Related Skin Toxicity

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: peritoneum|liver

The latest chemotherapy was effective, and she was alive without signs of another recurrence at the last documented follow-up.

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Ovarian Cancer Metastasis to the Cervical Spinal Canal

Patient Info: Anonymized, Female, 70+ | Stage Metastatic/Advanced

Metastatic Site: brain|cervical intradural extramedullary space

Her neck and shoulder pain resolved after spinal surgery, but she developed recurrent brain disease and died from cachexia 4 months after the spinal operation.

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Metastatic Clear Cell Ovarian Cancer Complicated by Treatment-Related Sarcoidosis

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Metastatic Site: peritoneum

During a treatment holiday, biopsy and laboratory evaluation showed treatment-related sarcoidosis rather than ovarian-cancer spread in the enlarged lymph nodes. After prednisone, the sarcoidosis resolved and imaging showed no progression of the clear cell ovarian cancer; she remained clinically well 4 months later.

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MSI-High Malignant Struma Ovarii With Lung and Liver Metastases 17 Years Later

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: NRAS, and ATM mutations; Ki-67 approximately 15%–29%

Metastatic Site: lungs|liver

She remained asymptomatic and tolerated pembrolizumab without obvious adverse effects after 4 doses, with follow-up imaging planned for metastatic lung and liver disease.

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Rapidly Progressive Stage IIIA2 Ovarian Cancer With Anaplastic Features

Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced

Biomarkers: CA-125 419 IU/mL; CA19-9 elevated; lactate dehydrogenase elevated

Metastatic Site: lungs|liver

Within 30 days of surgery, the cancer had progressed with a large retroperitoneal nodal mass and new lung and liver metastases. She died from advanced ovarian cancer 5 weeks after surgery.

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Aggressive Presumed Ovarian Solid Pseudopapillary Tumor With Widespread Metastases

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: peritoneum|pelvic soft tissue|inguinal lymph…

The disease progressed rapidly across multiple abdominal and nodal sites. She died from disease-related complications 2 months after the oncology consultation while receiving induction chemotherapy.

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Stable Brain Metastases During Niraparib Maintenance for Ovarian Cancer

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: CA-125 4019 kU/L; pathogenic germline BRCA1 mutation

Metastatic Site: brain

After 17 months of niraparib, her brain metastases remained stable. She had a performance status of 0 and reported a full, normal quality of life.

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Ovarian Cancer Relapse Causing Fluid Around the Heart

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: PAX8 positive; CK7 positive; WT1 positive; p53 positive; ER positive; PR negative; isolated PMS2 loss; MSH2 retained; MSH6 retained; MLH1 retained; two BRCA1 variants of uncertain significance

Metastatic Site: omentum|pericardium

She was alive after completing chemotherapy for the pericardial relapse and was receiving olaparib maintenance. The fluid around the heart did not recur immediately after the surgical window.

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Ovarian Cancer With Pleural Spread and Recurrent Dermatomyositis

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Metastatic Site: pleura

She had symptomatic improvement after 2 cycles of carboplatin and liposomal doxorubicin for recurrent disease.

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