Rectal cancer surgically treated during care for synchronous esophageal cancer

Patient Info: Anonymized, Male, 60s

At 24-month follow-up, there was no evidence of rectal cancer.

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Stage IV Colorectal Cancer: Rachael's Patient Story

Patient Info: Rachael, Female, Under 40 | Stage IV

Metastatic Site: Ovaries; liver

As of January 2025, Rachael had completed intensive chemotherapy for Stage IV sigmoid colon cancer involving the ovaries and liver and was awaiting scans to determine whether liver surgery and HIPEC would be next.

The Patient StoryRead more →

How I Found Out I Had Stage 4 Colon Cancer!

Patient Info: Rachael Marie, Female, Under 40 | Stage IV

Metastatic Site: ovaries, liver

Rachael completed 12 cycles of FOLFOX/oxaliplatin; colonoscopy looked clear, liver lesions had shrunk, and no new lesions were reported, with further surgical planning pending.

The Patient StoryRead more →

Metastatic MSI-H colon cancer reaches pathologic complete response after immunotherapy and bevacizumab

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: KRAS, MSI-H

Metastatic Site: liver

The resected liver lesions showed pathologic complete response, and the last CT/MRI in November 2023 showed no recurrence or metastasis, more than 5 years after diagnosis.

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Stage IIIC triple-negative breast cancer with pembrolizumab-related HLH/DIC and pathologic complete response

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative/HR-negative breast cancer with germline BRCA1 pathogenic mutation. HLH/DIC episode had high IL-6

Surgery confirmed ypT0ypN0 pathologic complete response after neoadjuvant carboplatin, paclitaxel, and pembrolizumab, and she remained recurrence-free while being monitored without additional cancer-directed treatment.

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Stage IB lung adenocarcinoma: thoracoscopic lobectomy with anomalous pulmonary vein anatomy

Patient Info: Anonymized, Female, 50s | Stage I

Stage IB lung adenocarcinoma was treated with thoracoscopic left lower lobectomy and lymph-node dissection; she recovered uneventfully and was discharged on postoperative day 3.

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Stage II Breast Cancer: India's Survivor Story

Patient Info: India Robinson, Female, 40s | Stage II

As of January 2025, India had completed Stage II breast cancer treatment and had returned to work, the gym and daily life after robotic lymphatic microsurgery resolved breast lymphedema; the story does not explicitly state NED.

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Rectal adenocarcinoma causing severe secretory diarrhea and kidney failure

Patient Info: Anonymized, Male, 70+

He recovered without surgical complications and had marked improvement in strength and quality of life during the first 30 postoperative days.

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Stage IV Colorectal Cancer: Roshonda's Patient Story

Patient Info: Roshonda, Female | Stage IV

Metastatic Site: Lung

As of January 2025, Roshonda was living after treatment for Stage IV rectal cancer with a lung spot, including chemoradiation, IV chemotherapy, and permanent colostomy surgery.

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Stage IV Colorectal Cancer: Roshonda's Survivor Story

Patient Info: Roshonda Clark, Female, 40s | Stage IV

Roshonda completed chemoradiation and permanent-colostomy surgery, returned to work, and described living day by day with recurrence worries but no active treatment reported.

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Stage I Triple-Negative Adenoid Cystic Carcinoma of the Breast

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: Triple-negative

At 6-month follow-up, imaging showed no recurrence or new cancer-related complications.

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Breast Cancer Responses During Mistletoe Extract and Intratumoral Influenza Vaccine Treatment — Case 1

Patient Info: Anonymized, female, 60s

Biomarkers: Initial ER 100%, PR 60%, HER2-negative; recurrence ER 100%

She remained in remission 3 years after surgery for the local recurrence.

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Stage IIIA squamous lung cancer: surgery after nivolumab-related complications

Patient Info: Anonymized, Female, 70+ | Stage II

Biomarkers: PD-L1 TPS 99% before treatment; PD-L1 TPS 70% in postoperative hilar lymph node; TPOAb and TgAb normal during thyroiditis workup

As of January 2025, the patient had no recurrence 7 months after neoadjuvant nivolumab/carboplatin/paclitaxel and 5 months after thoracoscopic right upper lobectomy with lymph node dissection.

