Gastric adenocarcinoma is found after repeated ulcer biopsies remain negative

Patient Info: Anonymized, Male, 40s

He recovered well after surgery, received adjuvant chemotherapy and continued regular outpatient follow-up.

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Gastric Cancer: Gretchen's Survivor Story

Patient Info: Gretchen Borzi, Female, 40s

Biomarkers: germline CDH1 mutation

The cancers were localized with no lymph-node spread, and Gretchen was considered cured after gastrectomy.

Invasive Lobular Carcinoma: Gretchen's Survivor Story

Patient Info: Gretchen Borzi, Female

Biomarkers: germline CDH1 mutation

The invasive focus measured less than 0.75 mm and had been removed during biopsy; surgery found no nodal spread.

Ovarian Cancer Recurrence Complicated by a Benign Surgical Stitch Reaction

Patient Info: Anonymized, female, 40s | Stage III

Diffuse peritoneal relapse was confirmed, and she remained on third-line chemotherapy with persistent evidence of ovarian cancer.

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Gastric adenocarcinoma causes SIADH through ectopic ADH secretion

Patient Info: Anonymized, Male, 60s

Biomarkers: ADH-positive tumor cells

He died from gastric-cancer progression 1.6 years after diagnosis despite surgery and chemotherapy.

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Ovarian Cancer Recurs as a Solitary Splenic Metastasis Six Years Later

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: spleen

After removal of the solitary splenic metastasis, she returned to gynecologic oncology and received another course of paclitaxel and carboplatin.

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Gastric cancer recurs in the spermatic cord 7 years after treatment

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: epididymis, spermatic cord

At 26 months after orchiectomy, he was doing well with no evidence of recurrence, more than 9 years after his original gastric-cancer surgery.

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Gastric cancer recurs in the spermatic cord after 6 years without recurrence

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: spermatic cord

At 20 months after orchiectomy, he was stable with no recurrence, more than 7 years after treatment of his original gastric cancer.

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Gastric adenocarcinoma recurs in the adrenal gland 6 years after gastrectomy

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: left adrenal gland

At 13 months after resection of the adrenal metastasis, imaging and tumor-marker follow-up found no evidence of recurrence, placing him more than 7 years beyond the original gastrectomy.

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Signet-ring gastric cancer with repeated recurrences and a late adrenal metastasis

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: left adrenal gland

At 12 months after resection of the adrenal metastasis, no definite recurrence was found, roughly 7 years after the original gastric-cancer surgery.

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Pediatric triple-negative breast carcinoma: modified radical mastectomy and tumor-free follow-up

Patient Info: Anonymized, Female, Under 40

Biomarkers: ER-negative; PR-negative; HER2-negative

As of April 2014, she was tumor-free after modified radical mastectomy and axillary clearance for pediatric triple-negative breast carcinoma.

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Fertility-Sparing Surgery for Stage I Endometrioid Ovarian Cancer

Patient Info: Anonymized, female, Under 40 | Stage I

Biomarkers: BRCA1/2 negative

She had two spontaneous pregnancies after treatment and remained without evidence of disease at 46 months.

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Fertility-Sparing Surgery for Stage I Immature Ovarian Teratoma

Patient Info: Anonymized, female, Under 40 | Stage I

She later conceived spontaneously, delivered a healthy baby, and had no evidence of disease at 19 months of follow-up.

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Synchronous Stage IA breast cancer and Stage IIA lung adenocarcinoma: disease-free after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: Breast tumor: ER/PR positive, HER2 negative. Lung tumor: KRAS/EGFR wild type, ALK rearrangement not detected.

As of April 2014, more than 2 years of follow-up showed no recurrent disease after treatment of synchronous Stage IA breast cancer and Stage IIA lung adenocarcinoma.

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Stage I gastric adenocarcinoma treated with endoscopic resection and additional laparoscopic gastrectomy in situs inversus

Patient Info: Anonymized, Male, 40s | Stage I

At 18 months after surgery, he was doing well without recurrent gastric cancer.

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Stage III low rectal cancer: complete response to mFOLFOX6 plus panitumumab and sphincter-preserving surgery

Patient Info: Anonymized, Male, 50s

Biomarkers: KRAS wild-type

As of March 2014, he was alive without evidence of recurrence 3 months after surgery, after complete pathologic response to neoadjuvant mFOLFOX6 plus panitumumab followed by intersphincteric resection and adjuvant UFT/leucovorin.

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Mixed epithelial and mesenchymal metaplastic breast carcinoma: no recurrence 1 year after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Mixed metaplastic breast cancer: epithelial part ER/PR/HER2-positive; mesenchymal part ER/PR-negative with weak HER2. Ki-67 ~20%.

As of March 2014, she was doing well with no recurrence or metastasis 1 year after modified radical mastectomy, adjuvant CEF/Taxotere chemotherapy, and tamoxifen.

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Stage III BRCA1 Ovarian Cancer: Meredith's Survivor Story

Patient Info: Meredith Ippolito, female | Stage III

Biomarkers: BRCA1 mutation

Meredith was told she was cancer-free in April 2009 and continued follow-up visits every 6 months.

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Pediatric Stage I intermediate-grade lung mucoepidermoid carcinoma: lobectomy with 1-year no recurrence

Patient Info: Anonymized, Male, Under 40 | Stage I

Biomarkers: Lymphovascular invasion negative; lymph node metastasis negative; PAS-positive mucin-rich cells

The child had no signs of tumor recurrence 1 year after lobectomy and received no adjuvant therapy because the tumor was localized and low/intermediate grade.

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Stage IIIB lung adenocarcinoma with separate papillary renal cell carcinoma: doing well more than 6 years after revised diagnosis

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: Lung tumor: TTF-1-positive; PET-avid. Kidney lesion: PET-negative; later papillary renal cell carcinoma. No lung molecular biomarkers reported.

As of February 2014, she was doing well more than 6 years after the initial diagnosis, after the diagnosis was revised from presumed Stage IV lung cancer to Stage IIIB lung adenocarcinoma plus a separate papillary renal cell carcinoma.

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Stage IB epithelial-myoepithelial lung carcinoma: no recurrence after VATS lobectomy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: Epithelial-myoepithelial lung carcinoma: EMA, actin and focal S-100 staining supported the diagnosis.

As of February 2014, she had no local recurrence or distant metastasis 16 months after video-assisted thoracoscopic left upper lobectomy and lymph node dissection for Stage IB epithelial-myoepithelial lung carcinoma.

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Gastric Cancer: Sara's Patient Story

Patient Info: Sara Souto Strom, Female

After treatment, Sara returned to an active life and continued her work as a cancer researcher.

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Cecal cancer revealing Muir-Torre syndrome with an MSH2 mutation

Patient Info: Anonymized, female

Biomarkers: MSI-high; loss of MSH2 expression; truncating MSH2 mutation

A woman with multiple sebaceous tumors and a strong family history of colorectal cancer was found to have MSI-high cecal cancer and an MSH2 mutation consistent with Muir-Torre syndrome.

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Seven synchronous early gastric cancers with extensive lymph-node involvement in an 85-year-old man

Patient Info: Anonymized, Male, 70+

An 85-year-old man was found to have seven synchronous early gastric adenocarcinomas, with 28 of 48 removed lymph nodes containing metastases despite shallow primary-tumor invasion.

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