Stage IV Colorectal Cancer: Crystal's Survivor Story

Patient Info: Crystal, Female | Stage IV

Metastatic Site: Bladder involvement

As of May 2025, Crystal was living after major surgery for Stage IV colon cancer involving the bladder, with both colostomy and urostomy bags and an emphasis on mental health, support, and quality of life.

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Early-stage triple-negative breast cancer with separate lung carcinoid and later CML

Patient Info: Anonymized, Female, 50s

Biomarkers: triple negative

As of May 2025, serial follow-up breast ultrasound examinations showed no evidence of breast cancer recurrence in either breast tissue or axillary lymph nodes.

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Localized lung neuroendocrine tumor/carcinoid: wedge resection after surveillance

Patient Info: Anonymized, Female, 50s

Biomarkers: Well-differentiated neuroendocrine tumor, grade I; no lung molecular biomarkers reported

As of May 2025, the localized left lung carcinoid had remained stable during surveillance and was removed by thoracotomy with wedge resection; no lung metastasis was reported.

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Breast Cancer: Lourdes's Survivor Story

Patient Info: Lourdes del Río, Female

Biomarkers: Oncotype test performed; score/result not reported

As of May 2025, Lourdes described herself as cancer-free and 100% healthy, with a mammogram and ultrasound from the previous day coming out perfect.

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Metastatic Colorectal Cancer With NRG1 Fusion Controlled for Years With Afatinib

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: MATN-NRG1 fusion; no KRAS alteration detected

Afatinib controlled her metastatic colorectal cancer for 136 weeks. After resection of the remaining target lesion in September 2022, she remained alive with no progression as of October 2024.

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How We Got Here: 6 Young Lung Cancer Patients & Their Paths To Surgery- Part 1

Patient Info: Leah Phillips, Female | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: bone (pelvis; spine; ribs)

As of April 2025, Leah was living with Stage IV EGFR exon 19 deletion lung cancer while continuing Tagrisso after SBRT and right middle lobe lobectomy.

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Stage IV Colorectal Cancer: Albita's Patient Story

Patient Info: Albita, Female, Under 40 | Stage IV

Biomarkers: Described as wild type; no hereditary genetic marker reported

Metastatic Site: liver

Albita had Stage IV colon cancer with liver metastases. As of April 2025, the only active cancer she described was still in the liver, with 3 spots remaining after chemotherapy, radiation, liver resection, hysterectomy/colon surgery, ileostomy, and ongoing/planned liver-directed treatment.

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Stage IA ER/PR-positive breast cancer in SLE: arm-behind-back radiation after lumpectomy

Patient Info: Anonymized, Female, 40s | Stage I

Biomarkers: ER >95%; PR >95%; HER2 1+; Ki-67 23%; no BRCA1/2 variants identified

As of April 2025, 15 months after 3D conformal radiotherapy, she had no local recurrence, no distant metastasis, and no radiation pneumonitis.

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Rectal cancer recurring years later with perineural spread and distant metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: brain, lung, bone

Despite further chemotherapy, the cancer progressed to the brain, lungs and bones, and she died about 1 year later, approximately 9 years after her initial rectal-cancer treatment.

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HER2-Positive Breast Cancer With Brain and Leptomeningeal Metastases Responding to Intrathecal Treatment

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: brain, leptomeninges

More than 5 years after her September 2019 diagnosis, neurological symptoms had resolved, cerebrospinal fluid remained negative for tumor cells, and maintenance treatment was continuing in February 2025.

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Stage I Colorectal Cancer: Monica's Survivor Story

Patient Info: Monica Dean, Female, 40s | Stage I

As of April 2025, Monica was disease-free after Stage I colorectal cancer was removed with lower anterior resection; pathology showed clean margins and no lymph node involvement, and she did not need chemotherapy or radiation.

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Breast Cancer in a Woman Carrying Both BRCA1 and BRCA2 Mutations

Patient Info: Anonymized, Female | Stage I

Biomarkers: ER-positive, PR-positive, HER2-negative, BRCA1 pathogenic variant, BRCA2 pathogenic variant

Remained free of recurrence 17 months after treatment.

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Stage II Colorectal Cancer: Monica's Survivor Story

Patient Info: Monica Dean, Female, 40s | Stage II

Biomarkers: No genetic predisposition reported after testing

Monica Dean had Stage II colorectal cancer found by screening colonoscopy. Curative surgery showed clear margins and no lymph node involvement, so she did not need chemotherapy or radiation. As of April 2025, she was recovering with a temporary ileostomy and planning reversal.

