Stage 1 invasive ductal breast cancer: nipple-preserving mastectomy with reconstruction

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER-positive; PR-positive; HER2-negative; Ki-67 28%

No signs of recurrence 20 months after nipple-preserving mastectomy, sentinel node biopsy, immediate reconstruction, adjuvant chemotherapy, and endocrine therapy for ER-positive, PR-positive, HER2-negative invasive ductal breast cancer.

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Stage IV KRAS Colorectal Cancer: Lauren's Patient Story

Patient Info: Lauren Bimage, Female, Under 40 | Stage IV

Biomarkers: Patient-reported KRAS-mutated colon cancer

Metastatic Site: chest; abdominal/peritoneal lining; spine/back

As of September 2024, Lauren was living with both Stage IV breast cancer and Stage IV colon cancer. Colon cancer markers were described as low/normal, while biopsy showed the persistent back/spine disease was breast cancer.

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Stage 4 breast cancer: ongoing treatment with multi-line chemotherapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Initial tumor: hormone receptor-negative; HER2 2+. 2011 recurrence: ER 10%; PR 70%; HER2 2+.

Metastatic Site: pleura/pleural effusion; lung

Metastatic breast cancer with malignant pleural effusion achieved complete response after chemotherapy and long-term endocrine therapy; PET-CT in October 2023 still showed complete response, with ongoing cardiac and bone-health management.

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Rare Triple-Negative Mucinous Cystadenocarcinoma of the Breast

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative

At 6-month follow-up after treatment, she was alive and well.

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ER-positive breast cancer: mastectomy after hormone therapy

Patient Info: Anonymized, Female, 50s | Stage II

Biomarkers: Breast cancer was ER+ and HER2-low/negative. PR changed from positive on biopsy to negative on final pathology; HNA-1 antibody found for neutropenia.

Stage IIA ER-positive invasive ductal breast cancer had no recurrence 3 years after endocrine therapy and total mastectomy with sentinel lymph node biopsy; autoimmune neutropenia was monitored rather than directly treated.

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Triple-negative breast cancer: partial response to TAC chemotherapy

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: Triple-negative breast cancer with EGFR positivity and high Ki-67; BRCA1 staining was positive by IHC.

After 1 cycle of TAC chemotherapy, the large ulcerated breast tumor shrank enough for surgery. Radical mastectomy with adjacent flap transfer achieved clear margins and no nodal metastatic cancer; she was recovering at home while awaiting planned postoperative AC-T chemotherapy.

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Inflammatory Breast Cancer: Shirley's Patient Story

Patient Info: Shirley Joseph

Shirley completed chemotherapy and a July 2024 mastectomy, with radiation and hormonal therapy still planned.

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Breast Cancer: Krista's Patient Story

Patient Info: Krista Brown, Female

Biomarkers: Pathogenic ATM mutation; hormone receptor-positive; HER2-negative; Oncotype DX score 1/100

As of August 2024, Krista had completed mastectomy/reconstruction surgery and was continuing adjuvant tamoxifen with low reported recurrence risk.

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Triple-negative breast cancer: partial response to immunotherapy combination

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Initial tumor: ER-negative; PR-negative; HER2-negative; Ki-67 >80%

Metastatic Site: left lung, neck lymph nodes, mediastinal lymph nodes

Metastatic triple-negative breast cancer had a partial response after 9 months of pembrolizumab plus MK-4830, with reduced tumor burden, decreased lung and mediastinal metastases, and no new metastatic lesions; immunotherapy continued after prednisone controlled a grade 2 lichenoid eruption.

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Triple-Negative Pleomorphic Lobular Breast Cancer in a BRCA1 Carrier

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative, BRCA1 pathogenic mutation

Surgery after neoadjuvant treatment showed a complete pathologic response with no cancer in the 2 sampled sentinel lymph nodes.

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Right-Sided Ductal Carcinoma in Situ Before a Second Breast Cancer

Patient Info: Anonymized, female, 60s

Biomarkers: ER-positive; PR-positive; HER2 1+

A woman treated for right-sided ductal carcinoma in situ in 2018 later developed a separate invasive cancer in the opposite breast.

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HER2-Positive Breast Cancer That Spread to the Cervix

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: HER2-positive; ER and PR less than 1% in the left breast tumor

Metastatic Site: cervix, esophagus, mediastinal lymph nodes

Cervical metastasis showed a local complete response after brachytherapy, but systemic disease later progressed to the esophagus. She died after 4 months of nutritional support and palliative treatment.

