Stage 2 secretory breast cancer: surgery alone with clear margins

Patient Info: Anonymized, Female, 40s | Stage II

Biomarkers: ER-positive; PR-negative; HER2-negative; secretory carcinoma; low grade

At 1-month follow-up after modified radical mastectomy, she had no surgical site infection, no arm lymphedema, no scapular winging, full shoulder range of motion, and no evidence of nodal or distant disease.

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Stage III Colorectal Cancer: Jackson's Survivor Story

Patient Info: Jackson, Male, Under 40 | Stage III

Jackson completed surgery and chemotherapy for Stage III colon cancer. After his final infusion on January 28, 2025, Signatera was negative, chest and abdomen CTs were clear, tumor-marker bloodwork was negative, and he was declared in remission/no evidence of disease; a later CT in June 2025 was also clear.

The Patient StoryRead more →

Malignant Phyllodes Tumor With Breast Rupture and 10 Years Without Recurrence

Patient Info: Anonymized, Female, 50s

No tumor recurrence was seen during 10 years of follow-up after mastectomy and radiation.

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Ruptured Malignant Phyllodes Tumor Treated With Emergency Mastectomy

Patient Info: Anonymized, Female, 70+

A 71-year-old woman with a rapidly growing, bleeding malignant phyllodes tumor required emergency mastectomy followed by radiation therapy.

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HER2-positive breast cancer with metastatic recurrence and complete response to T-DM1

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: HER2 IHC 3+ and hormone receptor-negative in primary and metastatic breast cancer; no liver metastases seen.

Metastatic Site: major pectoralis muscle, lung, broncho-hilar lymph…

After complete radiologic response on T-DM1, treatment was stopped after 22 months because of porto-sinusoidal vascular disorder. Seven months later, she remained asymptomatic and under surveillance with no signs of recurrent disease.

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HR-Positive Breast Cancer: Sara's Patient Story

Patient Info: Sara Glenn, Female, Under 40

Biomarkers: TP53 mutation / Li-Fraumeni syndrome; ER-positive; HER2-negative

As of June 2025, Sara had completed bilateral mastectomy and reconstruction for ER-positive, HER2-negative breast cancer and was on planned 10-year tamoxifen plus intensive Li-Fraumeni syndrome surveillance for herself and her daughters.

City of HopeRead more →

Prior breast cancer with chemoport-related SVC thrombosis causing chylothorax

Patient Info: Anonymized, Female, 70+

PET-CT ruled out residual malignancy, and the right chylothorax resolved within 48 hours after SVC angioplasty/stenting with no recurrence on 3-month follow-up imaging.

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Stage III Lung Cancer: Alexis's Survivor Story

Patient Info: Alexis, Female, Under 40 | Stage III

Biomarkers: No lung tumor biomarker reported

Alexis had Stage III pulmonary neuroendocrine/carcinoid cancer treated with removal of the entire left lung and 4 months of adjuvant pill chemotherapy. Follow-up scans after chemotherapy were clear, and her doctor called the status no evidence of disease; she continues long-term surveillance.

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Colorectal Cancer: Julie's Patient Story

Patient Info: Julie Goodrich

Nearly 2 years after surgery and 12 rounds of chemotherapy, Julie described herself as doing well.

Fight Colorectal CancerRead more →

BRCA1 Breast Cancer: Kathy's Survivor Story

Patient Info: Kathy Baker, Female

Biomarkers: BRCA1 mutation

As of June 2025, Kathy Baker was a breast and ovarian cancer survivor using her experience with BRCA1 testing to advocate for genetic testing access and cascade testing through My Faulty Gene.

Stage IV Colorectal Cancer: Jay's Survivor Story

Patient Info: Jay, Male, 40s | Stage IV

Metastatic Site: liver

Jay was diagnosed with Stage IV colon cancer in 2013 with extensive liver metastases. After surgery, systemic chemotherapy, hepatic arterial infusion pump therapy, liver resection, ablations, and prolonged chemotherapy, he became clear by 2016 and later described long-term survivorship.

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Stage IV Breast Cancer: Queen's Patient Story

Patient Info: Queen, Female, Under 40 | Stage IV

As of June 2025, Queen was living with Stage IV/metastatic breast cancer after multiple surgeries, setbacks, spread, and another tumor, while focusing on faith, self-advocacy, and living each day fully.

