Osimertinib Improved Spinal Cord Metastases in Long-Standing Lung Cancer

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: Initial surgical specimen: no detected EGFR mutation and ALK-negative. Later pleural-fluid tumor: acquired EGFR T790M mutation with no other detected EGFR mutation.

Metastatic Site: cervical and mediastinal lymph nodes; bone; brain;…

Osimertinib improved neurologic function and kept the lung cancer stable for 14 months; he later died from bacterial pneumonia.

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Stage IV gastric cancer complicated by paraneoplastic dermatomyositis during nivolumab treatment

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: liver, lung, abdominal cavity

He died from rapidly worsening gastric cancer 142 days after the first nivolumab dose, roughly 14 months after his April 2017 diagnosis.

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Mixed adenocarcinoma-neuroendocrine gastric cancer progressing after multiple treatments

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver

After progression through several treatments and development of liver metastasis, he was taking apatinib at the latest update.

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Small Cell Lung Cancer With SIADH in a 45-Year-Old Man Receiving Chemotherapy

Patient Info: Anonymized, male, 40s

After brain and pelvic metastases developed through successive chemotherapy lines, care shifted to a palliative approach and he died approximately 1 year after diagnosis.

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Mucinous gastric cancer presenting with an iris metastasis

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: iris, peritoneum, para-aortic and mesenteric lymph…

She died of aspiration pneumonia 8 months after presentation. Autopsy confirmed persistent invasive gastric cancer with metastatic spread.

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Metastatic Lung Adenocarcinoma Complicated by Severe Nivolumab Pneumonitis

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Microsatellite stable; low tumor mutation burden; PD-L1 70%

His severe nivolumab-related pneumonitis improved after infliximab.

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Hereditary diffuse gastric cancer in a 34-year-old man with a CDH1 mutation

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: CDH1 monoallelic deletion of exons 1-2

Under surveillance with the most recent CT showing no active disease and no evidence of disease at the latest follow-up.

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Stage IV gastric cancer with peritoneal metastases responds to combined chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, Under 40 | Stage IV

Metastatic Site: peritoneum

At last follow-up in January 2018, she was asymptomatic and examinations showed no evidence of disease.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: peritoneum

Developed peritoneal recurrence 3 months after postoperative chemotherapy and was receiving second-line chemotherapy at follow-up.

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Stage IV gastric adenocarcinoma progresses despite multiple chemotherapy approaches for peritoneal metastases

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: peritoneum

The cancer progressed during second-line treatment, and he died from tumor-related complications in April 2017, about 16 months after his December 2015 admission.

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Stage II Ovarian Cancer: Betsy's Patient Story

Patient Info: Betsy Feldmann, 50s | Stage II

After treatment ended, Betsy returned to endurance events, including triathlon competition, long-distance cycling, and open-water swimming.

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ERBB2-Mutated Stage III Lung Cancer With Liver Recurrence and Multiple Lines of Therapy

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ERBB2 exon 20 insertion

Metastatic Site: liver

After 6 months of disease control on vinorelbine plus trastuzumab, the cancer progressed in all sites and she chose hospice care.

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ERBB2-Mutated Metastatic Lung Adenocarcinoma With Progression Across Multiple Regimens

Patient Info: Anonymized, male

Biomarkers: ERBB2 V777delinsVGSP mutation

After a brief period of stable disease on cisplatin plus docetaxel, the cancer progressed through erlotinib, gemcitabine and afatinib.

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ERBB2-Mutated Metastatic Lung Adenocarcinoma With Limited Disease Control Across Multiple Therapies

Patient Info: Anonymized, female

Biomarkers: ERBB2 V776delinsVC mutation

After temporary stable disease when bevacizumab was added to chemotherapy, the cancer progressed on trastuzumab plus paclitaxel and then erlotinib.

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Recurrent Gastric Cancer With Peritoneal Spread and Acute Hypertension During Ramucirumab

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: peritoneum

Treatment was stopped after 2 cycles because of progression, no further cytotoxic treatment was started, and he died at home 19 weeks after the last chemotherapy.

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Stage I Ovarian Sertoli-Leydig Cell Tumor in a 19-Year-Old

Patient Info: Anonymized, female, Under 40 | Stage I

She was continuing adjuvant chemotherapy 4 months into treatment without major reported complications.

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Mixed Ovarian Germ Cell Cancer in an 18-Year-Old

Patient Info: Anonymized, female, Under 40

At both 3-month and 6-month follow-up, she had no evidence of recurrence.

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Gastric cancer recurs in the spermatic cord 7 years after treatment

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: epididymis, spermatic cord

At 26 months after orchiectomy, he was doing well with no evidence of recurrence, more than 9 years after his original gastric-cancer surgery.

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Gastric cancer recurs in the spermatic cord after 6 years without recurrence

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: spermatic cord

At 20 months after orchiectomy, he was stable with no recurrence, more than 7 years after treatment of his original gastric cancer.

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Gastric adenocarcinoma recurs in the adrenal gland 6 years after gastrectomy

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: left adrenal gland

At 13 months after resection of the adrenal metastasis, imaging and tumor-marker follow-up found no evidence of recurrence, placing him more than 7 years beyond the original gastrectomy.

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Signet-ring gastric cancer with repeated recurrences and a late adrenal metastasis

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: left adrenal gland

At 12 months after resection of the adrenal metastasis, no definite recurrence was found, roughly 7 years after the original gastric-cancer surgery.

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Synchronous Stage IA breast cancer and Stage IIA lung adenocarcinoma: disease-free after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: Breast tumor: ER/PR positive, HER2 negative. Lung tumor: KRAS/EGFR wild type, ALK rearrangement not detected.

As of April 2014, more than 2 years of follow-up showed no recurrent disease after treatment of synchronous Stage IA breast cancer and Stage IIA lung adenocarcinoma.

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Stage IIIB lung adenocarcinoma with separate papillary renal cell carcinoma: doing well more than 6 years after revised diagnosis

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: Lung tumor: TTF-1-positive; PET-avid. Kidney lesion: PET-negative; later papillary renal cell carcinoma. No lung molecular biomarkers reported.

As of February 2014, she was doing well more than 6 years after the initial diagnosis, after the diagnosis was revised from presumed Stage IV lung cancer to Stage IIIB lung adenocarcinoma plus a separate papillary renal cell carcinoma.

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Stage IV NSCLC: near-complete response despite severe docetaxel-induced diarrhea

Patient Info: Anonymized, Male, 70+ | Stage IV

As of October 2013, he had completed 6 cycles of weekly docetaxel-cisplatin with dose reduction and supportive care, resulting in a near-complete response.

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