Treatment-Refractory Triple-Negative Breast Cancer Treated With Tumor-Infiltrating Lymphocytes

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: Germline BRCA1 pathogenic variant; later triple-negative phenotype

Metastatic Site: skin, lungs, bones

Tumor burden briefly decreased after tumor-infiltrating lymphocyte therapy, but she developed severe treatment complications followed by rapid cancer relapse and died about 1 month after the TIL/IL-2 treatment began.

PubMed CentralRead more →

Large Malignant Phyllodes Tumor Removed With Mastectomy

Patient Info: Anonymized, female, 70+

At 18 months of follow-up, imaging showed no suspicious lung lesions, lymph-node enlargement, or other evidence of recurrence or metastasis.

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Right-Breast DCIS Found Alongside a Separate Malignant Phyllodes Tumor

Patient Info: Anonymized, female, 70+

Biomarkers: ER-positive, PR-positive, HER2-negative

At 18 months of follow-up, there were no documented signs of recurrence or metastasis.

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Breast Cancer Recurs After a 19-Year Remission and Responds to Later Chemotherapy

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Initial tumor: PR-positive, ER-negative, HER2-negative. Recurrence: ER-positive, PR-negative

Metastatic Site: bones

The cancer recurred after a 19-year remission and later spread to bone. More than 21 years after the original diagnosis, she had marked tumor shrinkage, was in good general condition, and had 10 months of progression-free survival after utidelone plus capecitabine.

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Male breast cancer in both breasts linked to Klinefelter syndrome, initially missed

Patient Info: Anonymized, Male | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; Klinefelter syndrome

Metastatic Site: spine / bone

With advanced metastatic disease and an estimated prognosis of weeks or less, care focused on symptom relief under the palliative-care team.

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Adenoid Cystic Breast Cancer Spreads to the Kidney, Lungs, Bone and Spleen

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: Triple-negative

Metastatic Site: kidneys, lungs, spleen, bone, lymph nodes

The cancer progressed from an initial kidney metastasis to widespread disease involving the lungs, spleen, right kidney, lymph nodes, and C4 vertebra. By May 2022 she had worsening cachexia and pain, and best supportive care was recommended.

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Invasive Lobular Carcinoma: Jessica's Patient Story

Patient Info: Jessica, Female

Jessica had completed mastectomy and axillary surgery and had started dose-dense AC chemotherapy. Radiation and 10 years of Tamoxifen were planned as the next treatment steps.

Lobular Breast Cancer AllianceRead more →

Stage III Breast Cancer Linked to Paraneoplastic Neuromyelitis Optica

Patient Info: Anonymized, female, 50s | Stage III

Biomarkers: ER-positive, PR-positive, HER2-negative; tumor AQP4 expression

A 51-year-old woman with Stage III hormone-receptor-positive breast cancer developed a rare paraneoplastic neurologic disorder that caused severe vomiting and spinal-cord symptoms.

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Stage IV Breast Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: BRCA1-negative

Metastatic Site: Bone marrow

As of November 2023, Sherri had no evidence of disease on recent breast cancer scans but remained on targeted treatment every 3 weeks and had started oxaliplatin after surgery for a separate Stage III colon cancer.

The Patient StoryRead more →

Breast cancer lung metastasis treated with a minimally invasive freezing procedure

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; ER-negative

Metastatic Site: lungs

Follow-up PET/CT at 3, 6, 9 and 12 months after cryoablation showed no progression or new lesions without systemic therapy.

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Invasive Lobular Carcinoma: Brenda's Survivor Story

Patient Info: Brenda, Female, 40s

Brenda completed mastectomy, chemotherapy, radiation and an oophorectomy. She remained on anastrozole and a CDK4/6 inhibitor when she shared her story.

Lobular Breast Cancer AllianceRead more →

Stage IV HER2-Positive Inflammatory Breast Cancer: Olivia's Survivor Story

Patient Info: Olivia Franz, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Bones; distant lymph nodes

As of October 2023, Olivia continued to show no evidence of disease on scans while receiving maintenance trastuzumab and pertuzumab every 3 weeks and zoledronic acid every 3 months for bone health.

MD AndersonRead more →

Early-stage breast cancer (DCIS) found unexpectedly within a benign breast lump

Patient Info: Anonymized, Female

At 6 months she was asymptomatic with no palpable breast or axillary masses and entered annual MRI surveillance.

