Ovarian cancer chemotherapy continued after paclitaxel-related liver injury

This ovarian cancer diagnosis at a glance

Stage at diagnosis
Stage II
Biomarkers
somatic BRCA1/2 negative
Sex
Female
Treatment
surgery and chemotherapy
Outcome
Care Ongoing

Treatment course, step by step

  1. Underwent primary debulking surgery including hysterectomy, bilateral adnexectomy and omentectomy.
  2. Began carboplatin plus paclitaxel chemotherapy.
  3. After paclitaxel-related liver injury, treatment was delayed and paclitaxel was dose-reduced.
  4. Completed 6 chemotherapy cycles and entered routine surveillance.

What happened, in summary

A 53-year-old woman presented in July 2022 with large pelvic masses. Surgery included hysterectomy, removal of both ovaries and fallopian tubes, omentectomy, appendectomy and pelvic lymph-node sampling. Pathology showed high-grade serous carcinoma involving both ovaries, with no cancer found in the sampled pelvic lymph nodes. Her cancer was classified as Stage II. Somatic BRCA1/2 testing was negative.

She started carboplatin plus paclitaxel chemotherapy. After the first cycle, her liver enzymes rose sharply, and other common causes of liver injury were excluded. The care team diagnosed paclitaxel-related hepatotoxicity and treated the liver injury while monitoring her closely.

Once the liver tests improved, chemotherapy was restarted after a delay with a reduced paclitaxel dose. She tolerated the remaining treatment with manageable liver-test abnormalities and completed all six planned chemotherapy cycles. She then moved to routine surveillance.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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