Low-Grade Adenosquamous Breast Cancer With High-Grade Transformation

This breast cancer diagnosis at a glance

Biomarkers
Focal ER-positive; PR-negative; HER2-negative; EGFR-positive
Sex
female
Treatment
surgery and chemotherapy
Outcome
Cancer-Free / NED

Treatment course, step by step

  1. Underwent excision of both breast masses, followed by simple right mastectomy with sentinel lymph node biopsy after the right-sided cancer was confirmed.
  2. Received docetaxel and cyclophosphamide for 4 months.

What happened, in summary

A 57-year-old woman was found to have masses in both breasts during a routine examination. Imaging raised greater concern for the right-sided lesion. Both masses were removed for diagnosis. The left lesion was benign fibrocystic disease, while the right breast contained a rare low-grade adenosquamous carcinoma with areas of high-grade transformation.

The cancer was small, about 0.8 cm, and sentinel lymph nodes were negative. Testing showed focal estrogen-receptor expression, with progesterone receptor and HER2 negative. The tumor also showed EGFR positivity.

After the diagnosis, she underwent a simple right mastectomy with sentinel lymph node biopsy. She then received docetaxel and cyclophosphamide for 4 months and did not report significant discomfort during chemotherapy. During the documented follow-up period, there was no evidence of local recurrence or metastatic spread.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer

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