HER2-Positive Breast Cancer With Metastatic Progression and Drug-Induced Lupus During T-DM1

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-positive

Metastatic Site: bones, axillary lymph nodes, intra-abdominal lymph…

More than 5 years after her March 2018 diagnosis, she was living with metastatic breast cancer, but T-DM1 had been stopped after disease progression in 2023.

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Cecal cancer discovered after severe Clostridium septicum infection and neurologic injury

Patient Info: Anonymized, Male, 60s

The cecal tumor was surgically removed. He was discharged in stable condition but still had substantial neurologic deficits from the preceding septic embolic illness.

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Localized low-grade bronchial chondrosarcoma: surgery with no recurrence at 12 months

Patient Info: Anonymized, Male, 50s

Biomarkers: No molecular biomarkers reported. Histology showed a low-grade cartilage-type tumor.

As of December 2025, follow-up bronchoscopy, CT, and clinical evaluation through 12 months after surgery showed good healing and no recurrence.

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Treating Breast Asymmetry After Breast Cancer Surgery and Radiation

Patient Info: Anonymized, Female, 50s

By February 2024, about 2 years after breast-cancer surgery and radiation, she had completely recovered from the oncological condition.

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Lung Adenosquamous Carcinoma Arising From a Long-Standing Bronchogenic Cyst

Patient Info: Anonymized, female, 70+

Biomarkers: KRAS G12D mutation; PD-L1 TPS 60%; EGFR/BRAF/ROS1/ALK negative

She remained in remission 2.4 years after surgery despite stopping atezolizumab early because of immune-mediated colitis.

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Stage I triple-negative solid basaloid adenoid cystic breast cancer treated with mastectomy and oral chemotherapy

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Current tumor was triple-negative with high Ki-67 and c-kit/CK7 staining. Prior breast cancer was ER-positive, HER2-positive, PR-negative.

One year after mastectomy and postoperative tegafur-gimeracil-oteracil potassium, she was recovering well without signs of metastasis.

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Two sisters with invasive lobular breast cancer and a shared CDH1 mutation

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Biomarkers: Both sisters had pathogenic CDH1 p.. Breast cancers were HER2-negative; older sister also had a PTCH1 variant of uncertain significance.

As of January 2025, both sisters were under ongoing hereditary diffuse gastric cancer surveillance with annual EGD after breast cancer treatment; no signs of HDGC or metastatic breast cancer were reported.

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Stage II Colorectal Adenocarcinoma: Carmen's Patient Story

Patient Info: Carmen | Stage II

Carmen remains on chemotherapy after surgery and radiotherapy for Stage II colon cancer.

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Prior breast cancer treated with radiation, then radiation-related heart damage

Patient Info: Anonymized, Female, 60s

Breast cancer treatment had been completed 10 years earlier; the case mainly documents successful surgery for radiation-associated coronary and aortic valve disease, with no major cardiac events at 5 years.

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Stage II Colorectal Cancer: Casandra's Survivor Story

Patient Info: Casandra | Stage II

Casandra was declared cancer-free in February 2025 and continues to cope with fatigue, fear of recurrence and mistrust after a prolonged diagnostic delay.

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Stage I lung adenocarcinoma: no recurrence after thoracoscopic lobectomy

Patient Info: Anonymized, Male, 60s | Stage I

No recurrence at 3 months after thoracoscopic right upper lobectomy for pT1cN0M0 lung adenocarcinoma; no additional treatment was needed.

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Lung adenocarcinoma mimicking interstitial lung disease: Stage IIB diagnosis after VATS biopsy

Patient Info: Anonymized, Male, 50s | Stage II

Biomarkers: CK7-positive; CK20-positive; TTF-1-positive; CDX2-negative; no EGFR/ALK/ROS1/KRAS molecular results provided

As of January 2025, he had recovered from diagnostic VATS wedge resection/biopsies for reported Stage IIB lung adenocarcinoma and was referred for definitive oncology and pulmonology management.

