A benign liver granuloma mimicked rectal-cancer recurrence after chemotherapy

Patient Info: Anonymized, Male, 40s

Rectal resection showed a pathologic complete response, and the enlarging liver lesion was repeatedly confirmed as non-malignant granulomatous inflammation rather than metastatic recurrence.

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A second breast cancer arising in a previously known cyst

Patient Info: Anonymized, Female, 70+

Biomarkers: ER >95% positive; PR >95% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

She completed right-breast radiation and was continuing anastrozole 1 mg daily as adjuvant endocrine therapy.

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Small hormone-receptor-positive breast cancer found incidentally on chest CT

Patient Info: Anonymized, Female, 70+

Biomarkers: ER 95% positive; PR 70% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

She was receiving adjuvant breast radiation, with at least 5 years of anastrozole planned afterward.

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Stage III Invasive Ductal Carcinoma: Ximena's Patient Story

Patient Info: Ximena Nardelli, Female, 40s | Stage III

Biomarkers: Hormone receptor-positive

As of February 2020, Ximena had completed mastectomy, 16 chemotherapy sessions, and 21 radiation treatments for Stage III hormone-positive invasive ductal carcinoma and was continuing planned 5-year hormone therapy.

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More than 10 years living with relapsing extensive-stage small cell lung cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Chromogranin-positive.

Metastatic Site: pleura; pancreas; left kidney and perinephric region

After five treatment lines and several metastatic relapses over more than 10 years, his latest irinotecan and carboplatin course produced another partial response and he was doing well at the last follow-up.

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Gastric cancer diagnosed during late pregnancy after severe gastrointestinal bleeding

Patient Info: Anonymized, female, 40s

Biomarkers: HER2-negative

Six months after emergency surgery, chemotherapy and radiation were still ongoing.

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Early breast cancer followed 19 years later by a radiation-related breast sarcoma

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Strongly ER-positive; strongly PR-positive.

The stage IA breast carcinoma remained disease-free for 19 years; a later right-breast mass was a separate radiation-induced sarcoma rather than recurrent carcinoma.

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Small cell lung cancer found through a disabling paraneoplastic neuropathy

Patient Info: Anonymized, Female, 60s

Biomarkers: Anti-CRMP5 antibody-positive.

She completed chemotherapy and radiation and entered oncology follow-up, while the disabling sensory and motor neuropathy persisted and rehabilitation continued.

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Dramatic chemotherapy response in stage IIIB triple-negative breast cancer

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: ER-negative; PR-negative; HER2-negative; BRCA1-negative; BRCA2-negative; germline FLCN c.1285delC associated with Birt-Hogg-Dubé syndrome; tumor TP53 p.T150fs.

Eighteen months after surgery, she had no recurrence following a dramatic chemotherapy response, bilateral mastectomy, chest-wall radiation, and adjuvant capecitabine.

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Stage IV Breast Cancer: Dan's Patient Story

Patient Info: Dan DiNardo, Male, 40s | Stage IV

Metastatic Site: Left femoral ball/hip; spine; lymph nodes; chest

As of January 2020, Dan was living with metastatic recurrent male breast cancer on ongoing hormone-blocking therapy plus a CDK4/6 inhibitor after surgery and hip radiation; his cancer had shown no growth for 1 year.

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Lung Cancer: Keith's Survivor Story

Patient Info: Keith Medovich, Male, 60s

As of January 2020, Keith was rid of lung cancer after 2003 chemotherapy and radiation, but required ongoing management of severe late radiation-related airway stenosis with a custom patient-specific stent.

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Metastatic ER-positive breast cancer complicated by osteonecrosis of the jaw

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: ER-positive.

Metastatic Site: bone (sternum, spine, pelvis, and proximal femur)

After progressive metastatic bone disease and severe medication-related osteonecrosis of the jaw, she entered end-of-life care and died three weeks after discharge to a nursing home.

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N

Patient Info: N | Stage I

Biomarkers: No inherited BRCA variant identified.

N completed lumpectomy and radiation and continued hormone therapy while adjusting to life after treatment.

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Stage II Breast Cancer: Marese's Survivor Story

Patient Info: Marese | Stage II

Marese said the breast cancer was in remission after completing active treatment, and she continued hormone therapy to help maintain remission.

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Ovarian Wilms tumor with early abdominal recurrence

Patient Info: Anonymized, Female, Under 40

Biomarkers: WT1-positive; residual tumor MyoD1-positive

After 3 months of radiation and a further 3 months of chemotherapy, PET showed no FDG-avid malignancy.

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Stage I Breast Cancer: Audrey's Patient Story

Patient Info: Audrey, Female, 60s | Stage I

Audrey completed quadrantectomy and radiation therapy for Stage I breast cancer and remained on hormone therapy, with lymphatic drainage and physical therapy for lymphedema and pain-related effects.

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Breast Cancer: Laura's Survivor Story

Patient Info: Laura

Laura said everything was free of malignant cells and was rebuilding her life and career after treatment.

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Stage II Breast Cancer: Jaidive's Survivor Story

Patient Info: Jaidive, Female, 40s | Stage II

Jaidive was declared cancer-free on 11 November 2021 after lumpectomy, chemotherapy, radiation therapy, and tamoxifen/hormone therapy for Stage II breast cancer, while continuing specialist appointments and medication.

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Stage IV Colorectal Cancer: Lina's Patient Story

Patient Info: Lina | Stage IV

Lina was living with Stage IV colorectal cancer 2–3 years after diagnosis after stopping chemotherapy, radiation, and immunotherapy.

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Stage II Colorectal Cancer: Lina's Survivor Story

Patient Info: Lina | Stage II

Some years after her Stage II colorectal cancer diagnosis, Lina said she was cancer-free.

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Breast Cancer: Serena's Patient Story

Patient Info: Serena

Serena completed surgery and radiation and is currently undergoing hormone therapy.

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Stage II Breast Cancer: Catherine's Survivor Story

Patient Info: Catherine, Female, 50s | Stage II

As of 2020, Catherine had completed lumpectomy, chemotherapy, and radiation therapy for Stage II breast cancer and was in remission, while managing fatigue, hair loss, and peripheral neuropathy.

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Clival skull-base metastasis during treatment for Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: HER2-negative

Metastatic Site: peritoneum, cervical lymph nodes, pelvic bone, lungs,…

At publication he was alive on fourth-line treatment, with no disease progression for 6 months after the clival metastasis was treated and with sustained improvement in his cranial-nerve symptoms.

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Stage IIIA breast cancer treated alongside a synchronous colon cancer

Patient Info: Anonymized, Female, 50s | Stage III

Two years after surgery, she remained well with no CT evidence of metastasis or recurrence while continuing endocrine therapy and six-monthly follow-up.

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