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Lynch syndrome bifocal colon cancer: complete pathological remission after sintilimab

Patient Info: Anonymized, Male, 40s | Stage III

Biomarkers: Lynch-associated colon cancer with MSI-H and KRAS/NRAS/BRAF wild type; tumor markers were low or near normal.

As of April 2025, pathology after proximal colectomy showed tumor regression grade 0 with complete pathological remission, and follow-up found no recurrence or metastasis.

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Primary neuroendocrine breast tumor: disease-free 5 years after mastectomy and tamoxifen

Patient Info: Anonymized, Female, 50s

Biomarkers: Neuroendocrine breast tumor: ER/PR positive, HER2 negative

As of April 2025, she had remained disease-free for 5 years after mastectomy, negative sentinel lymph node biopsy, and tamoxifen 20 mg once daily.

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Michelle: Stage IV Colorectal Cancer

Patient Info: Michelle, Female, 40s | Stage IV

Metastatic Site: Ovary | Femoral nerve region

As of April 2025, Michelle described living as a Stage IV colorectal cancer survivor after FOLFOX, major surgery, 2.5 years with no evidence of disease, and a later PET-detected recurrence involving the femoral nerve region.

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Preoperative Stage IIB lung adenocarcinoma: no recurrence after robotic surgery

Patient Info: Anonymized, Female, 60s

As of April 2025, 6-month chest CT showed no recurrence after robotic right lower lobectomy and mediastinal lymph node dissection; no additional chemotherapy or radiation was reported.

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Stage IIA ER-positive breast cancer with axillary tuberculosis: no metabolically active disease after treatment

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: ER 78% positive; PR-negative; HER2/neu-negative; Ki-67 21%; Luminal A subtype

As of April 2025, follow-up PET-CT showed no metabolically active disease after mastectomy, adjuvant anthracycline-based chemotherapy, letrozole, and 6 months of anti-tuberculosis therapy.

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Metaplastic triple-negative breast cancer: near-complete response to taxane/carboplatin before surgery

Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced

Biomarkers: ER-negative; PR-negative; HER2-negative; CA 15-3 elevated, triple negative

As of April 2025, imaging after taxane/carboplatin showed a near-complete morpho-metabolic response in the right breast and major reduction of axillary nodal disease, followed by surgery and adjuvant chemotherapy/radiotherapy.

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HER2-amplified primary mucinous cystadenocarcinoma of the breast: surgery and adjuvant treatment

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: HER2-amplified / HER2 3+; ER/PR-negative; Ki-67 ~50%; p53 high; microsatellite stable. No clinically significant inherited mutation reported.

As of November 2024, she had more than 104 months of disease-free survival after breast-conserving surgery, sentinel lymph node biopsy, EC-T chemotherapy, and radiotherapy for Stage IIA HER2-amplified primary mucinous cystadenocarcinoma of the breast.

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Stage I HR-Positive Invasive Lobular Carcinoma: Mandy's Patient Story

Patient Info: Mandy, Female, 40s | Stage I

Biomarkers: ER-positive; PR-positive; low Oncotype score; genetic testing negative for 70 cancer-causing genes

As of April 2025, Mandy was about 10 months after bilateral mastectomy for Stage IA ER-positive, PR-positive ILC, had a low Oncotype score, was planning several years of tamoxifen, and was still in reconstruction.

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Stage IIIA double ALK-fusion lung adenocarcinoma: major pathological response to neoadjuvant alectinib

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: ALK-rearranged lung adenocarcinoma with both ELMOD3-ALK and EML4-ALK fusions. CEA/NSE/CA19-9 decreased after alectinib.

As of April 2025, he had continued alectinib for 4 years after surgery, with more than 48 months of disease-free survival, no recurrence, and no serious drug-related toxicity.

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Stage 0 Invasive Lobular Carcinoma: Kathleen's Survivor Story

Patient Info: Kathleen, Female | Stage 0

Kathleen completed surgery-focused treatment for DCIS with a very small invasive lobular component. No chemotherapy was needed, endocrine therapy was discussed but not required, and she continued imaging surveillance and advocacy in the flat community.

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Synchronous Stage I lung adenocarcinomas: VATS surgery with clear margins

Patient Info: Anonymized, Male, 70+

He completed surgical treatment with negative lymph nodes and clear margins, was discharged on postoperative day 9, and was planned for surveillance with his respiratory physician.

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