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New Triple-Negative Breast Cancer Develops During Olaparib Treatment for a Separate Lung Cancer

Patient Info: Anonymized, female, 60s

Biomarkers: Triple-negative; germline BRCA2 mutation; BRCA2 reversion mutation

A woman receiving olaparib for BRCA2-mutated metastatic lung cancer developed a separate 14 mm triple-negative breast cancer with a BRCA2 reversion mutation.

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Invasive Lobular Carcinoma: Leigh's Patient Story

Patient Info: Leigh, Female

Leigh died in June 2022 from complications of ovarian cancer. Her lobular breast cancer experience led her to co-found the Lobular Breast Cancer Alliance and build a lasting patient-advocacy legacy.

Lobular Breast Cancer AllianceRead more →

Stage IV Triple-Negative Breast Cancer: April's Patient Story

Patient Info: April Donaldson, Female, 40s | Stage IV

Biomarkers: Triple-negative breast cancer; BRCA1 positive

Metastatic Site: Lungs

As of September 2023, April was living with Stage IV metastatic triple-negative breast cancer in the lungs; scans were stable in February but showed growth again in July, and PARP inhibitor therapy was being planned.

The Patient StoryRead more →

Kelly's Stage 3 Breast Cancer Story: “I’m Still Here & THRIVING!"

Patient Info: Kelly Thomas, Female, Under 40 | Stage III

Biomarkers: Initial triple-negative breast cancer; after surgery

As of August 2023, Kelly was 5 years from her Stage IIIC triple-negative breast cancer diagnosis with no recurrence reported.

The Patient StoryRead more →

Triple-Negative Breast Cancer: Susan's Patient Story

Patient Info: Susan, Female, 70+

Biomarkers: BRCA negative; earlier breast cancer described as triple-negative; later breast cancer estrogen-positive and progesterone-positive; HER2 not reported

As of August 2023, Susan was living after multiple breast cancer diagnoses, including a later estrogen-positive/progesterone-positive non-metastatic breast cancer treated with bilateral mastectomy and ongoing 5-year estrogen-blocker therapy.

The Patient StoryRead more →

HER2-Positive Breast Cancer: Susan's Survivor Story

Patient Info: Susan, Female, 70+

Biomarkers: 2021 breast cancer described as estrogen-positive and progesterone-positive; HER2 not reported. First breast cancer biomarker status not reported.

As of August 2023, Susan was living in survivorship after a first breast cancer treated with lumpectomy, chemotherapy, and radiation and a later separate breast cancer treated with bilateral mastectomy.

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Stage IV Breast Cancer: Britney's Patient Story

Patient Info: Britney Beadle, Female, Under 40 | Stage IV

Metastatic Site: Bone; liver; brain; lungs

As of August 2023, Britney was living with Stage IV breast cancer on Enhertu every 21 days, with liver clear and bone/lung disease showing regression on the latest described scan.

The Patient StoryRead more →

Stage IV Breast Cancer: Brittney's Patient Story

Patient Info: Brittney Beadle, Female, Under 40 | Stage IV

Metastatic Site: Bones; liver; brain; lungs

As of August 2023, Brittney was living with Stage IV breast cancer on ENHERTU every 21 days, with brain clear for 4.5 years, liver clear, and bone and lung disease regressing.

The Patient StoryRead more →

Stage IV Breast Cancer: Fadia's Survivor Story

Patient Info: Fadia, Female, Under 40 | Stage IV

Metastatic Site: Bone | Spleen | Lung | Liver | Brain

As of the August 2023 article update, Fadia had recovered after an initial 3-year breast cancer treatment course and later successful brain tumor surgery following repeated cancer involvement in multiple organs.

HER2-Positive Acantholytic Squamous Breast Cancer Responds Completely to Preoperative Therapy

Patient Info: Anonymized, female

Biomarkers: HER2-positive; postoperative residual in-situ disease ER-positive and PR-positive

The invasive cancer achieved a pathologic complete response, and she had no recurrence or metastasis during 1.5 years of follow-up.

PubMed CentralRead more →

Stage I Triple-Negative Breast Cancer: Melissa's Survivor Story

Patient Info: Melissa Berry, Female, 40s | Stage I

Biomarkers: BRCA mutation reported; triple-negative breast cancer

As of July 2023, Melissa was a 10-year Stage I triple-negative breast cancer survivor with no recurrence reported.

The Patient StoryRead more →