Cancer Stories
Lung CancerROS1-Positive Stage III Pulmonary Sarcomatoid Carcinoma With Complete Pathologic Response
Patient Info: Anonymized, male, 60s | Stage III
Biomarkers: ROS1 rearrangement; TP53 mutation; PD-L1 TPS 0%
Lung CancerStage III Pulmonary Sarcomatoid Carcinoma With Major Response to Neoadjuvant Treatment
Patient Info: Anonymized, male, 50s | Stage III
Biomarkers: PIK3CA mutation; TP53 mutation; PD-L1 TPS 5%
Lung CancerStage III Pulmonary Sarcomatoid Carcinoma With Major Response and No Recurrence
Patient Info: Anonymized, male, 50s | Stage III
Biomarkers: NRAS mutation; TP53 mutation; PD-L1 TPS 60%
Lung CancerStage III Pulmonary Sarcomatoid Carcinoma Treated With Neoadjuvant Immunochemotherapy and Surgery
Patient Info: Anonymized, male, 60s | Stage III
Biomarkers: TP53 mutation; PD-L1 TPS 40%
Lung CancerStage 3C lung cancer: complete remission on immunotherapy and chemotherapy
Patient Info: Anonymized, Male, 40s | Stage III
Biomarkers: EGFR wild-type; ALK rearrangement not detected; PD-L1 <1%
Lung CancerStage 4 lung LCNEC: major response to chemotherapy plus immunotherapy
Patient Info: Anonymized, Male, 40s | Stage IV
Biomarkers: Large-cell neuroendocrine lung cancer markers were positive. PD-L1 was negative
Metastatic Site: left adrenal gland
Lung CancerPrimary Lung Cancer That Spread to Both Breasts and the Adrenal Gland
Patient Info: Anonymized, Female, 60s | Stage IV
Biomarkers: PD-L1 negative; EGFR, ALK, ROS1, RET, MET exon 14, NTRK and BRAF wild type
Metastatic Site: both breasts, subcutaneous tissue, adrenal gland
Lung CancerStage II Lung Cancer: Att's Patient Story
Patient Info: Att Callahan, Female, 70+ | Stage II
Lung CancerStage 4 lung cancer: complete response to chemo-immunotherapy combo
Patient Info: Anonymized, Male, 40s | Stage IV
Metastatic Site: right hilar lymph nodes, mediastinal lymph nodes
Lung CancerFirst reported case of a severe immune reaction (cytokine release syndrome) from tislelizumab
Patient Info: Anonymized, Male, 70+ | Stage IV
Metastatic Site: pleura (malignant pleural effusion)
Lung CancerLung cancer immunotherapy causing sudden heart inflammation and type 1 diabetes
Patient Info: Anonymized, Female | Stage III
Lung CancerSevere kidney inflammation after pembrolizumab for lung adenocarcinoma
Patient Info: Anonymized, Male, 60s
Lung CancerAfatinib-related kidney injury during treatment for EGFR-positive metastatic lung cancer
Patient Info: Anonymized, Male, 50s | Stage IV
Biomarkers: EGFR-positive.
Metastatic Site: pleura
Lung CancerEarly kidney injury after first-line treatment for lung adenocarcinoma
Patient Info: Anonymized, Male, 70+
Lung CancerECMO-Supported Airway Tumor Removal in Stage IIB Lung Cancer
Patient Info: Anonymized, Male, 50s | Stage II
Lung CancerImmunotherapy and surgery for adenosquamous lung cancer with brain metastases
Patient Info: Anonymized, Female, 70+
Biomarkers: PD-L1 positive; no actionable mutations on next-generation sequencing.
Lung CancerStrong Response to Pembrolizumab-Based Therapy for Pleomorphic Lung Cancer
Patient Info: Anonymized, Male, 60s | Stage III
Biomarkers: EGFR-negative; ALK-negative; ROS1-negative; PD-L1 TPS 90%-100%.
Lung CancerPembrolizumab Controlled Metastatic Pleomorphic Lung Cancer After Chemotherapy Failed
Patient Info: Anonymized, Male, 40s | Stage IV
Biomarkers: EGFR-negative; ALK-negative; ROS1-negative; BRAF-negative; PD-L1 TPS 60%-70%; BRCA2, and TP53 mutations; tumor mutation burden 42 mutations/Mb; no actionable alteration.
Metastatic Site: right adrenal gland; left adrenal gland; bone
Lung CancerLung Cancer Metastases to Both Kidneys Causing Kidney Failure
Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced
Biomarkers: PD-L1 highly expressed
Metastatic Site: brain|bilateral kidneys|lungs
Lung CancerLow-dose intrapleural therapy relieved a complex malignant pleural effusion
Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced
Biomarkers: EGFR mutation-negative; ALK alteration-negative; ROS1 alteration-negative.
Metastatic Site: pleura; adrenal gland; bone
Lung CancerRecurrent Mucinous Lung Cancer With Dose-Dependent Afatinib Responses
Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced
Biomarkers: SDC4-NRG1 fusion; PD-L1 not expressed; low tumor mutation burden
Metastatic Site: bilateral lungs
Lung CancerBlood Vessel Inflammation After Durvalumab Treatment for Stage III Lung Cancer
Patient Info: Anonymized, Female, 70+ | Stage III
Lung CancerPleomorphic lung cancer responding to pembrolizumab plus chemotherapy
Patient Info: Anonymized, Male, 60s | Stage IV
Biomarkers: PD-L1 tumor proportion score >75%; EGFR negative; ROS1 negative; ALK fusion negative
Metastatic Site: right 8th rib, left adrenal gland
Multifocal stage IIIA lung adenocarcinoma responding to nivolumab
Patient Info: Anonymized, Female, 60s | Stage III
Biomarkers: CK7-positive; TTF-1-positive; napsin-A-positive; PD-L1 85% positive.