Stage IB squamous lung cancer: sleeve lobectomy complicated by pulmonary artery pseudoaneurysm

Patient Info: Anonymized, Male, 50s | Stage I

As of October 2013, he had normal quality of life and was cancer-free 1 year after the first operation, despite postoperative pulmonary artery pseudoaneurysm, completion pneumonectomy, and empyema treatment.

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Stage IV Ovarian Cancer: Bre's Patient Story

Patient Info: Bre Tipps, female, Under 40 | Stage IV

A recent CT scan showed the remaining tumors calcifying and dying during hormonal therapy, although the patient expected to need ongoing ovarian cancer treatment.

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Stage IV primary gastric choriocarcinoma reaches 9 years with no evidence of disease

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: liver, lungs

She remained alive with no evidence of disease for 9 years after radiofrequency ablation, more than 9 years after the original diagnosis.

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Early gastric cancer returns in bone after an 8-year disease-free interval

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: bone

After an 8-year disease-free interval, he developed bone metastasis, received chemotherapy, developed disseminated intravascular coagulopathy and died in August 2011, nearly 10 years after the original diagnosis.

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Breast invasive ductal carcinoma with coexisting inflammatory myofibroblastic tumor: disease-free after mastectomy, TAC, and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: Breast cancer: ER/PR-positive with HER2 2+ and p53-positive. Separate inflammatory myofibroblastic tumor had ALK/vimentin/actin/S-100 markers.

As of August 2013, she remained disease-free 2 years after modified radical mastectomy, 6 courses of TAC chemotherapy, and tamoxifen.

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Localized hormone receptor-positive breast cancer disease-free 5 years after endocrine therapy switch

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-positive; PR-positive; HER2-negative; low Ki-67; Oncotype DX 12

After lumpectomy and 36 months of adjuvant hormonal treatment, she remained disease-free at her last examination in March 2013, 5 years after diagnosis.

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ER/PR-positive mucinous breast cancer treated with mastectomy and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: ER-positive; PR-positive; HER2/neu not overexpressed; no pathogenic BRCA1 or BRCA2 mutations identified; chromosome 13q34 duplication

After radical right mastectomy with nipple and areola preservation followed by tamoxifen, she showed no evidence of local recurrence or metastasis of breast cancer.

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Ovarian Granulosa Cell Tumor Spreads to the Spine and Kidney

Patient Info: Anonymized, female, 40s | Stage IV

Metastatic Site: spine, kidney

Years after the original ovarian tumor, metastatic granulosa cell tumor was confirmed in the L1 vertebra and later in the left kidney.

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Stage III signet-ring gastric cancer is diagnosed only after repeated negative biopsies

Patient Info: Anonymized, Male, 50s | Stage III

He was alive at the latest follow-up after surgery and 8 courses of XELOX chemotherapy.

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Stage II signet-ring gastric cancer is found after repeated negative biopsies in a 52-year-old woman

Patient Info: Anonymized, Female, 50s | Stage II

She was alive at the latest follow-up after surgery.

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Gastric adenocarcinoma spreads to the liver and esophageal mucosa

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver, esophageal mucosa

The metastatic disease progressed despite 3 cycles of second-line docetaxel plus cisplatin.

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Ovarian Dysgerminoma Treatment Followed by Bleomycin-Related Skin Changes

Patient Info: Anonymized, female, Under 40

A 23-year-old woman treated for ovarian dysgerminoma developed persistent streak-like skin darkening after bleomycin-containing chemotherapy.

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Stage IV ER/PR-positive mucinous breast cancer: long-term no evidence of disease after surgery, AFTV, radiation, CEF, and endocrine therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; delayed-type hypersensitivity to AFTV became pseudo-positive after vaccination and remained pseudo-positive 5.4 years later

Metastatic Site: Th7 vertebra

More than 6 years after primary surgery, she remained well with no evidence of vertebral metastasis activity, new metastasis, or local recurrence.