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Stage 0 DCIS breast cancer: disease-free after treatment

Patient Info: Erica, Female | Stage 0

Biomarkers: BRCA-negative

As of August 2024, Erica described herself as cancer-free after Stage 0 DCIS treated with double mastectomy and reconstruction, with peace of mind about recurrence risk.

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Stage 3 infiltrating ductal carcinoma treated with radical mastectomy

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: Breast cancer was ER/PR positive, HER2 negative

The patient recovered fully after right radical mastectomy and complete axillary dissection for Stage III male breast infiltrating ductal carcinoma; adjuvant therapy and recurrence follow-up were not reported in the extracted case text.

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Stage 4 invasive ductal carcinoma: metastatic disease with bone involvement managed successfully

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER <1%; PR 0%; HER2 score 3+; Ki-67 60%

Metastatic Site: bone (12th thoracic vertebra/T12)

Stage IV HER2-positive breast cancer had improved T12 bone metastasis, major breast-tumor regression on trastuzumab deruxtecan, and pathologic complete response in the breast after mastectomy; durable systemic disease status was not reported.

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Breast cancer history with painful implant capsule: no recurrence or BIA-ALCL found

Patient Info: Anonymized, Female, 40s

Biomarkers: Implant/capsule pathology showed necrotic tissue only; no tumor cells, CD30 signal, bacteria

The painful implant/capsule episode did not show breast cancer recurrence or BIA-ALCL on pathology; symptoms and cancer concern improved after implant removal, while oral flumatinib maintenance for acute B-lymphoblastic leukemia continued.

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Low-Grade Adenosquamous Breast Cancer With High-Grade Transformation

Patient Info: Anonymized, female, 50s

Biomarkers: Focal ER-positive; PR-negative; HER2-negative; EGFR-positive

No tumor recurrence or metastasis was observed during follow-up after surgery and chemotherapy.

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Stage I Invasive Lobular Carcinoma: Jessica's Patient Story

Patient Info: Jessica, Female, 40s | Stage I

Biomarkers: Myriad genetic testing negative; Oncotype DX score 19; RSClin recurrence risk 19%; isolated tumor cells around 1 sentinel lymph node without invasion

As of July 2024, Jessica had completed bilateral mastectomy for Stage IB ILC and was moving forward with radiation and long-term hormone suppression after chemotherapy was not recommended.

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Rare acinic cell breast cancer treated with mastectomy

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative; pMMR/MSS; Ki-67 very high. TP53 and several other mutations reported; no gene fusion/rearrangement found.

Alive for 43 months with no metastasis or recurrence after surgery, 8 cycles of epirubicin/cyclophosphamide, and radiotherapy for breast acinic cell carcinoma with high-grade solid transformation.

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Stage IV Breast Cancer: Samantha's Patient Story

Patient Info: Samantha, Female, Under 40 | Stage IV

Biomarkers: Hormone-positive breast cancer; specific receptor details not reported

Metastatic Site: bone: rib, spine, pelvis

As of July 2024, Samantha was living with Stage IV hormone-positive breast cancer with bone metastases. Current treatment was working in most areas, but a breast tumor continued to grow and was surgically removed; ongoing treatment and 3-month scans were reported.

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Finding A Lump To BREAST CANCER!

Patient Info: Kelsey Harrison, Female, Under 40 | Stage II

Biomarkers: ER-positive

As of July 2024, Kelsey had completed chemotherapy, double mastectomy with axillary lymph-node removal, and radiation, and was continuing tamoxifen plus Lupron ovarian suppression with additional planned systemic therapy.

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HR-Positive Breast Cancer: LaShae's Patient Story

Patient Info: LaShae, Female, Under 40

Biomarkers: ER-positive; MammaPrint high-risk recurrence; 70-gene hereditary cancer panel negative

As of June 2024, LaShae had completed mastectomy and was undergoing TC chemotherapy, with radiation and long-term hormonal therapy planned; no remission or NED status was stated.

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Stage II Invasive Lobular Carcinoma: Lizzie's Survivor Story

Patient Info: Lizzie, Female | Stage II

Lizzie completed mastectomy, reconstruction-related surgery and 5 weeks of radiation. She remained on a planned 10-year course of an aromatase inhibitor and became active in breast cancer research advocacy.

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Stage IV triple-negative breast cancer in remission: CBD and exercise for neuropathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Triple-negative breast cancer. Blood and immune inflammation measures were tracked during neuropathy care.

Metastatic Site: liver

She was in remission for more than 5 years after Stage IV breast cancer with a solitary liver metastasis, while later managing chemotherapy-induced peripheral neuropathy with CBD and an exercise program that improved symptoms and function.

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