Severe Kidney Injury During Oxaliplatin Treatment for Metastatic Colorectal Cancer

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: liver

His kidney function returned to baseline 2 months after the acute injury, and colorectal cancer treatment continued with 5-FU and leucovorin after oxaliplatin was stopped.

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Mixed adenocarcinoma-neuroendocrine gastric cancer progressing after multiple treatments

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver

After progression through several treatments and development of liver metastasis, he was taking apatinib at the latest update.

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Oxaliplatin-Related Muscle Breakdown During Colorectal Cancer Treatment

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: CEA 1.01 ng/mL; CA 19-9 <0.6 U/mL

He recovered fully from rhabdomyolysis, completed adjuvant capecitabine, and entered follow-up without evidence of cancer recurrence.

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Metastatic Colorectal Cancer Treatment Complicated by Severe Lung Inflammation

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: KRAS wild type; NRAS wild type

Metastatic Site: liver

He recovered from the severe treatment-related lung inflammation, was weaned off oxygen within 1 month, and continued oncology follow-up while living with Stage IV colorectal cancer.

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HER2-amplified metastatic colon cancer treated with afatinib after several therapies

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: RAS wild-type; BRAF wild-type; HER2 amplification; HER2 mutation

Metastatic Site: liver|abdominal wall|lung

After multiple treatment lines and a 3-month period of stable disease on afatinib, the cancer progressed again. He died in January 2018 from severe lung infection and kidney failure.

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Perforated gastric cancer treated with staged surgery, HIPEC and chemotherapy

Patient Info: Anonymized, male, 60s

Adjuvant capecitabine plus oxaliplatin began one month after surgery. At the 6-month follow-up, he was eating without discomfort and had no other symptoms.

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Colon Cancer With Lung Metastasis Alongside a Separate Thyroid Cancer

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: Rising CEA

Metastatic Site: lungs

A 64-year-old woman had colon cancer involving the lungs while a separate follicular-variant thyroid cancer involved the kidney.

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Metastatic Colon Cancer With Painful Skin Fissures During Cetuximab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS unmutated

Metastatic Site: lungs|pericardium|mediastinal lymph nodes

He died not long after cetuximab was stopped following cancer progression.

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Teenage colon cancer initially mistaken for anorexia nervosa

Patient Info: Anonymized, Female, Under 40 | Stage III

Biomarkers: Loss of MSH2 and MSH6 expression; microsatellite instability; MSH2 variant of uncertain significance suspected to affect splicing; Lynch syndrome diagnosis

She remained in remission 3 years after surgery.

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Locally advanced transverse colon cancer complicated by a colocutaneous fistula

Patient Info: Anonymized, Female, 60s | Stage III

After initially recovering from surgery, she developed a respiratory infection, sepsis and metabolic encephalopathy and died after cardiorespiratory arrest on postoperative day 12.

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Colon cancer chemotherapy complicated by a severe manic episode

Patient Info: Anonymized, Male, 40s | Stage III

He completed chemotherapy without further affective episodes on the revised regimen and remained under regular follow-up.

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Robotic gastric cancer surgery in a man with situs inversus totalis and no recurrence at 2.5 years

Patient Info: Anonymized, Male, 50s

Biomarkers: HER2 2+

At 2.5 years after surgery, there was no recurrence.

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Stage IV Colorectal Adenocarcinoma: Patricia's Patient Story

Patient Info: Patricia, 50s | Stage IV

Living with Stage IV colorectal cancer after about 6.5 years of intermittent chemotherapy and multiple local treatments; on a treatment holiday while awaiting December 2024 scans.

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Gastric cancer causes severe pulmonary hypertension that improves rapidly with imatinib

Patient Info: Anonymized, Female, 50s | Stage IV

She died from systemic metastatic gastric cancer 7 months after the pulmonary vascular presentation.

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Stage III gastric adenocarcinoma later spreads to the gingiva and responds to local treatment

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: HER2-negative

Metastatic Site: gingiva

The gingival metastasis disappeared after treatment, and the disease remained stable through March 2017.

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Metastatic Colorectal Cancer Treated With S-1 After 5-FU Cardiotoxicity

Patient Info: Anonymized, male, 60s

Biomarkers: RAS-mutant

After progression in the liver despite prior systemic and liver-directed treatment, he started S-1, oxaliplatin and bevacizumab; the first cycle caused no cardiac complication and treatment continued as an outpatient.

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Metastatic Colon Cancer With Tumor Thrombus Extending Into the Right Atrium

Patient Info: Anonymized, female, 40s

Biomarkers: BRAF wild-type, KRAS wild-type, NRAS wild-type

Her metastatic colorectal cancer progressed despite multiple treatment lines. Supportive care alone was chosen after her performance status deteriorated, and she later died from multiorgan failure in the setting of metastatic cancer.

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Recurrent Stage III Ascending Colon Cancer With a Duodenocolic Fistula in a 33-Year-Old Man

Patient Info: Anonymized, male, Under 40 | Stage III

Six months after surgery, he returned with advanced recurrent disease that could not be resected; feeding procedures were performed and he was sent home with plans for palliative care.

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Stage IV Signet Ring Gastric Cancer Presenting With DIC and Severe Anemia

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: bone marrow

His coagulation abnormalities and anemia improved after chemotherapy, and he was discharged in stable condition to continue treatment and oncology follow-up.

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Metastatic Gastric Cancer Treatment Complicated by Acute Hypertension During Ramucirumab

Patient Info: Anonymized, male, 60s

After progression on first-line chemotherapy, he had started second-line ramucirumab-based treatment when an acute hypertensive infusion reaction was documented.

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Stage IV HER2-negative gastric adenocarcinoma complicated by acute arterial thrombosis during chemotherapy

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: HER2-negative

Metastatic Site: peritoneum, retroperitoneal lymph nodes

After recovering from acute arterial thrombosis, he restarted cancer treatment with docetaxel and remained well without further complications at the latest follow-up.

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Stage IV gastric adenocarcinoma causes inferior vena cava compression and severe leg swelling

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: omentum

At the latest follow-up, she was receiving cycle 5 of paclitaxel and trastuzumab. Her appetite, energy and leg edema had improved, although abdominal bloating persisted.

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Severe gastrointestinal bleeding and perforation during apatinib treatment for metastatic gastric cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 IHC 2+; FISH negative for HER2 amplification

Metastatic Site: peritoneum, ileum

She died on February 23, 2015 after gastrointestinal perforation, septic shock and multiple organ dysfunction during progressive metastatic disease.

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Sigmoid colon cancer with later inguinal lymph-node metastasis: surgery, FOLFOX, FOLFIRI, and cetuximab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: CEA was elevated at diagnosis and recurrence. Metastatic lymph node was CK20 positive/CK7 negative; EGFR mutation status not reported.

Metastatic Site: left inguinal lymph node

Apparently disease-free 8 months after surgical removal of the left inguinal lymph-node metastasis followed by FOLFIRI plus cetuximab.

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