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Recurrent Ovarian Cancer With Tumor Lysis Syndrome After Chemotherapy

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: lungs

After 9 years of stable disease, the ovarian cancer progressed extensively and the first cycle of renewed chemotherapy was complicated by severe tumor lysis syndrome and multiorgan illness.

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ER-positive breast cancer recurrence with renal metastasis inside angiomyolipoma

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive; mammaglobulin-positive; e-cadherin-positive; GCDFP-15-positive; melan A positive in angiomyolipoma component

Metastatic Site: right subpectoral lymph node, left kidney

At 7 months after nephrectomy, she continued anti-estrogen hormonal therapy with no demonstrable progression of disease; surgical excision of the subpectoral lymph node was offered but declined.

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BRCA1-associated right invasive ductal carcinoma followed by left acinic cell carcinoma of the breast

Patient Info: Anonymized, Female, 40s

Biomarkers: Constitutional BRCA1 mutation. Right breast cancer was ER/PR positive, HER2 negative; later left tumor was triple-negative with TP53 change.

After treatment for right invasive ductal carcinoma and later contralateral acinic cell carcinoma, she was alive and well 19 months after the acinic cell carcinoma surgery, with no evidence of disease while continuing hormonal therapy.

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Stage IIIA squamous lung cancer with later kidney and paraaortic lymph node metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Squamous lung cancer markers supported the diagnosis; TTF-1, CK7 and CK20 were not seen; Ki-67 >10%.

Metastatic Site: left renal parenchyma, paraaortic lymph nodes

After surgery, 4 cycles of cisplatin plus vinblastine, and mediastinal radiotherapy, she had a 10-month disease-free interval before biopsy-confirmed metastatic squamous lung carcinoma appeared in the left kidney with paraaortic lymph node enlargement.

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Rare Ovarian Choriocarcinoma Treated With Surgery and Chemotherapy

Patient Info: Anonymized, female, Under 40

Her hCG level normalized during chemotherapy, and she remained without evidence of disease 5 years after diagnosis.

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Stage III Ovarian Cancer Diagnosed With a Separate Vaginal Cancer

Patient Info: Anonymized, 50s | Stage III

A whole-body PET scan 4 weeks after treatment found no active malignant disease, and she continued regular follow-up.

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Sigmoid colon cancer: complete response after repeated metastatic recurrences and multimodal therapy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF status not reported; CEA elevation used for recurrence monitoring

Metastatic Site: left lung, mediastinal lymph nodes, left adrenal…

By 2011, all metastatic lesions had achieved complete response; nearly 1 year after the last adrenal irradiation, no recurrence had been detected.

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Ovarian Cancer That Spread to the Cerebellum 10 Years Later

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: right cerebellum

After removal of the cerebellar metastasis, her headache and vertigo improved and she subsequently received whole-brain radiation.

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Synchronous T3N0 colon cancers causing intussusception treated with colectomy and oral UFUR

Patient Info: Anonymized, Female, 50s | Stage II

Biomarkers: lymphovascular invasion positive; perineural invasion positive; anemia at presentation

After surgery for synchronous T3N0 colon adenocarcinomas and adjuvant oral UFUR, no recurrent symptoms or signs were noted at 12-month follow-up.

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ER/PR-positive breast cancer with bilateral ovarian metastases controlled after oophorectomy and aromatase inhibitor

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; CK7-positive; gross cystic disease fluid protein-15-positive; CK20-negative

Metastatic Site: bilateral ovaries

After bilateral oophorectomies and aromatase inhibitor therapy, pleural effusion resolved, CEA and CA 15-3 decreased below the normal upper limit, and she remained well with no further recurrence for 40 months.

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Ovarian serous adenocarcinoma returns as a solitary gastric metastasis more than 12 years later

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: stomach

At the latest follow-up, she had no recurrence after resection of the gastric metastasis, more than 12 years after her original ovarian-cancer surgery.

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