Metastatic lobular breast cancer to gynecologic sites: disease-free after surgery and chemotherapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-negative; HER2/C-Erb-B2-negative

Metastatic Site: vagina, uterus, ovaries

After treatment of vaginal, uterine, and ovarian metastases from lobular breast cancer, she was free from disease 12 months after completion surgery.

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Mucinous Ovarian Cancer Treated During Pregnancy

Patient Info: Anonymized, female, Under 40 | Stage I

The woman and her baby were followed for more than 5 years, and the mother had no evidence of ovarian cancer recurrence during that period.

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Hormone-positive breast cancer with axillary recurrence responding to hyperthermia, radiation, and chemotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: ER-positive; PR-positive; HER2-negative

The left axillary recurrence enlarged during weekly paclitaxel and radiotherapy, then became nearly flat and was assessed as a complete response 8 weeks after adding hyperthermia.

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Stage III sigmoid colon invasive micropapillary carcinoma treated with sigmoidectomy and modified FOLFOX6

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: CEA normal; CA 19-9 normal; MUC1 inside-out staining pattern in micropapillary component

After diagnostic endoscopic resection, sigmoidectomy with regional lymph node resection, and 6 cycles of modified FOLFOX6, he was in good condition with no evidence of recurrence 12 months after surgery.

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Papillary Thyroid-Type Cancer Arising in Struma Ovarii

Patient Info: Anonymized, female, 40s

Six months after surgery, imaging showed no recurrence or metastasis and thyroglobulin was undetectable, supporting remission.

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Colorectal Cancer: Jennifer's Survivor Story

Patient Info: Jennifer Gerres, Female, Under 40

As of June 2012, Jennifer had undergone laparoscopic sigmoid colectomy for sigmoid colon cancer, her pathology report was all clear, and she described going from diagnosis to no cancer within 2 weeks.

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Stage IV EBV-positive lymphoepithelioma-like lung cancer with brain metastasis

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EBV-positive by in-situ hybridization

Metastatic Site: brain, retroperitoneal/posterior mediastinal soft…

Remained well and disease-free 6 months after resection of the retroperitoneal/posterior mediastinal metastasis and 8 years after initial presentation.

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Ovarian Granulosa Cell Tumor Recurs 22 Years After Initial Surgery

Patient Info: Anonymized, female, 60s

A metastatic granulosa cell tumor recurrence was confirmed 22 years after her original surgery and was treated with maximal debulking surgery.

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Stage IIIA pleomorphic lung cancer treated with surgery, chemotherapy, and radiation

Patient Info: Anonymized, Male, Under 40 | Stage III

Alive 14 months after surgery without evidence of tumor recurrence after complete resection, adjuvant chemotherapy, oral S-1, and radiation.

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Stage IV lung squamous cell carcinoma with liver metastasis treated with chemotherapy and 90Y radioembolization

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: liver

After treatment for liver metastasis, PET CT 2 months after 90Y radioembolization showed complete tumor response without residual tumor, and she was alive without active disease.

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Gastric Cancer: Johanna's Patient Story

Patient Info: Johanna Chelcun, Female, Under 40

She gradually rebuilt her strength and ran a half-marathon about 10 months after surgery.

Gastric Cancer: Laura's Patient Story

Patient Info: Laura McFetridge Ayala, Female, Under 40

Biomarkers: CDH1 mutation

She was recovering after total gastrectomy and adapting to life without a stomach.

Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Long-Term Maintenance Therapy

Patient Info: Anonymized, 50s | Stage III

Biomarkers: BRCA1 mutation

After long-term maintenance therapy, she had no evidence of ovarian cancer at the latest follow-up.

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Metastatic lobular breast cancer to bladder trigone: partial response to tamoxifen

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: progesterone receptor-positive; genetic testing including BRCA1 negative

Metastatic Site: bladder trigone

As of January 2012, urge incontinence had resolved and PET showed decreased activity in the breast and bladder trigone lesions nearly 10 months after starting tamoxifen, consistent with clinical and partial radiologic remission.

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Recurrent Stage III Ovarian Cancer in a BRCA2 Carrier Treated Over Many Years

Patient Info: Anonymized, 40s | Stage III

Biomarkers: BRCA2 mutation

She later developed a separate aggressive oral squamous cell carcinoma and died in 2011 from acute airway obstruction during progression of that cancer.

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Stage III Triple-Negative Breast Cancer: Bridgette's Survivor Story

Patient Info: Bridgette, Female, 60s | Stage III

Biomarkers: Triple-negative breast cancer

Bridgette completed treatment and described herself as being in remission and free of cancer. Fear of recurrence continued to affect her survivorship.

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Stage IV large-cell lung cancer with adrenal metastasis: no recurrence after R0 surgery

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Marker profile supported large-cell lung carcinoma: CK7/CEA/Ber-EP4 positive, with neuroendocrine and prostate markers negative.

Metastatic Site: left adrenal gland

Six months after combined lung and adrenal surgery with R0 resection, he had no evidence of recurrence.

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Stage III Ovarian Cancer in a BRCA1 Carrier With Long-Term Disease Control

Patient Info: Anonymized, 60s | Stage III

Biomarkers: BRCA1 mutation

At the latest follow-up in January 2012, she had no recurrence of ovarian cancer and was well.

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Recurrent Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Multiple Therapies

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

By late 2011, hilar nodal disease was slowly progressing and bevacizumab was started for the recurrent ovarian cancer.

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Recurrent Stage III Ovarian Cancer Complicated by Severe Kidney Injury

Patient Info: Anonymized, female, 70+ | Stage III

After further intra-abdominal cancer progression and severe kidney injury, she developed seizures, encephalopathy, and limb ischemia and died 1 week after hospitalization in May 2011.

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Recurrent Ovarian Cancer With Severe Kidney Injury During Long-Term Treatment

Patient Info: Anonymized, female, 60s

Despite severe chronic kidney disease, later chemotherapy produced some regression of the progressing ovarian cancer with each sequential regimen.

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Male DCIS breast cancer treated with mastectomy and negative sentinel node

Patient Info: Anonymized, Male, 60s | Stage 0

Biomarkers: ER-positive; PR-positive

Completed surgical treatment for Stage 0 DCIS with negative sentinel lymph node biopsy and clear margins; no additional cancer-directed therapy was described.

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Gastric adenocarcinoma first presents with painful eye and orbital metastases

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: left uvea, orbit, sclera, optic nerve

He died 6 months later after treatment for metastatic gastric cancer.

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Recurrent HER2-amplified breast cancer: complete remission on trastuzumab-based therapy

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Primary tumor was ER/PR negative and HER2 not amplified. Recurrent lymph-node disease became ER/PR positive and HER2 amplified by FISH.

Metastatic Site: left axillary and infraclavicular lymph nodes

After HER2-amplified nodal recurrence, paclitaxel plus trastuzumab produced complete clinical remission; she continued trastuzumab monotherapy with tolerable neuropathy.

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