Kidney Disease During Treatment for Metastatic Gastric Cancer

Patient Info: Anonymized, Male, 70+ | Stage Metastatic/Advanced

Metastatic Site: liver

His condition worsened with nephrotic syndrome, malnutrition, treatment side effects, and progressing metastases. He died 5 months after the kidney biopsy following a fatal cerebral bleed.

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Kidney Injury During Nivolumab Treatment for Stage IV Gastric Cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Kidney function and proteinuria improved after nivolumab was stopped, but the gastric cancer progressed. Restarted nivolumab was ineffective, and treatment was changed to irinotecan.

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Colorectal Cancer: Barbara's Survivor Story

Patient Info: Barbara, Female, 40s

As of October 2021, Barbara described life after completed colon-cancer treatment, including survivorship, parenting, and a stronger perspective; recurrence was not described in this edited video.

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Stage IV gastric cancer treated with chemotherapy and hyperthermia in a patient with a vagus nerve stimulator

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: para-aortic lymph nodes, peritoneum

The gastric tumors and lymph-node disease initially shrank during treatment, but peritoneal dissemination developed. He died from progressive gastric cancer 8 months after treatment began.

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Stage IV gastric cancer with low platelets managed so chemotherapy could continue

Patient Info: Anonymized, female, 60s | Stage IV

Chemotherapy was able to continue after partial splenic embolization, but the gastric cancer later progressed and she died from the disease.

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Stage IV gastric cancer with low platelets managed so chemotherapy could continue — Case 2

Patient Info: Anonymized, female, 70+ | Stage IV

After partial splenic embolization, her platelet count recovered and thrombocytopenia did not recur. She was receiving second-line ramucirumab plus paclitaxel at the latest follow-up.

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Stage IV gastric cancer with gastric outlet obstruction treated with a stent

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: para-aortic lymph nodes

The second stent allowed her to continue eating solid food. She died from progressive gastric cancer 3 months after the repeat stent procedure.

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Locally invasive gastric cancer treated with chemotherapy followed by curative surgery

Patient Info: Anonymized, male, 70+ | Stage III

Biomarkers: HER2-negative

Six months after surgery, CT showed no recurrence.

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Stage III gastric sarcomatoid carcinoma treated with surgery and chemotherapy

Patient Info: Anonymized, female, 50s | Stage III

She was alive and healthy at telephone follow-up 3 years after surgery.

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Severe immune thrombocytopenia during treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: KRAS-mutated; microsatellite stable; BRAF-wild type.

Metastatic Site: bilateral ovaries; pelvis; peritoneum; mesenteric…

After multiple metastatic recurrences and treatment changes, she died from progressive colon cancer; oxaliplatin had been permanently stopped after antibody-confirmed immune thrombocytopenia.

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Bilateral adrenal bleeding during bevacizumab treatment for metastatic colon cancer

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: RAS-mutant; BRAF-wild type; microsatellite stable.

Metastatic Site: peritoneum; liver; lung

Despite multiple systemic and local treatments, his metastatic colon cancer progressed in the liver and peritoneum, and he died from disease progression in November 2018.

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Ramucirumab and paclitaxel for metastatic gastric cancer in a patient receiving hemodialysis

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver, distant lymph nodes

After about 16 months of disease control on paclitaxel plus ramucirumab, multiple liver metastases and distant lymph nodes progressed. Third-line irinotecan was stopped after severe toxicity, and supportive care followed.

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Stage IV Colorectal Cancer: Lee's Survivor Story

Patient Info: Lee Jones, Male, 50s | Stage IV

Metastatic Site: Liver

As of February 2021, Lee reported no evidence of colon cancer since 2011 after treatment for Stage IV colon cancer with liver metastases, recurrence, chemotherapy, colon surgery, and liver surgery.

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Emergency Repair of a Long-Term Perineal Hernia After Rectal Cancer Surgery

Patient Info: Anonymized, Female, 70+ | Stage IV

Metastatic Site: lungs

She lived with metastatic rectal cancer and received community palliative care after becoming too frail for further chemotherapy.

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Stage IV Colorectal Cancer: Maria's Patient Story

Patient Info: Maria | Stage IV

Metastatic Site: lungs

After colorectal cancer spread to the lungs, completed 6 months of chemotherapy and is being monitored with CT scans every 3 months.

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Colon Cancer With an MLH1 Deletion and Lynch Syndrome

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: dMMR with loss of MLH1 and PMS2. Familial MLH1 c.1057_1060delGCTG frameshift deletion identified; its clinical significance had not previously been reported.

The colon cancer progressed rapidly despite postoperative and second-line therapy, and he died from multiple organ failure one week after pembrolizumab was started.

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Dural metastasis causing seizures after treatment for signet-ring gastric cancer

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: dura mater

She died 16 days after hospital admission for neurologic symptoms, roughly 8 months after the original gastric-cancer diagnosis, following rapid deterioration from diffuse dural metastatic disease.

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Cutaneous lymphatic spread after Stage III gastric cancer with signet-ring cells

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: bone, distant lymph nodes, skin

After metastatic spread to bone, distant lymph nodes and skin, she developed respiratory failure and died despite palliative treatment.

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Nivolumab-related IgA kidney disease during treatment for Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

The gastric tumor regrew while nivolumab was withheld. Kidney function improved with steroids, but recurrent pneumonia and poor performance status prevented immunotherapy from restarting.

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Colon Cancer Stories: Barbara Majeski

Patient Info: Barbara Majeski, Female, 40s | Stage III

As of May 2020, Barbara was approaching the 5-year mark after Stage III colon cancer, with blood tests every 6 months and annual scans reported as good/clear.

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Portal-vein thrombosis after surgery and chemotherapy for Stage III gastric cancer — Case 1

Patient Info: Anonymized, female, 40s | Stage III

At 6 months of follow-up after treatment for the thrombosis, no hepatic decompensation or liver cirrhosis had developed.

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Portal-vein thrombosis after surgery and chemotherapy for Stage III gastric cancer — Case 2

Patient Info: Anonymized, female, 60s | Stage III

Two months into follow-up after the thrombosis, no hepatic decompensation or liver cirrhosis had been identified.

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Clival skull-base metastasis during treatment for Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: HER2-negative

Metastatic Site: peritoneum, cervical lymph nodes, pelvic bone, lungs,…

At publication he was alive on fourth-line treatment, with no disease progression for 6 months after the clival metastasis was treated and with sustained improvement in his cranial-nerve symptoms.

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Stage IV gastric cancer presenting with chylothorax and lymphedema

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: distant lymph nodes, pleura, peritoneum

She died 6 months after the Stage IV gastric-cancer diagnosis despite chemotherapy and repeated treatment of the malignant pleural effusions.

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