Stage IV Colorectal Adenocarcinoma: Kyle's Survivor Story

Patient Info: Kyle, Under 40 | Stage IV

Kyle was 19 months NED and off treatment after Stage IV colon adenocarcinoma, following about 30 months of chemotherapy and targeted therapy.

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Stage III Breast Cancer: Alexandra's Patient Story

Patient Info: Alexandra, Female, 40s | Stage III

As of 2021, Alexandra was living with Stage III breast cancer and continuing chemotherapy after treatment with docetaxel, carboplatin, antibody drug conjugates, and tamoxifen.

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Stage III Colorectal Cancer: Hilmi's Patient Story

Patient Info: Hilmi | Stage III

Hilmi was still undergoing chemotherapy and remained focused on recovery while managing a stoma and treatment side effects.

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Metastatic NRG1-Fusion Lung Cancer Responding to Long-Term Afatinib

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: CD74-NRG1 fusion

Metastatic Site: lungs

As of February 2020, she remained on afatinib 30 mg daily with an ongoing partial response after 27 months.

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Stage I Colorectal Cancer: Paul's Survivor Story

Patient Info: Paul | Stage I

Completed treatment and described the cancer as beaten, with the goal of continuing life without cancer.

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Stage III Breast Cancer: Kelly's Patient Story

Patient Info: Kelly, Female, 40s | Stage III

Kelly had Stage III breast cancer diagnosed around 2021, with treatment that included mastectomy, lymphadenectomy, chemotherapy, and radiation therapy; after a treatment change, she was still receiving radiation therapy.

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Stage IV Breast Cancer: Rachael's Patient Story

Patient Info: Rachael | Stage IV

Rachael was living with stage 4 breast cancer after following a plan of mastectomy, chemotherapy, and radiation therapy.

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Breast Cancer: Vivienne's Survivor Story

Patient Info: Vivienne

Vivienne said she was in remission after completing most of her treatment and continued hormone therapy.

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Colon Cancer With an MLH1 Deletion and Lynch Syndrome

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: dMMR with loss of MLH1 and PMS2. Familial MLH1 c.1057_1060delGCTG frameshift deletion identified; its clinical significance had not previously been reported.

The colon cancer progressed rapidly despite postoperative and second-line therapy, and he died from multiple organ failure one week after pembrolizumab was started.

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Recurrent NRG1-Fusion Lung Cancer After Surgery and Immunotherapy

Patient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced

Biomarkers: SDC4-NRG1 fusion

He chose no further treatment after rapid progression on afatinib and died shortly afterward in hospice.

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Stage II HER2-Positive Breast Cancer: Kelsey's Survivor Story

Patient Info: Kelsey, Female, 40s | Stage II

Biomarkers: HER2-positive

Kelsey survived Stage II HER2-positive breast cancer after mastectomy, chemotherapy, and targeted therapy, with recovery supported by nutrition changes, massages, supplements, and support-group connection.

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Stage II Gastric Cancer: Andy's Patient Story

Patient Info: Andy | Stage II

Andy was still undergoing treatment and reported that targeted therapy was the current treatment.

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Stage IV Mucinous Lung Cancer Treated With Afatinib and Surgery

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: CD74-NRG1 fusion; ALK/ROS1/EGFR/BRAF/KRAS/MET/HER2 wild type; PD-L1 initially not expressed and later 0%-20%

Metastatic Site: bilateral lungs|bone|right adrenal gland

She was alive and receiving treatment after bone and right-adrenal progression at the latest follow-up.

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Nearly 5 years without rectal cancer recurrence when a lung nodule proved to be infection

Patient Info: Anonymized, Male, 60s

He remained without rectal-cancer recurrence for nearly 5 years after diagnosis. A new lung nodule found in 2020 was surgically biopsied and proved to be Pneumocystis infection rather than metastasis or a new lung cancer.

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Colorectal Cancer: Percy's Survivor Story

Patient Info: Percy

Completed treatment and described the cancer as being in remission.

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Breast Cancer: Maria's Patient Story

Patient Info: Maria

Maria underwent mastectomy, lymph-node surgery, chemotherapy, and radiation and continued to work through fear that the treatment might not succeed.

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Recurrent Mucinous Lung Cancer With Dose-Dependent Afatinib Responses

Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced

Biomarkers: SDC4-NRG1 fusion; PD-L1 not expressed; low tumor mutation burden

Metastatic Site: bilateral lungs

She had progressive lung disease after several targeted-treatment attempts and was receiving paclitaxel with bevacizumab as of February 2020.

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Stage II Breast Cancer: Erika's Patient Story

Patient Info: Erika, Female, 40s | Stage II

As of 2021, Erika was undergoing treatment for Stage II breast cancer and was on targeted therapy after mastectomy, lymphadenectomy, chemotherapy, and targeted therapy.

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Stage I Breast Cancer: Mariana's Patient Story

Patient Info: Mariana | Stage I

Mariana completed lumpectomy, chemotherapy, and radiation and continued to work through fear of lasting chemotherapy effects.

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Metastatic Right-Sided Colon Cancer With an NRG1 Fusion

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS mutation; POMK-NRG1 fusion

Metastatic Site: liver|lungs

He had persistent metastatic disease after 16 months of afatinib and entered a phase I trial in January 2020.

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Stage II HR-Positive Breast Cancer: Faith's Survivor Story

Patient Info: Faith, Female, Under 40 | Stage II

Biomarkers: ER-positive; HER2-positive

Faith moved into survivorship after treatment for Stage II ER-positive, HER2-positive breast cancer, with ongoing fear of recurrence but renewed focus on family, nutrition, exercise, and work.

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Stage II Breast Cancer: Marisol's Survivor Story

Patient Info: Marisol | Stage II

Marisol said the breast cancer was in remission after completing most active treatment, and she continued hormone therapy.

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Stage II Breast Cancer: Shamala's Survivor Story

Patient Info: Shamala | Stage II

Shamala says she is free of cancer and in remission after treatment.

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Stage II Gastric Cancer: Mawar's Patient Story

Patient Info: Mawar, female | Stage II

Mawar chose to discontinue further treatment after surgery and chemotherapy and focused on family life while remaining concerned that the gastric cancer could worsen.

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