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Stage IIB squamous cell lung cancer: pathological complete response after chemo-immunotherapy and surgery

Patient Info: Anonymized, Male, 60s | Stage II

Biomarkers: PD-L1 >85%; P40-positive; TTF-1-negative; CEA 1.2 ng/mL; cytokeratin 19 fragments 1.7 ng/mL; pro-gastrin-releasing peptide 54 pg/mL

No recurrence for 1 year and 7 months without further treatment after transbronchoscopic resection, pembrolizumab-based chemoimmunotherapy, pneumonitis management, and sleeve resection showing pathological complete response.

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Stage III Breast Cancer Complicated by a Large Liver Abscess

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: ER-positive, HER2-negative

Continuing adjuvant anastrozole and oncology follow-up after mastectomy for Stage III breast cancer.

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Stage 4 lung cancer: complete response to chemoimmunotherapy and surgery

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: EGFR exon 20 duplication with PD-L1 TPS 70%; P40/CK5/6 positive squamous markers; Ki-67 60%.

Metastatic Site: right adrenal gland; possible adjacent…

As of May 7, 2024, CT follow-up showed no evidence of disease after chemoimmunotherapy, conversion surgery with pathologic complete response, and pembrolizumab maintenance.

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Rare Bronchial Artery Pseudoaneurysm After Lung Cancer Surgery

Patient Info: Anonymized, male

A man in his early 50s underwent right upper-lobe surgery for invasive lung adenocarcinoma and later developed recurrent major bleeding from a rare bronchial artery pseudoaneurysm that was successfully embolized.

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Right lung cancer with incidental benign cardiac tumor before surgery

Patient Info: Anonymized, Female, 70+

No recurrence was detected at 6 months after staged right upper lobectomy and minimally invasive resection of a benign right atrial papillary fibroelastoma.

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ROS1-Positive Stage III Lung Adenocarcinoma With Pathologic Complete Response

Patient Info: Anonymized, male, 40s | Stage III

Biomarkers: ROS1 fusion-positive

Surgery found no residual cancer cells or involved lymph nodes, and no recurrence was detected during 10 months of crizotinib treatment and follow-up.

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Stage IV lung cancer: brain metastasis complete response after chemoimmunotherapy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS-mutated; BRG-1 partial loss; PD-L1 TPS 5%; CPS 20

Metastatic Site: brain (right cerebellar hemisphere)

The right cerebellar brain metastasis completely resolved and chest CT showed only postsurgical changes after carrelizumab plus paclitaxel/carboplatin; immune-mediated adrenal insufficiency improved with systemic glucocorticoids.

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Occult breast cancer with axillary lymph-node involvement: mastectomy and chemotherapy

Patient Info: Anonymized, Female, 50s

Biomarkers: Occult breast cancer was ER+/PR+, HER2 IHC 2+

Recurrence-free at 1 year after left nipple-sparing mastectomy, axillary lymph node dissection, and adjuvant chemotherapy for occult breast cancer with axillary nodal involvement.

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Stage IV luminal A breast cancer: liver resection and disease-free follow-up

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: luminal A; ER-positive; PgR-positive; HER2-negative

Metastatic Site: lung, liver

Disease-free after R0 hepatic segmentectomy for breast cancer liver metastasis, with May 2021 MRI showing no remaining liver nodules while she continued maintenance letrozole and goserelin.

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Stage III Large Cell Lung Cancer With Complete Response to Pembrolizumab-Based Treatment

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: PD-L1 TPS >60%; no actionable gene mutations identified

Imaging showed complete response of the recurrent hilar and mediastinal lymph nodes, and he remained progression-free through 24 cycles of treatment.

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Stage IV luminal B HER2-negative breast cancer with liver-limited metastasis resected after systemic therapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Luminal B; HER2-negative

Metastatic Site: liver

After liver segmentectomy for breast-cancer liver metastasis, follow-up imaging showed no remaining liver nodes, and she remained fit, well, disease-free, and on maintenance letrozole plus goserelin.

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Doctors Assured Me It Wasn’t Cancer!

Patient Info: Shirley, Female, Under 40 | Stage IV

Biomarkers: ALK-rearranged

Metastatic Site: mediastinum, pleura

Shirley was living with Stage IV ALK-positive lung cancer on a phase 2 ALK clinical trial; scans remained stable after 2 scan sets, but the large mass persisted.

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