Gastric adenocarcinoma spreads to the liver and esophageal mucosa

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver, esophageal mucosa

The metastatic disease progressed despite 3 cycles of second-line docetaxel plus cisplatin.

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Ovarian Dysgerminoma Treatment Followed by Bleomycin-Related Skin Changes

Patient Info: Anonymized, female, Under 40

A 23-year-old woman treated for ovarian dysgerminoma developed persistent streak-like skin darkening after bleomycin-containing chemotherapy.

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Stage IIIA squamous lung cancer with later kidney and paraaortic lymph node metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Squamous lung cancer markers supported the diagnosis; TTF-1, CK7 and CK20 were not seen; Ki-67 >10%.

Metastatic Site: left renal parenchyma, paraaortic lymph nodes

After surgery, 4 cycles of cisplatin plus vinblastine, and mediastinal radiotherapy, she had a 10-month disease-free interval before biopsy-confirmed metastatic squamous lung carcinoma appeared in the left kidney with paraaortic lymph node enlargement.

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Ovarian serous adenocarcinoma returns as a solitary gastric metastasis more than 12 years later

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: stomach

At the latest follow-up, she had no recurrence after resection of the gastric metastasis, more than 12 years after her original ovarian-cancer surgery.

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Metastatic gastric adenocarcinoma presents with severe breathing problems in a 24-year-old man

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: lungs, pleura, mediastinal lymph nodes, bone

After 2 months of chemotherapy, imaging showed a partial response in the stomach and metastatic sites, and his breathing symptoms resolved without further oxygen support.

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Mucinous Ovarian Cancer Treated During Pregnancy

Patient Info: Anonymized, female, Under 40 | Stage I

The woman and her baby were followed for more than 5 years, and the mother had no evidence of ovarian cancer recurrence during that period.

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Stage IIIA pleomorphic lung cancer treated with surgery, chemotherapy, and radiation

Patient Info: Anonymized, Male, Under 40 | Stage III

Alive 14 months after surgery without evidence of tumor recurrence after complete resection, adjuvant chemotherapy, oral S-1, and radiation.

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Stage IV lung squamous cell carcinoma with liver metastasis treated with chemotherapy and 90Y radioembolization

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: liver

After treatment for liver metastasis, PET CT 2 months after 90Y radioembolization showed complete tumor response without residual tumor, and she was alive without active disease.

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Stage III Ovarian Cancer in a BRCA1 Carrier With Long-Term Disease Control

Patient Info: Anonymized, 60s | Stage III

Biomarkers: BRCA1 mutation

At the latest follow-up in January 2012, she had no recurrence of ovarian cancer and was well.

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Recurrent Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Multiple Therapies

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

By late 2011, hilar nodal disease was slowly progressing and bevacizumab was started for the recurrent ovarian cancer.

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Recurrent Stage III Ovarian Cancer Complicated by Severe Kidney Injury

Patient Info: Anonymized, female, 70+ | Stage III

After further intra-abdominal cancer progression and severe kidney injury, she developed seizures, encephalopathy, and limb ischemia and died 1 week after hospitalization in May 2011.

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Stage IV lung adenocarcinoma with brain metastasis: partial remission after pemetrexed/cisplatin and AOSD-like paraneoplastic syndrome

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: No tumor molecular biomarkers reported. AOSD-like syndrome had high ferritin, inflammation markers, and RF/ANA negative.

Metastatic Site: brain

As of November 2011, pemetrexed/cisplatin produced partial remission of Stage IV lung adenocarcinoma and controlled the AOSD-like paraneoplastic syndrome without recurrent fever, rash, or arthralgia.

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Stage IV lung adenocarcinoma: partial responses to cisplatin-docetaxel and erlotinib, complicated by fistula

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Tumor genomic biomarkers not reported. EGFR testing result not reported; erlotinib was used as second-line therapy.

Metastatic Site: contralateral lung, pleura

Metastatic lung adenocarcinoma had partial response to chemotherapy and persistent partial response on erlotinib; after erlotinib was stopped for enterocutaneous fistula, she was alive and well without evidence of lung-cancer progression.

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Large cell lung carcinoma with solitary jejunal metastasis: no evidence of disease 4 years after treatment

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary lung tumor and jejunal metastasis shared a KRAS codon 61 mutation; staining supported lung origin.

Metastatic Site: jejunum

As of January 2010, she was doing well with no evidence of disease 4 years after diagnosis and treatment of a solitary jejunal metastasis from large cell lung carcinoma.

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