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Breast Cancer Responses During Mistletoe Extract and Intratumoral Influenza Vaccine Treatment

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: bone, lungs, pleura

After a mixed radiologic response, she declined further imaging and remained in good condition without clinical evidence of further progression.

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ALK-Positive Metastatic Lung Cancer Responding to Lorlatinib During Hemodialysis

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: ALK rearrangement 80%; EGFR and BRAF negative; ROS1 negative; PD-L1 negative

Metastatic Site: brain

After about 1 year of lorlatinib, imaging was almost compatible with a complete response, brain MRI showed no active lesions, and she continued treatment with manageable high cholesterol as the main reported side effect.

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Metastatic breast cancer with receptor evolution: sequential endocrine, immunotherapy, CDK4/6, and antibody-drug conjugate treatment

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Markers changed over time: initial tumor ER-positive/HER2-negative; local recurrence triple-negative/HER2-low; pleural fluid ER-negative.

Metastatic Site: mediastinal lymph nodes, pleura; pulmonary nodules…

More than 7 years after diagnosis, she remained on sequential systemic therapy for metastatic breast cancer, with at least a partial response 3 months after starting sacituzumab govitecan for presumed triple-negative pleural disease.

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Lung Adenocarcinoma That Transformed to Small Cell Cancer After Recurrence

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: PD-L1 1%-24%; no druggable driver alteration identified

Metastatic Site: brain, liver

After treatment for the small-cell-transformed recurrence, the liver metastases showed sustained regression and progression-free survival had reached 13 months by September 2024.

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Gastric cancer recurring in the rectum about 20 months after gastrectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: rectum, peritoneum

Metastatic gastric adenocarcinoma involved the rectum and pericolonic fat, with peritoneal nodules seen at surgery. He died 6 months after the rectal operation.

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Stage IV cecum cancer with liver and ovarian metastases: ramucirumab-related nephrotic syndrome and glomerular microangiopathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Cancer biomarkers were not reported. Kidney injury workup showed severe protein leakage and biopsy-proven glomerular microangiopathy.

Metastatic Site: liver, right ovary

The liver metastasis shrank after XELOX plus bevacizumab and metastatic liver/ovarian sites were resected, but ramucirumab-based second-line therapy was stopped after nephrotic syndrome and severe glomerular microangiopathy; blood pressure and proteinuria improved with telmisartan.

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Node-positive breast cancer history with biopsy-related subclavian vein pseudoaneurysm repair

Patient Info: Anonymized, Female, 40s

The pseudoaneurysm was surgically excised and the subclavian vein repaired primarily. She recovered uneventfully, was discharged on postoperative day 3, and at 6 weeks had no recurrence, no wound complications, and a normal right-arm neurovascular exam.

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EGFR-Mutant Lung Cancer With Pleomorphic Transformation Treated With Local Surgery

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: EGFR L858R mutation; PD-L1 less than 1% initially and greater than 75% after transformation

Metastatic Site: brain

Nine months after surgery for isolated progression, no recurrence had been seen and she remained on osimertinib.

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Gastric cancer recurring in the rectum 7 months after total gastrectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: rectum

Rectal metastasis developed 7 months after gastrectomy. He entered hospice-led end-of-life care and died 2 months after the metastatic rectal diagnosis.

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Stage 3 squamous cell lung cancer: major response to chemo-immunotherapy

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: PD-L1 30-40%

After neoadjuvant chemoimmunotherapy and sleeve right lower lobectomy, pathology showed major pathological response with negative margins, and no metastasis or recurrence was observed 6 months after surgery.

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HER2-Positive Breast Cancer With Metastatic Progression and Drug-Induced Lupus During T-DM1

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-positive

Metastatic Site: bones, axillary lymph nodes, intra-abdominal lymph…

More than 5 years after her March 2018 diagnosis, she was living with metastatic breast cancer, but T-DM1 had been stopped after disease progression in 2023.

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