A Woman With Prior Breast Cancer Later Faced Metastatic Pancreatic Cancer and Recurrent Strokes

Patient Info: Anonymized, Female, 60s

Her breast cancer had previously been treated with mastectomy and adjuvant chemotherapy before a later hospitalization centered on metastatic pancreatic cancer and recurrent embolic strokes.

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Aggressive Presumed Ovarian Solid Pseudopapillary Tumor With Widespread Metastases

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: peritoneum|pelvic soft tissue|inguinal lymph…

The disease progressed rapidly across multiple abdominal and nodal sites. She died from disease-related complications 2 months after the oncology consultation while receiving induction chemotherapy.

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Stage IV EGFR Non-Small Cell Lung Cancer: Saila's Patient Story

Patient Info: Saila Hanninen, Under 40 | Stage IV

Biomarkers: EGFR mutation

After progression on earlier EGFR-directed treatment and other therapies, Saila began chemotherapy and her cancer was stable at the time of the story.

Dana-FarberRead more →

Stage III Invasive Lobular Carcinoma: Barb's Survivor Story

Patient Info: Barb, Female | Stage III

As of December 2020, Barb was in survivorship after bilateral mastectomy, chemotherapy, radiation, and 2 reconstruction revision surgeries for Stage III invasive lobular breast cancer.

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Breast Adenoid Cystic Carcinoma Treated With Mastectomy and Chemotherapy

Patient Info: Anonymized, Female

She remained recurrence-free through the follow-up period ending in June 2020.

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Breast Adenoid Cystic Carcinoma Treated With Breast-Conserving Surgery

Patient Info: Anonymized, Female

She remained recurrence-free through the follow-up period ending in June 2020.

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Ovarian Cancer: Lauren's Survivor Story

Patient Info: Lauren Wells, Female, Under 40

Lauren was described as cancer-free and making a strong recovery while continuing physical, occupational, and speech therapy.

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Blood Vessel Inflammation After Durvalumab Treatment for Stage III Lung Cancer

Patient Info: Anonymized, Female, 70+ | Stage III

The lung cancer had responded well to chemoradiation and durvalumab, while treatment-related pneumonitis and vasculitis improved with corticosteroids and withdrawal or completion of durvalumab.

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Ovarian Cancer: Elle's Patient Story

Patient Info: Elle Simone, female

Elle was dealing with an ovarian cancer recurrence while continuing her work and advocacy.

HER2-positive breast cancer diagnosed during pregnancy and later spread to bone and brain

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Initial tumour: ER 0%, PR <1%, HER2 3+

Metastatic Site: bone (L3)|brain

After treatment and surveillance without new lesions, she developed a large symptomatic occipital brain metastasis 14 months after completing paclitaxel and radiation and died after rapid neurological deterioration.

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Hemodialysis used to manage 5-FU toxicity during treatment of Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: para-aortic lymph nodes, meninges

After a partial response to 7 cycles of chemotherapy, carcinomatous meningitis developed. Treatment was stopped, best supportive care was started, and he died 2 months later.

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Colon Cancer Survivor: "I Didn't Think I Had Symptoms, Diagnosed Stage 3B" | Shelley's Story

Patient Info: Shelley Brown, Female | Stage III

As of October 2020, Shelley was in remission / no evidence of disease several years after Stage IIIB sigmoid colon cancer treatment, with ongoing surveillance by scans, CEA, and colonoscopy.

The Patient StoryRead more →

Sjögren syndrome during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, lungs, adrenal gland

One year after nivolumab was stopped, the shrinkage of lung metastases was maintained and the adrenal metastasis remained unchanged, although severe dry-mouth symptoms from treatment-related Sjögren syndrome persisted.

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Stage II Triple-Negative Breast Cancer: Jessica's Survivor Story

Patient Info: Jessica Duemig, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative

As of October 2020, Jessica had been considered cured since February 2020 after treatment for Stage IIA triple-negative metaplastic breast cancer and was described as living life to the fullest about 3 years after diagnosis.

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Dural metastasis causing seizures after treatment for signet-ring gastric cancer

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: dura mater

She died 16 days after hospital admission for neurologic symptoms, roughly 8 months after the original gastric-cancer diagnosis, following rapid deterioration from diffuse dural metastatic disease.

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Stage IIIA Right Breast Cancer Followed by a Late Radiation Nerve Injury

Patient Info: Anonymized, Female, 50s | Stage III

Imaging in January 2019 found no evidence of breast-cancer recurrence, although she had developed radiation-induced brachial plexopathy.

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Triple-Negative Breast Cancer Treated With Mastectomy and Chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Triple-negative.

The later accessory-breast-tissue cancer was considered a separate new primary after a five-year interval, and she was currently without evidence of disease.

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A New Breast Cancer Arising Beneath an Accessory Nipple

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 5%; PR 5–10%; HER2-negative.

After chemotherapy, surgery, endocrine therapy, proton radiation, and later reconstruction revision, she was currently without evidence of disease.

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Stage III Colorectal Cancer: Ben's Survivor Story

Patient Info: Ben Simcox, Male, Under 40 | Stage III

As of September 2020, Ben was cancer-free for almost 3 years after treatment for rectal cancer with 3 positive lymph nodes, including chemotherapy, radiation, surgery and 6 additional months of chemotherapy.

Cleveland ClinicRead more →

Stage III Ovarian Cancer: Jackie's Survivor Story

Patient Info: Jackie Page, Female, 50s | Stage III

In remission with no sign of recurrent disease at the September 2020 publication, while continuing treatment on the clinical trial.

Dana-FarberRead more →

Treatment-Related Inflammation Mimicked Metastatic Colon Cancer Recurrence

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver|peritoneum

Biopsy showed that new lymph-node, liver, and spleen findings were a treatment-related sarcoid-like reaction rather than recurrence, and 18 months of surveillance found no evidence of cancer.

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Colon Cancer Metastasis Found Inside a Thyroid Nodule

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: KRAS mutated; thyroid metastasis CDX2 positive and CK20 positive; PAX8/TG/TTF-1 negative

Metastatic Site: lungs|thyroid

Follow-up was planned after thyroid surgery, with no adjuvant treatment for the coexisting low-risk thyroid lesion.

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Stage IV Colorectal Cancer: Scott's Patient Story

Patient Info: Scott Sterling, 50s | Stage IV

Metastatic Site: liver

After nearly 2 years of treatment for Stage IV colorectal cancer, Scott was able to have his primary tumor removed in August 2020 and was recovering while the metastatic disease continued to be managed.

Dana-FarberRead more →

Graves disease during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, brain

After progression through several treatment lines and development of brain metastasis, he died 4 months after evaluation for nivolumab-associated Graves disease, more than 1.5 years after his Stage IV gastric-cancer diagnosis.

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