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A 29-year-old man was admitted in December 2015 with upper-abdominal pain and a 6-kg weight loss. Endoscopy found an infiltrative gastric-body lesion, and biopsy showed mixed-type gastric adenocarcinoma. CT, PET-CT and staging laparoscopy confirmed diffuse peritoneal metastases, making this Stage IV disease.
He first received 12 cycles of modified DCF chemotherapy with docetaxel, cisplatin and 5-fluorouracil. A repeat laparoscopy still showed substantial peritoneal disease. He then received laparoscopic HIPEC with cisplatin and docetaxel followed by 3 cycles of combined systemic and intraperitoneal chemotherapy using the BISIC approach.
Further staging showed progression of the peritoneal cancer, so the planned radical surgery was not performed. He moved to second-line treatment with paclitaxel and ramucirumab. The disease progressed during the second cycle, and he died from complications related to the cancer in April 2017, about 16 months after his admission.
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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