Metastatic Colorectal Cancer With Leucovorin Hypersensitivity During Cetuximab-FOLFOX Treatment

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: EGFR mutation detected; no KRAS, NRAS or BRAF mutations detected

Metastatic Site: lung

After 18 cycles of cetuximab plus FOLFOX, her metastatic colorectal cancer was stable and treatment continued with modifications for leucovorin hypersensitivity.

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Stage IV Colorectal Cancer: Jeff's Patient Story

Patient Info: Jeff Williams, Male, 50s | Stage IV

Metastatic Site: Liver; lungs

As of December 2023, Jeff was living with recurrent Stage IV colorectal cancer, had recently developed more lung tumors, continued chemotherapy locally every 2 weeks, and returned to UT MD Anderson every 3 months for scans.

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Stage III Colorectal Cancer: Stephanie's Survivor Story

Patient Info: Stephanie, Female, Under 40 | Stage III

As of November 2023, Stephanie reported that her oncologist said her cancer was in remission after surgery and chemotherapy, with CT/lab follow-up and a PET scan for reassurance.

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Stage III Colorectal Cancer: Barbara's Survivor Story

Patient Info: Barbara, Female, 40s | Stage III

As of November 2023, Barbara described herself as a colon cancer survivor in year 4 after surgery and chemotherapy, continuing surveillance scans and living with scan anxiety and lasting treatment effects.

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Stage IV Breast Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: BRCA1-negative

Metastatic Site: Bone marrow

As of November 2023, Sherri had no evidence of disease on recent breast cancer scans but remained on targeted treatment every 3 weeks and had started oxaliplatin after surgery for a separate Stage III colon cancer.

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Stage IV HER2-Positive Multiple primaries: metastatic Breast Cancer + Colon/Colorectal Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: HER2-positive breast cancer; colon cancer Signatera positive before surgery and negative after surgery

Metastatic Site: Bone marrow

As of October 2023, Sherri had no evidence of disease on recent scans for HER2-positive metastatic breast cancer but was receiving oxaliplatin/Oxyplatin chemotherapy and transfusions for a separate early Stage III colon cancer.

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Hidden colon cancer first discovered through a rare brain/nerve inflammation

Patient Info: Anonymized, Male | Stage II

At 1 year he was asymptomatic and off treatment, with no neurological deficits and a normal repeat PET scan.

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Painful eye metastasis from Stage IV gastric cancer

Patient Info: Anonymized, male | Stage IV

Metastatic Site: bone, choroid of left eye

The eye surgery relieved his pain, but he died 2 months later.

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My Stage 4 Colorectal Cancer Story: How I Never Lost Hope

Patient Info: Jason Randall, Male | Stage IV

Metastatic Site: Liver; lungs; bone/sacrum

As of June 2023, Jason had a negative Signatera test, CT scans showing 9 months with no evidence of disease, and about 2.5 years off chemotherapy after Stage IV colorectal cancer treatment and lung ablation.

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Stage II Colorectal Cancer: Amanda's Survivor Story

Patient Info: Amanda, Female, Under 40 | Stage II

Biomarkers: Genetic mutations involving colon, kidney, and skin cancer risk were reported; specific genes were not named

As of May 2023, Amanda had completed surgery and chemotherapy for Stage IIA sigmoid colon cancer and was in close surveillance, with CT scans every 6 months, bloodwork every 3 months, colonoscopy follow-up, and normal cancer-marker bloodwork.

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How I Found Out I had Colon Cancer: I Wrote Off All My Symptoms

Patient Info: Haley P., Female, Under 40 | Stage III

As of March 2023, Haley had completed surgery, CAPOX chemotherapy, and 3 years of daily recurrence-prevention trial pills, with ongoing low-touch trial follow-up and no active recurrence described.

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Recurrent gastric cancer with bone metastases, venous thrombosis and chylothorax

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: bone

Biopsy-confirmed bone recurrence developed more than a year after surgery. He was too unwell for palliative chemotherapy and died a few months after transition to best supportive care.

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Stage IV Colorectal Cancer: Lori's Survivor Story

Patient Info: Lori | Stage IV

Metastatic Site: ovary

After a September 2024 recurrence and surgery in October, Lori said she was in remission and was being monitored with monthly blood work.

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Stage III Colorectal Adenocarcinoma: Mary's Survivor Story

Patient Info: Mary | Stage III

Declared cancer-free in August 2024 after treatment and continuing follow-up.

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Stage III Colorectal Adenocarcinoma: Ashley's Patient Story

Patient Info: Ashley | Stage III

Ashley continues chemotherapy with Xeloda after surgery and 8 rounds of FOLFOX.

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Stage II Gastric Cancer: Sagan's Patient Story

Patient Info: Sagan | Stage II

Sagan reported completing cancer treatment and continued taking medicines for treatment-related symptoms while focusing on recovery.

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Stage IV gastric cancer with liver metastases cleared after chemotherapy, nivolumab and surgery

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: PD-L1-positive, HER2-negative

Metastatic Site: liver

After treatment cleared the gastric and liver lesions, all anticancer therapy was stopped. He remained relapse-free with no evidence of disease for 32 months.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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Stage IV KRAS Colorectal Cancer: Kris's Patient Story

Patient Info: Kris Sokolowski, Male, 40s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: Liver; sternum; spine; lymph nodes; omentum/abdominal…

As of May 2022, Kris was living with Stage IV KRAS G13D-mutant colorectal cancer. Most tumors had been stable or shrinking, but abdominal/omental disease continued to grow despite additional full-strength chemotherapy, so clinical-trial and immunotherapy options were being explored.

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Colon Cancer Returned in a Mesenteric Lymph Node 2 Years After Surgery

Patient Info: Anonymized, Male

The recurrent disease was removed with negative margins in a curative-intent operation. At 8 months, his weight was stable and his energy was improving.

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Metastatic hepatoid gastric adenocarcinoma achieving complete remission with sintilimab

Patient Info: Anonymized, male | Stage IV

Biomarkers: AFP markedly elevated

Metastatic Site: liver

By the fifth sintilimab cycle, gastroscopy showed no gastric tumor, CT showed no liver metastases and AFP had normalized; complete remission was confirmed and remained stable during subsequent treatment.

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HER2-positive metastatic gastric cancer responding to trastuzumab deruxtecan rechallenge

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver

After trastuzumab deruxtecan was restarted, his symptoms improved after the first cycle and imaging showed tumor shrinkage after 3 cycles. He was still receiving treatment without progression at the latest follow-up.

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Stage II Colorectal Adenocarcinoma: Gordon's Survivor Story

Patient Info: Gordon | Stage II

Gordon was declared cancer-free in September 2022 after surgery and chemotherapy.

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A second colon cancer leading to a Lynch syndrome diagnosis

Patient Info: Anonymized, Male, 40s

Biomarkers: Complete loss of MSH2 and MSH6 nuclear staining in the cecal tumor; germline pathogenic MSH2 variant NM_000251.2:c.942+3A>T; Lynch syndrome.

The cecal cancer was treated with complete colectomy, while later presumed recurrences were ultimately identified as meningiomas and metastatic pheochromocytoma; he died after the pheochromocytoma progressed.

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