Lung Squamous Cell Carcinoma Found During Surgery for a Rare Lung Infection

Patient Info: Anonymized, male, 60s

Nine months after surgery, follow-up showed no recurrence of the lung cancer, the Mycobacterium malmoense infection, or new radiographic lung abnormalities.

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HER2-positive breast cancer with brain, skin, and lymph-node metastases responding to dual-targeted therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2-positive breast cancer. Initial tumor was ER/PR negative with Ki-67 30%; skin metastasis had Ki-67 70%.

Metastatic Site: brain, left cervical lymph nodes, skin of left chest…

After 1 cycle of inetetamab trastuzumab, pyrotinib, and capecitabine, skin metastases regressed, CEA and CA125 decreased, brain lesions shrank, and the largest lesion decreased by about 46%, meeting partial response; disease remained stable as of September 2024.

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I Was SHOCKED At My STAGE 4 Diagnosis!

Patient Info: Lauren, Female, 40s | Stage IV

Metastatic Site: peritoneum / abdominal cavity

Lauren was early in treatment for Stage IV signet-ring cell colon cancer. As of July 2025, she was receiving chemotherapy, living with a colostomy, and hoping for enough response to allow further surgery or HIPEC; remission was not stated.

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Kate Joyal

Patient Info: Kate Joyal | Stage IV

After 8 rounds of chemotherapy and colorectal surgery, Kate reported clear follow-up scans and remained hopeful about becoming cancer-free.

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Stage III Triple-Negative Breast Cancer: Lynn's Survivor Story

Patient Info: Lynn Leiro, Female, Under 40 | Stage III

Biomarkers: ER-negative; PR-negative; HER2-negative

Lynn achieved complete response after breast cancer treatment and remission from therapy-related acute lymphocytic leukemia after CAR T cell therapy and bone marrow transplant; as of July 2025, nearly 1 year post-transplant, she was doing better and getting stronger.

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Isolated adrenal metastasis from breast cancer: adrenalectomy and exemestane plus palbociclib

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; GATA3-positive; CK7-positive; mammaglobin-positive; GCDFP-15 rare staining

Metastatic Site: right adrenal gland

After laparoscopic right adrenalectomy for isolated metastatic breast carcinoma, follow-up CT abdomen/pelvis and PET-CT showed no metastatic disease elsewhere; surveillance while on exemestane and palbociclib showed no recurrence so far.

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Recovering From a Severe Immune Side Effect During Breast Cancer Treatment

Patient Info: Anonymized, Female, 60s

Recovered from the severe immune-related nerve and muscle complication and proceeded to breast cancer surgery; at 8 months she had returned to normal daily function.

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Stage IV Colorectal Adenocarcinoma: Lauren's Patient Story

Patient Info: Lauren, Female, 40s | Stage IV

Biomarkers: No actionable biomarkers reported; tumor testing suggested Lynch syndrome/hereditary pattern was unlikely; germline genetic testing pending

Lauren had Stage IV signet-ring cell colon cancer diagnosed after obstruction and emergency surgery with colostomy. As of July 2025, she was receiving traditional colorectal chemotherapy and awaiting germline genetic testing; remission was not stated.

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ER/PR-positive breast cancer with separate solitary rib plasmacytoma: disease-free after breast and plasmacytoma treatment

Patient Info: Anonymized, Female, 60s

Biomarkers: Breast cancer: ER-positive, PR-positive, HER2-negative

More than 5 years after treatment, she remained disease-free with no recurrence of either ER/PR-positive breast cancer or the separate solitary rib plasmacytoma.

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Stage IIIA EGFR lung adenocarcinoma: no recurrence after early osimertinib stop

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: EGFR exon 19 deletion mutation; elevated KL-6 and SP-D during interstitial lung disease episode

During 9 months of follow-up after osimertinib was stopped, she had no recurrence of interstitial lung disease, pulmonary embolism, or non-small cell lung cancer.

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Stage IIIB triple-negative breast cancer: complete response after LVAD-supported neoadjuvant immunotherapy

Patient Info: Anonymized, Female, 60s | Stage III

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 95%; nuclear grade 3, triple negative

As of July 2025, breast cancer remained in remission 2.5 years after mastectomy, after neoadjuvant paclitaxel/carboplatin/pembrolizumab, surgery, radiation, and 1 year of adjuvant pembrolizumab.

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HER2-Positive Pleomorphic Lobular Breast Cancer in a 43-Year-Old Woman

Patient Info: Anonymized, Female, 40s

Biomarkers: HER2-positive, ER-negative, PR-negative

Postoperative adjuvant treatment continued with HER2-targeted therapy after chemotherapy and radiation.

