Stage III Pulmonary Sarcomatoid Carcinoma Treated With Neoadjuvant Immunochemotherapy and Surgery
This lung cancer diagnosis at a glance
- Stage at diagnosis
- Stage III
- Biomarkers
- TP53 mutation; PD-L1 TPS 40%
- Sex
- male
- Treatment
- chemotherapy, immunotherapy and surgery
- Outcome
- Cancer-Free / NED
Treatment course, step by step
- Received 2 cycles of sintilimab with albumin-bound paclitaxel and cisplatin, producing a partial response.
- Underwent right lower lobectomy with systematic lymph-node dissection and had about 30% residual tumor.
- Received 2 cycles of postoperative immunotherapy plus platinum-based chemotherapy.
What happened, in summary
A 65-year-old man developed cough and coughing up blood and was evaluated in March 2022. CT showed a right lower-lung tumor obstructing the lower-lobe bronchus together with an enlarged mediastinal lymph node. Biopsy showed a malignant spindle-cell tumor consistent with pulmonary sarcomatoid carcinoma, classified as Stage III.
Tumor testing found a TP53 mutation, and PD-L1 expression was 40%. He received 2 cycles of sintilimab combined with albumin-bound paclitaxel and cisplatin. Follow-up imaging showed that the lung mass and mediastinal node had shrunk substantially, representing a partial response.
In June 2022, he underwent right lower lobectomy with systematic lymph-node dissection. Pathology showed residual pulmonary sarcomatoid carcinoma involving about 30% of the treated tumor area. Several sampled nodes were negative, although cancer remained in station 7 nodes.
He received 2 more cycles of immunotherapy plus platinum-based chemotherapy after surgery. During postoperative follow-up, no recurrence was detected for more than 30 months.
Where this story comes from
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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Collections this story belongs to
- Stage 3 Lung Cancer 77 stories
- TP53 Mutation Lung Cancer 19 stories
- Chemotherapy for Lung Cancer 386 stories
These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer