Stage I Pleomorphic Lung Cancer Recurring With Bone Metastasis Within Five Months
This lung cancer diagnosis at a glance
- Stage at diagnosis
- Stage IV
- Biomarkers
- PD-L1 high (TPS 80%); no detected driver mutation
- Sex
- male
- Spread to
- bone
- Treatment
- surgery, chemotherapy, immunotherapy and targeted therapy
- Outcome
- Responding Well
Treatment course, step by step
- Underwent left upper-lung resection for Stage I pleomorphic carcinoma in November 2023.
- Five months later, recurrence at the surgical site and a thoracic-spine bone metastasis were found, followed by further lung surgery in May 2024.
- Received 6 cycles of albumin-paclitaxel, gemcitabine, sintilimab and bevacizumab, with denosumab for the bone metastasis.
- Continued maintenance sintilimab and bevacizumab after achieving a partial response.
What happened, in summary
A 67-year-old man was evaluated in November 2023 after a small left upper-lung lesion was found during a physical examination. Surgery confirmed Stage I pulmonary pleomorphic carcinoma, a rare aggressive form of lung cancer. No driver mutation was detected.
Only 5 months after surgery, he developed cough and coughing up blood. Imaging showed a new mass at the surgical site and a metastasis in the third thoracic vertebra, establishing Stage IV recurrent disease. He underwent further lung surgery in May 2024. Testing of the recurrent tumor showed high PD-L1 expression at 80%.
After surgery, he received 6 cycles of albumin-paclitaxel and gemcitabine with the immunotherapy drug sintilimab and the anti-angiogenic drug bevacizumab. Denosumab was also given for the bone metastasis. The combination produced a partial response, confirmed on PET-CT in December 2024. As of February 2025, he was continuing maintenance sintilimab and bevacizumab, with about 9 months of progression-free survival after treatment for the recurrence.
Where this story comes from
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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Collections this story belongs to
- Stage 4 Lung Cancer 384 stories
- PD-L1 Positive Lung Cancer 21 stories
- Bevacizumab for Lung Cancer 37 stories
These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer