Stage IB pancreatic adenocarcinoma with lung and pleural recurrence: long-term disease control on chemotherapy

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: Metastatic pancreatic cancer in lung: CK19/MUC1/CA19-9-positive, TTF-1-negative. UGT1A1 *6 heterozygous; no actionable mutation found.

Metastatic Site: lung, pleura

As of April 2025, he remained alive on chemotherapy 6 years and 8 months after initial pancreatic surgery and 4 years and 7 months after pulmonary oligometastatic recurrence, with no new lesions and stable disease on imaging.

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Stage III Colorectal Cancer: Ian's Survivor Story

Patient Info: Ian, Male, Under 40 | Stage III

Ian had Stage III sigmoid colon cancer treated with robotic laparoscopic surgery and adjuvant FOLFOX-based chemotherapy. As of July 2025, he described negative ctDNA tests and clear scans, with his oncologist comfortable saying he had been NED since surgery on December 13, 2022.

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Stage 4 colorectal cancer: complete response with panitumumab and FOLFOX4

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF wild type; MSS/pMMR; HER2 not overexpressed. CEA and CA19-9 were elevated.

Metastatic Site: periaortic and pelvic lymph nodes; left ovary/adnexa

As of November 2024, she was alive and continuing second-line FOLFIRI with stable disease after prior complete remission on panitumumab plus FOLFOX4 and later progression with ovarian metastasis.

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Metastatic colon cancer: soft-tissue and adrenal metastases responding to FOLFIRI plus bevacizumab

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type. CK20 and Ki-67 supported colorectal metastasis; CEA/CA19-9 were elevated.

Metastatic Site: lungs; left arm/biceps soft tissue; right…

As of May 2025, metastatic colon cancer involving soft tissue, muscle, lung history, and right adrenal gland had regressed after 12 months of FOLFIRI plus bevacizumab, and the patient was alive 1 year after chemotherapy completion.

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MSI-H locally advanced right colon cancer: pathologic complete response after oxaliplatin, capecitabine, and immunotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: MSI-H on tumor gene testing

After oxaliplatin, capecitabine, and sindilizumab conversion therapy followed by laparoscopic radical right hemicolectomy, postoperative pathology showed no viable tumor cells and tumor regression grade 0 complete response.

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NRG1-Fusion Colorectal Cancer Progressing on Afatinib

Patient Info: Anonymized, female, 70+

Biomarkers: CD74-NRG1 fusion; no KRAS alteration detected

The cancer progressed clinically after 8 weeks on afatinib. She died in November 2021.

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How I Found Out I Had Stage 4 Colon Cancer!

Patient Info: Rachael Marie, Female, Under 40 | Stage IV

Metastatic Site: ovaries, liver

Rachael completed 12 cycles of FOLFOX/oxaliplatin; colonoscopy looked clear, liver lesions had shrunk, and no new lesions were reported, with further surgical planning pending.

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Stage IV cecum cancer with liver and ovarian metastases: ramucirumab-related nephrotic syndrome and glomerular microangiopathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Cancer biomarkers were not reported. Kidney injury workup showed severe protein leakage and biopsy-proven glomerular microangiopathy.

Metastatic Site: liver, right ovary

The liver metastasis shrank after XELOX plus bevacizumab and metastatic liver/ovarian sites were resected, but ramucirumab-based second-line therapy was stopped after nephrotic syndrome and severe glomerular microangiopathy; blood pressure and proteinuria improved with telmisartan.

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Stage IV Colorectal Adenocarcinoma: Lindy's Patient Story

Patient Info: Lindy Avalos, Female, Under 40 | Stage IV

Metastatic Site: lymph nodes, liver, lungs

As of December 2024, Lindy was on maintenance chemotherapy after 6 months of oxaliplatin and said she had been responding fairly well, though she was still living with Stage IV disease.

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Colon cancer recurring in the spleen with a serious splenic abscess

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: KRAS wild-type, NRAS wild-type, BRAF wild-type

Metastatic Site: spleen

More than 5 years after his 2016 colectomy, he was treated for metastatic recurrence. Disease was assessed as stable during systemic therapy, and he later recovered well after splenectomy for confirmed splenic metastasis.

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Stage III Colorectal Cancer: Jose's Survivor Story

Patient Info: Jose Santos, Male, 40s | Stage III

As of December 2024, more than 2 years after surgery for Stage III colorectal cancer, Jose had no evidence of disease, had adapted well to his ileostomy, and no longer had ulcerative colitis symptoms.

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Stage IV KRAS Colorectal Cancer: Lauren's Patient Story

Patient Info: Lauren Bimage, Female, Under 40 | Stage IV

Biomarkers: Patient-reported KRAS-mutated colon cancer

Metastatic Site: chest; abdominal/peritoneal lining; spine/back

As of September 2024, Lauren was living with both Stage IV breast cancer and Stage IV colon cancer. Colon cancer markers were described as low/normal, while biopsy showed the persistent back/spine disease was breast cancer.

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Stephanie’s Stage 3 Colon Cancer Story

Patient Info: Stephanie, Female, Under 40 | Stage III

CT and PET imaging after treatment showed no active colon cancer. Her October 2023 scans were clear and her oncologist described the cancer as in remission; unchanged spots in the liver and lung continued to be monitored.

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Stage IV Colorectal Adenocarcinoma: Nick's Patient Story

Patient Info: Nick Sprague, Male, 40s | Stage IV

Metastatic Site: distant lymph nodes in abdomen/near aorta and left…

As of July 2024, Nick was living with Stage IVA colon cancer and receiving Keytruda/pembrolizumab with fewer side effects than chemotherapy; no NED status had been reached.

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Stage IV Colorectal Adenocarcinoma: Elizabeth's Survivor Story

Patient Info: Elizabeth Wachsberg, Female | Stage IV

Metastatic Site: liver

As of July 2024, Elizabeth was 5 years cancer-free after Stage IV colon cancer with liver metastases, chemotherapy, and surgery.

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Stage IV BRAF Colorectal Cancer: Sophie's Survivor Story

Patient Info: Sophie, Female | Stage IV

Biomarkers: BRAF-mutated; MSI / microsatellite instability

Metastatic Site: liver; lymph nodes including neck

As of June 2024, Sophie had been off treatment for nearly 3 years and described herself as currently cancer-free after surgery, chemotherapy, immunotherapy, and liver surgery showing no cancer cells.

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Stage IV Colorectal Cancer: Amy's Patient Story

Patient Info: Amy Nicole, Female, Under 40 | Stage IV

Metastatic Site: liver; lymph nodes near kidneys/retroperitoneal lymph…

As of June 2024, Amy was living with recurrent Stage IV colon cancer and was on an immunotherapy clinical trial that improved quality of life compared with chemotherapy, though she did not describe remission or NED.

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Stage II Colorectal Cancer: Savannah's Survivor Story

Patient Info: Savannah Kaspar, Female, Under 40 | Stage II

Biomarkers: Lynch syndrome genetic testing negative

As of March 2024, Savannah had completed partial colectomy and 4 rounds of adjuvant chemotherapy for Stage II sigmoid colon cancer and had entered surveillance with bloodwork every 3 months.

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How I KNEW I Had COLON CANCER

Patient Info: Courtney, Female | Stage III

As of March 2024, Courtney was nearly 3 years in remission after surgery and adjuvant chemotherapy for Stage IIIA colorectal cancer, with follow-up every 6 months.

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Stage IIIB to metastatic rectal cancer: setback and treatment journey

Patient Info: Justine, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

As of March 2024, Justine was living with metastatic rectal cancer involving liver and lung, described as treatable but not curable, after surgery, permanent ileostomy, IV chemotherapy, liver ablation, lung SBRT, and Y-90 liver radioembolization.

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Stage IV Colorectal Cancer: Jim's Patient Story

Patient Info: Jim Bromwich, Male, Under 40 | Stage IV

Metastatic Site: Lung

As of January 2024, he had completed focused radiation to an isolated lung nodule and was awaiting follow-up scans; another tiny lung nodule was being monitored but was not PET-avid.

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Metastatic gastric cancer with an ATM mutation responding to olaparib

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: Pathogenic germline ATM mutation, HER2-negative, PD-L1 15%

Metastatic Site: peritoneum

He had a deep response lasting about 18 months, but imaging in December 2023 again showed peritoneal carcinomatosis.

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Colorectal cancer: using a blood test (ctDNA) to guide immunotherapy after surgery — Case 1

Patient Info: Anonymized, Male, 50s

Biomarkers: KRAS ; TMB 11 mutations/Mb; loss of MLH1 and PMS2; dMMR/MSI-H; germline multigene panel negative; ctDNA positive after surgery and chemotherapy

Pembrolizumab cleared ctDNA within about 3 months. After completing 1 year of immunotherapy, surveillance CT showed no evidence of disease and ctDNA remained negative.

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Stage III Colorectal Adenocarcinoma: Marissa's Patient Story

Patient Info: Marissa | Stage III

Still in active treatment at the time of the story after surgery and chemotherapy, with 15 radiation sessions delivered in September 2025.

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