RET-rearranged metastatic lung cancer responding to selpercatinib after pralsetinib

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: KIF5B-RET fusion; PD-L1 negative

Metastatic Site: brain

More than 5 years after her 2018 diagnosis, selpercatinib was ongoing after 8 months with continued brain response and stable lung disease.

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Stage IIIA NSCLC: recurrence-free after surgery, adjuvant chemotherapy, and one atezolizumab dose

Patient Info: Anonymized, Female, 60s | Stage III

Biomarkers: PD-L1 expression 20% by 22C3 assay

She remained free of lung-cancer recurrence for more than 1 year after surgery and adjuvant cisplatin/vinorelbine; atezolizumab was stopped after 1 dose because of severe immune-related toxicities that improved with steroid and immunoglobulin treatment.

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EGFR-mutant lung adenocarcinoma in Li-Fraumeni syndrome: relapse-free after lobectomy and chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Lung tumor had EGFR exon 19 deletion. Germline TP53 variant was consistent with Li-Fraumeni syndrome; prior breast cancers were HER2 positive.

As of July 2024, she was free of relapse 2 years after left inferior lobectomy and pemetrexed/cisplatin for EGFR exon 19 deletion lung adenocarcinoma.

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Small cell lung cancer with SIADH that progressed after an initial response to treatment

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: liver

The cancer progressed with disseminated liver metastases, and she died from liver failure in February 2021.

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Stage IV small cell lung cancer with metastases involving bone and both eye muscles

Patient Info: Anonymized, male, 40s | Stage IV

Metastatic Site: bone; bilateral extraocular muscles (orbits)

He died 5 months after presenting with bilateral orbital involvement while receiving palliative treatment for Stage IV small cell lung cancer.

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Stage III small cell lung cancer complicated by a tracheomediastinal fistula during chemoradiation

Patient Info: Anonymized, male, 70+ | Stage III

Four months after treatment began, there was no evident cancer recurrence, although the persistent fistula remained under consideration for repair.

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Stage IV lung adenocarcinoma complicated by visceral leishmaniasis during chemotherapy

Patient Info: Anonymized, male, 50s | Stage IV

Biomarkers: EGFR wild-type; ALK negative; ROS negative; PD-L1 negative

Imaging showed progression while maintenance pemetrexed was temporarily interrupted; pemetrexed was then restarted during treatment for visceral leishmaniasis.

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ALK-positive lung adenocarcinoma complicated by crizotinib-associated kidney and liver cysts

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: ALK fusion

Metastatic Site: bone

After switching from crizotinib to alectinib, the lung cancer and hilar lymph nodes remained stable at the latest follow-up described.

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EGFR L858R/S768I lung adenocarcinoma with more than 5 years of survival after targeted therapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR L858R and S768I compound mutation

Metastatic Site: bone, brain

He died on August 15, 2022, about 5 years and 4 months after his April 2017 presentation; afatinib had provided more than 3 years of disease control before later bone and brain progression.

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Stage II lung adenocarcinoma with severe atezolizumab-related myocarditis after surgery

Patient Info: Anonymized, female, 40s | Stage II

Biomarkers: PD-L1 TPS 50%

More than 1 year after atezolizumab was discontinued, there was no recurrence of the lung cancer.

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Stage III squamous lung cancer controlled during treatment while a second pancreatic cancer developed

Patient Info: Anonymized, female, 50s | Stage III

Biomarkers: KRAS exon 2 mutation

She died in March 2022. Her Stage III lung cancer had remained controlled for about 18 months, while a separate pancreatic cancer developed and progressed.

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Metastatic rectal cancer treated during pregnancy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: CEA within normal limits at diagnosis

Metastatic Site: distant lymph nodes including para-aortic,…

Rectal bleeding stopped after chemotherapy, and PET-CT after cycle 3 showed a partial response in the rectal tumour and several involved lymph-node regions.

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Stage III small-cell lung cancer had a complete response after chemo-immunotherapy and surgery

Patient Info: Anonymized, female, 50s | Stage III

Surgery showed a pathological complete response, and no recurrence or metastasis was found through 12 months of follow-up.

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First reported case of a severe immune reaction (cytokine release syndrome) from tislelizumab

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: pleura (malignant pleural effusion)

The cytokine release syndrome initially improved with high-dose steroids, but he developed severe ventilator-associated pneumonia during the steroid taper and died.

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Metastatic gastric neuroendocrine carcinoma treated with repeated chemotherapy and immunotherapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver, pancreas

More than 3 years after diagnosis, he remained in good condition on fifth-line treatment. April 2023 CT showed shrinkage of liver and pancreatic-tail metastases.

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Rare anorectal melanoma that spread to the liver, lungs, and lymph nodes

Patient Info: Anonymized, Male | Stage IV

Metastatic Site: liver; lungs; lymph nodes

Five months after completing treatment, he presented with severe respiratory distress and died 4 days later.

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Localized Linitis Plastica With Gastric Amyloidosis Followed by Multiple Myeloma

Patient Info: Anonymized, Female

Biomarkers: CA19-9: 47.5 U/mL

She remained in clinical remission for 3 years after gastric cancer treatment, and later CT imaging showed no recurrent gastric disease when multiple myeloma was diagnosed.

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Rare small cell lung cancer subtype removed by surgery

Patient Info: Anonymized, Male

Biomarkers: Cytokeratin-negative; focal TTF-1-positive; Napsin A-negative; electron microscopy showed neurosecretory granules; EWSR1 and SS18 rearrangement testing negative

Follow-up scans found no residual, recurrent or metastatic lung cancer, and he was doing well.

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Solitary adrenal metastasis after surgery for gastric large-cell neuroendocrine carcinoma

Patient Info: Anonymized, male | Stage IV

Metastatic Site: right adrenal gland

Nine months after removal of the adrenal metastasis, he was alive and August 2022 CT showed no new metastases or tumor recurrence.

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Growing Masses After Chemotherapy for an Ovarian Germ Cell Tumor

Patient Info: Anonymized, Female, Under 40

Biomarkers: AFP 581.2 ng/mL and CA-125 74.3 U/mL after surgery

Despite 6 chemotherapy cycles and normalization of AFP, abdominal and pelvic masses continued to grow while CA-125 and CEA increased. She sought a second opinion and underwent imaging and biopsy of an abdominal mass.

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Stage III Testicular Cancer: Felipe's Survivor Story

Patient Info: Felipe Soltero, Male, Under 40 | Stage III

Biomarkers: alpha-fetoprotein elevated; lactate dehydrogenase elevated

After surgery and BEP chemotherapy for Stage III metastatic testicular cancer, Felipe was cancer-free for more than 1 year as of October 2022.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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Severe kidney injury during pembrolizumab-based treatment for lung adenocarcinoma

Patient Info: Anonymized, Male, 70+

Kidney function stabilized during six months of follow-up, and he later began a modified cancer regimen containing SAR408701.

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Early kidney injury after first-line treatment for lung adenocarcinoma

Patient Info: Anonymized, Male, 70+

Kidney function improved after a short prednisone course, and he later continued cancer care with carboplatin and nab-paclitaxel.

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