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Stage IV HER2-Positive Breast Cancer: Kathleen's Patient Story

Patient Info: Kathleen McEvoy-Schufreider, female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, bones

Kathleen continued long-term treatment for metastatic breast cancer, including infusions every 3 weeks after resuming the PATINA regimen outside the trial.

Dana-FarberRead more →

Stage I Pleomorphic Lung Cancer Recurring With Bone Metastasis Within Five Months

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: PD-L1 high; no detected driver mutation

Metastatic Site: bone

PET-CT in December 2024 showed a partial response. As of February 2025, he remained on sintilimab and bevacizumab maintenance with about 9 months of progression-free survival after recurrence treatment.

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Breast cancer history: T9 osteonecrosis mimicking spinal metastasis

Patient Info: Anonymized, Female, 50s

Biomarkers: ER status not explicitly reported; prior tamoxifen use reported

As of June 2025, the T9 lesion that had raised concern for spinal metastasis was confirmed as osteonecrosis, and eight-month follow-up showed no evidence of recurrence or new pain episodes.

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ALK-rearranged lung adenocarcinoma: sustained partial response on reduced-dose crizotinib after renal cysts

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: ALK gene translocation positive in >15% of tumor cells by FISH

As of June 2025, the lung cancer remained in partial response without progression on reduced-dose crizotinib, while crizotinib-associated renal cysts had markedly regressed.

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Metastatic colorectal cancer treated with chemotherapy, cytoreductive surgery and HIPEC

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: peritoneum, liver

She recovered sufficiently to be discharged home after cytoreductive surgery with HIPEC despite postoperative bone-marrow suppression, anastomotic dehiscence and pelvic sepsis.

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Ovarian cancer treated with chemotherapy and repeat pelvic surgery after recurrence

Patient Info: Anonymized, Female, Under 40

She improved after the repeat pelvic surgery and postoperative care and was discharged home.

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Stage IV HER2-Positive Breast Cancer: Jennifer's Survivor Story

Patient Info: Jennifer Masters, Female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Chest wall/skin near surgery incision; lymph nodes

As of May 2025, Jennifer had no reported recurrence for several years after Stage IV HER2-positive metastatic breast cancer responded completely to clinical-trial treatment with T-DM1 and neratinib; she continued annual Cleveland Clinic visits and remained active with family and volunteering.

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Metastatic colon cancer: soft-tissue and adrenal metastases responding to FOLFIRI plus bevacizumab

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type. CK20 and Ki-67 supported colorectal metastasis; CEA/CA19-9 were elevated.

Metastatic Site: lungs; left arm/biceps soft tissue; right…

As of May 2025, metastatic colon cancer involving soft tissue, muscle, lung history, and right adrenal gland had regressed after 12 months of FOLFIRI plus bevacizumab, and the patient was alive 1 year after chemotherapy completion.

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MSI-H locally advanced right colon cancer: pathologic complete response after oxaliplatin, capecitabine, and immunotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: MSI-H on tumor gene testing

After oxaliplatin, capecitabine, and sindilizumab conversion therapy followed by laparoscopic radical right hemicolectomy, postoperative pathology showed no viable tumor cells and tumor regression grade 0 complete response.

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Stage III Colorectal Cancer: James's Survivor Story

Patient Info: James, Male | Stage III

James had Stage IIIC / possible Stage IV rectal cancer with major lymph node involvement and an uncertain liver spot. After chemotherapy, radiation, multiple surgeries, permanent colostomy, and adjuvant chemotherapy, he later reported no evidence of disease.

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Stage III HR-Positive Invasive Lobular Carcinoma: Tanya's Patient Story

Patient Info: Tanya, Female, 40s | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; grade 1

As of May 2025, Tanya was recovering from chest wall surgery, ALT flap repair, and a later skin graft after developing angiosarcoma in her radiated reconstructed breast years after Stage IIIA ILC treatment.

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Stage I Gastric Cancer: Sarah's Survivor Story

Patient Info: Sarah Grace Beckham, Under 40 | Stage I

Biomarkers: CDH1 mutation

Five years after the gastrectomy, the patient reported remaining cancer-free and living a normal, active life.

MD AndersonRead more →