Ovarian serous adenocarcinoma returns as a solitary gastric metastasis more than 12 years later

This ovarian cancer diagnosis at a glance

Stage at diagnosis
Stage IV
Subtype
Adenocarcinoma
Sex
Female
Spread to
stomach
Treatment
surgery and chemotherapy
Outcome
Cancer-Free / NED

Treatment course, step by step

  1. Underwent cytoreductive surgery for ovarian adenocarcinoma in 1999 followed by 10 cycles of cisplatin plus cyclophosphamide.
  2. Received another 10 cycles of chemotherapy in 2006 when CA-125 rose again.
  3. Underwent local gastrectomy in 2011 for a solitary gastric metastasis from the ovarian cancer.

What happened, in summary

A 61-year-old woman had originally undergone cytoreductive surgery for ovarian adenocarcinoma in 1999, followed by 10 cycles of cisplatin plus cyclophosphamide chemotherapy. When her CA-125 level rose again in 2006, she received another 10 cycles of chemotherapy using paclitaxel, cyclophosphamide, carboplatin and bleomycin.

In December 2011, CA-125 increased again even though she had no gastrointestinal symptoms. PET/CT showed a single metabolically active mass in the gastric antrum and no other abnormal lesions in the abdomen or pelvis. She underwent local gastrectomy.

Pathology showed serous papillary adenocarcinoma infiltrating the stomach. The tumor’s staining pattern supported metastasis from the previous ovarian cancer rather than a new primary gastric cancer. Her postoperative recovery was uncomplicated. At the latest follow-up, she had no recurrence after removal of the gastric metastasis. This placed her more than 12 years beyond the original ovarian-cancer surgery despite a late Stage IV recurrence to the stomach.

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This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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