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Primary perianal Paget disease: clear margins and disease-free 2-year follow-up after local excision

Patient Info: Anonymized, Male

Biomarkers: Cytokeratin 7 strongly positive; immunohistology suggestive of primary perianal Paget disease

At 2-year follow-up, he remained disease-free after wide local excision with clear margins, temporary defunctioning colostomy, delayed flap closure, and later colostomy reversal.

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Stage 4 triple-negative breast cancer: NED after adrenalectomy

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative; CA 15-3 elevated at recurrence; normalized post-surgery

Metastatic Site: adrenal gland

After adrenalectomy, serum CA15-3 and metanephrine/normetanephrine levels normalized, and the preoperative workup had found no other metastatic disease.

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HER2-low lobular breast cancer with bone marrow involvement responding to T-DXd

Patient Info: Anonymized, Female | Stage IV

Biomarkers: Initial surgical specimen: ER-positive; PR-negative; HER2-negative. Bone marrow relapse: breast cancer infiltration with low HER2 staining.

Metastatic Site: bone marrow

Two years after starting T-DXd, this patient remained free of bone marrow disease and continued the same treatment regimen.

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HER2-low lobular breast cancer with bone marrow involvement treated with T-DXd

Patient Info: Anonymized, Female | Stage IV

Biomarkers: Initial surgical specimen: ER-positive; PR-negative; HER2-negative. Bone marrow relapse: breast cancer infiltration with low HER2 staining.

Metastatic Site: bone marrow

Two years after starting T-DXd, this patient remained free of bone marrow disease and continued the same treatment regimen.

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Stage IIIA squamous lung cancer with pathologic complete response after immunochemotherapy

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: PD-L1 TPS 90%; PD-L1 CPS 100%; EGFR p.G719S 24.9%; EGFR p.S768I 24.6%; TP53 p.S183* 7.2%; TMB 0.0 Muts/Mb

Systematic imaging in March 2025 showed no recurrence or metastasis, with postoperative disease-free survival longer than 30 months and overall survival longer than 34 months.

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Breast cancer survivorship: radiation-related esophageal stricture and H. heilmannii gastritis treated after therapy

Patient Info: Anonymized, Female, 70+

Biomarkers: Breast tumor biomarkers not reported; initial gastric biopsies H. pylori-negative; repeat gastric biopsies showed H. heilmannii organisms

After completing breast cancer surgery and chemoradiotherapy, post-treatment dysphagia and gastritis resolved with esophageal dilation, proton pump inhibitor therapy, and bismuth-based quadruple therapy for H. heilmannii.

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Stage IVA lung adenosquamous carcinoma: complete response after paclitaxel, nedaplatin, and tislelizumab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Adenosquamous lung cancer markers; PD-L1 TPS 18%; KRAS, BRAF, PIK3CA, FLT1 mutation; TMB 3.7

Metastatic Site: pleura/chest wall, cervical lymph nodes, axillary…

As of March 30, 2025, he maintained complete response with normal tumor markers, no radiologic evidence of progression or recurrence, and progression-free survival of 46.5 months after paclitaxel/nedaplatin/tislelizumab followed by maintenance tislelizumab.

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Stage II Colorectal Cancer: Andrea's Patient Story

Patient Info: Andrea Suarez V | Stage II

Nearly 9 years later, Andrea described herself as a survivor and advocate for culturally appropriate colorectal cancer care.

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Stage II EGFR Lung Cancer: Samantha's Patient Story

Patient Info: Samantha Vaughn, Female | Stage II

Biomarkers: EGFR mutation

Samantha had Stage II EGFR-mutated lung cancer removed surgically and was receiving post-operative daily Tagrisso through a clinical trial. As of June 2025, she reported clear results so far but remained on active targeted therapy.

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Stage III HR-Positive Invasive Lobular Carcinoma: Courtney's Patient Story

Patient Info: Courtney, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative

As of June 2025, Courtney was recovering from Stage III ER-positive, PR-positive, HER2-negative ILC treatment after double mastectomy, Taxotere/Cytoxan chemotherapy, and 25 rounds of radiation, with reconstructive surgery delayed by radiation skin injury.

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Stage 4 colorectal cancer: complete response with panitumumab and FOLFOX4

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF wild type; MSS/pMMR; HER2 not overexpressed. CEA and CA19-9 were elevated.

Metastatic Site: periaortic and pelvic lymph nodes; left ovary/adnexa

As of November 2024, she was alive and continuing second-line FOLFIRI with stable disease after prior complete remission on panitumumab plus FOLFOX4 and later progression with ovarian metastasis.

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Stage III Colorectal Cancer: Paige's Patient Story

Patient Info: Paige Cipher, Female, Under 40 | Stage III

Paige had Stage III rectal cancer and was still in treatment. After 6 rounds of chemotherapy, the tumor had shrunk but was not gone; as of June 2025, she had just completed round 7, had 1 more round planned, and expected surgery in about 3 weeks.

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