Radiation for Ovarian Cancer: 15 Real Stories

Malignant Struma Ovarii With Abdominal and Liver Metastases Treated With Radioactive Iodine

Patient Info: Anonymized, female, 40s

Biomarkers: TTF-1 positive; thyroglobulin positive; Ki-67 approximately 1-5%; CA-125 1238.9 IU/mL at presentation

After approximately 5 years of follow-up, thyroglobulin remained steady and her condition was considered stable.

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Small Cell Ovarian Cancer Causing Acute Kidney Injury

Patient Info: Anonymized, Female | Stage III

Biomarkers: Somatic SMARCA4 alterations; no germline SMARCA4 pathogenic variant

Combined pembrolizumab, carboplatin, and paclitaxel was continued after marked radiologic improvement, with an excellent PET-CT response documented after 13 cycles.

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Ovarian Cancer Spreads to the Breast During Platinum-Resistant Recurrence

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: BRCA1/2-negative; HRD-positive; PD-L1-positive; folate receptor alpha-positive

Metastatic Site: right breast, right axillary lymph nodes, cervical…

She remained alive with stable disease about 2 years after the breast metastasis was diagnosed while receiving seventh-line mirvetuximab-soravtansine.

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Recurrent Malignant Ovarian Steroid Cell Tumor Treated With Multiple Therapies

Patient Info: Anonymized, Female

Biomarkers: PIK3CA, and ATM mutations; ER negative; PR negative

She experienced repeated pelvic and lung recurrences. Platinum-based treatment produced a complete PET-CT response and olaparib maintenance provided about 1 year without progression before a 5 mm lung recurrence was surgically removed.

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Metastatic Follicular Carcinoma Arising From Struma Ovarii

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: right fallopian tube|peritoneum|omentum|bladder…

Four years after diagnosis, she had no evidence of recurrence or metastasis while continuing thyroid-hormone suppression and 6-monthly surveillance.

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Ovarian Cancer Metastasis to the Cervical Spinal Canal

Patient Info: Anonymized, Female, 70+ | Stage Metastatic/Advanced

Metastatic Site: brain|cervical intradural extramedullary space

Her neck and shoulder pain resolved after spinal surgery, but she developed recurrent brain disease and died from cachexia 4 months after the spinal operation.

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Metastatic Clear Cell Ovarian Cancer Complicated by Treatment-Related Sarcoidosis

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Metastatic Site: peritoneum

During a treatment holiday, biopsy and laboratory evaluation showed treatment-related sarcoidosis rather than ovarian-cancer spread in the enlarged lymph nodes. After prednisone, the sarcoidosis resolved and imaging showed no progression of the clear cell ovarian cancer; she remained clinically well 4 months later.

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MSI-High Malignant Struma Ovarii With Lung and Liver Metastases 17 Years Later

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: NRAS, and ATM mutations; Ki-67 approximately 15%–29%

Metastatic Site: lungs|liver

She remained asymptomatic and tolerated pembrolizumab without obvious adverse effects after 4 doses, with follow-up imaging planned for metastatic lung and liver disease.

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Ovarian Wilms tumor with early abdominal recurrence

Patient Info: Anonymized, Female, Under 40

Biomarkers: WT1-positive; residual tumor MyoD1-positive

After 3 months of radiation and a further 3 months of chemotherapy, PET showed no FDG-avid malignancy.

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Stable Brain Metastases During Niraparib Maintenance for Ovarian Cancer

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: CA-125 4019 kU/L; pathogenic germline BRCA1 mutation

Metastatic Site: brain

After 17 months of niraparib, her brain metastases remained stable. She had a performance status of 0 and reported a full, normal quality of life.

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Stage III Ovarian Cancer: Pam's Survivor Story

Patient Info: Pam Scarpino, female | Stage III

Pam had no evidence of disease in March 2010 after treatment for recurrence and remained in remission at the time of the story.

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Malignant Struma Ovarii With Papillary Thyroid-Type Cancer

Patient Info: Anonymized, female, 40s

Biomarkers: KRAS mutation

Radioactive iodine scans showed no local or distant disease, and she was well and symptom-free 12 months after the initial diagnosis while continuing follow-up.

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Ovarian Granulosa Cell Tumor Spreads to the Spine and Kidney

Patient Info: Anonymized, female, 40s | Stage IV

Metastatic Site: spine, kidney

Years after the original ovarian tumor, metastatic granulosa cell tumor was confirmed in the L1 vertebra and later in the left kidney.

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Ovarian Cancer That Spread to the Cerebellum 10 Years Later

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: right cerebellum

After removal of the cerebellar metastasis, her headache and vertigo improved and she subsequently received whole-brain radiation.

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Papillary Thyroid-Type Cancer Arising in Struma Ovarii

Patient Info: Anonymized, female, 40s

Six months after surgery, imaging showed no recurrence or metastasis and thyroglobulin was undetectable, supporting remission.

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