Metastatic Right-Sided Colon Cancer With an NRG1 Fusion

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS mutation; POMK-NRG1 fusion

Metastatic Site: liver|lungs

He had persistent metastatic disease after 16 months of afatinib and entered a phase I trial in January 2020.

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Stage IV Colorectal Adenocarcinoma: Kyle's Survivor Story

Patient Info: Kyle, Under 40 | Stage IV

Kyle was 19 months NED and off treatment after Stage IV colon adenocarcinoma, following about 30 months of chemotherapy and targeted therapy.

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Colon Cancer Survivor: "I Didn't Think I Had Symptoms, Diagnosed Stage 3B" | Shelley's Story

Patient Info: Shelley Brown, Female | Stage III

As of October 2020, Shelley was in remission / no evidence of disease several years after Stage IIIB sigmoid colon cancer treatment, with ongoing surveillance by scans, CEA, and colonoscopy.

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Treatment-Related Inflammation Mimicked Metastatic Colon Cancer Recurrence

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver|peritoneum

Biopsy showed that new lymph-node, liver, and spleen findings were a treatment-related sarcoid-like reaction rather than recurrence, and 18 months of surveillance found no evidence of cancer.

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Colon Cancer Stories: Barbara Majeski

Patient Info: Barbara Majeski, Female, 40s | Stage III

As of May 2020, Barbara was approaching the 5-year mark after Stage III colon cancer, with blood tests every 6 months and annual scans reported as good/clear.

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A benign liver granuloma mimicked rectal-cancer recurrence after chemotherapy

Patient Info: Anonymized, Male, 40s

Rectal resection showed a pathologic complete response, and the enlarging liver lesion was repeatedly confirmed as non-malignant granulomatous inflammation rather than metastatic recurrence.

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An unusual paratesticular metastasis from colon cancer

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: CK20-positive; CDX2-positive; CK7-negative.

Metastatic Site: lungs; right paratesticular soft tissue

He recovered well after removal of the paratesticular metastasis and continued treatment for metastatic colon cancer with his oncology team.

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Gastric cancer with an unexpected appendix metastasis

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: appendix

PET/CT at 6, 12 and 18 months showed no recurrence, giving at least 18 months with no evidence of disease after treatment.

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Colorectal Cancer: Mary's Patient Story

Patient Info: Mary

Within 12 months of the initial treatment course, further tumors were found during follow-up, including one in the liver.

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Metastatic Colon Cancer With KRAS, NRAS, and BRAF Mutations

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS exon 3 ; NRAS exon 2 ; BRAF exon 10 ; PIK3CA exon 2 .

Metastatic Site: liver

The liver metastases progressed despite FOLFOX and bevacizumab, and he died within one year of the initial diagnosis.

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Metastatic Rectal Cancer Complicated by Salmonella-Related Bowel Perforation

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver; lungs

Postoperative infection and wound complications delayed palliative chemotherapy, and he died from metastatic rectal cancer one year later.

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Long-term survival after surgery for colon cancer with a stomach metastasis

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: stomach

She had no signs of recurrence 7 years and 4 months after surgery and was living with good quality of life.

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Colon Cancer and a Separate Liposarcoma Recurring at the Same Time

Patient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced

Metastatic Site: liver|pelvic lymph node

Follow-up imaging showed no evidence of colon cancer after FOLFIRI produced a complete response in the liver and pelvic lymph node. He remained without evidence of disease 1.7 years after recurrence.

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Rectal Signet Ring Cell Cancer With Rapid, Unusual Metastatic Spread

Patient Info: Anonymized, Male, Under 40 | Stage Metastatic/Advanced

Metastatic Site: peritoneum|lumbosacral vertebrae|bone marrow|right…

The cancer recurred 3 months after surgery and spread rapidly to the peritoneum, bones, bone marrow, orbit, and skin. He later entered palliative care.

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Metastatic Colorectal Cancer Treatment Complicated by Severe Lung Inflammation

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: KRAS wild type; NRAS wild type

Metastatic Site: liver

He recovered from the severe treatment-related lung inflammation, was weaned off oxygen within 1 month, and continued oncology follow-up while living with Stage IV colorectal cancer.

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Stage IV Colorectal Cancer: Anatole's Survivor Story

Patient Info: Anatole Karpovs, Male, Under 40 | Stage IV

Metastatic Site: Liver

As of October 2018, Anatole had no evidence of disease after liver surgery and FOLFIRI for a July 2014 liver recurrence, and had been cancer-free for almost 4 years while recognizing that microscopic disease could still be possible.

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Locally advanced transverse colon cancer complicated by a colocutaneous fistula

Patient Info: Anonymized, Female, 60s | Stage III

After initially recovering from surgery, she developed a respiratory infection, sepsis and metabolic encephalopathy and died after cardiorespiratory arrest on postoperative day 12.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: peritoneum

Developed peritoneal recurrence 3 months after postoperative chemotherapy and was receiving second-line chemotherapy at follow-up.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, gastrectomy and HIPEC

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: peritoneum

At follow-up, he had no signs of recurrence.

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Severe but reversible neurologic side effects during 5-fluorouracil treatment for Stage IV colorectal cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver

His confusion, dysarthria and ataxia resolved within 24 hours with intravenous hydration, and the MRI lesion resolved within 1 month. The cancer later progressed on restaging, prompting another treatment change.

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Stage III Colon Cancer Found Alongside Ovarian and Adrenal Cancers

Patient Info: Anonymized, female, 40s | Stage III

More than 2 years after diagnosis, she had no sites of recurrence or metastatic disease, and a recent colonoscopy showed no recurrence or polyps.

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Metastatic Colon Cancer With Tumor Thrombus Extending Into the Right Atrium

Patient Info: Anonymized, female, 40s

Biomarkers: BRAF wild-type, KRAS wild-type, NRAS wild-type

Her metastatic colorectal cancer progressed despite multiple treatment lines. Supportive care alone was chosen after her performance status deteriorated, and she later died from multiorgan failure in the setting of metastatic cancer.

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Stage III Rectal Cancer Among Five Synchronous Gastrointestinal Cancers

Patient Info: Anonymized, male, 50s | Stage III

Six years after surgery and adjuvant treatment, he remained without recurrence or metastasis and continued regular follow-up.

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Stage IV Colorectal Cancer: Dawn's Survivor Story

Patient Info: Dawn Eicher, Female, Under 40 | Stage IV

Metastatic Site: liver

After treatment for Stage IV colorectal cancer and a later recurrence, Dawn had 2 consecutive scans showing no evidence of disease and had been cancer-free for 8 months.

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