Stage IV gastric cancer complicated by a fractured gastric outlet stent

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: peritoneum

He died while receiving palliative care 10 months after emergency surgery for a fractured-stent complication.

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Treatment-related lung injury during therapy for Stage IV squamous lung cancer

Patient Info: Anonymized, Male, 60s | Stage IV

A 63-year-old man with Stage IV squamous lung cancer developed interstitial lung disease soon after starting chemotherapy and immunotherapy, with respiratory findings improving after steroid treatment.

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Stage IV BRAF Colorectal Cancer: Sophie's Survivor Story

Patient Info: Sophie, Female | Stage IV

Biomarkers: BRAF-mutated; MSI / microsatellite instability

Metastatic Site: liver; lymph nodes including neck

As of June 2024, Sophie had been off treatment for nearly 3 years and described herself as currently cancer-free after surgery, chemotherapy, immunotherapy, and liver surgery showing no cancer cells.

The Patient StoryRead more →

Eye complication (corneal irritation) as a rare side effect of nivolumab immunotherapy

Patient Info: Anonymized, Female

One year after nivolumab was stopped, there was no progression of the lung cancer or secondary lesions, and she remained under surveillance.

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SMARCA4-deficient undifferentiated lung cancer with pleural disease and later spinal metastasis

Patient Info: Anonymized, male, 40s | Stage IV

Biomarkers: BRCA1 p.S1796 variant; TP53 p.; tumor mutational burden 12.6

Metastatic Site: spine

After chemotherapy and one cycle of nivolumab, a new 4.5 cm spinal metastasis caused cord compression and required surgery; further outpatient treatment was planned.

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Metastatic gastric cancer with Krukenberg tumors complicated by emergency bleeding

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: bilateral ovaries/adnexa (Krukenberg tumors)

She recovered well from emergency surgery for bleeding from a torsed Krukenberg tumor and was attending regular oncology follow-up 6 months later.

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Fatal lung-cancer progression after immune-related HLH during nivolumab and ipilimumab

Patient Info: Anonymized, male, 40s | Stage IV

Metastatic Site: pleura, lung

The immune-related HLH improved with steroid pulse therapy, but he later died from respiratory failure caused by progression of the lung cancer.

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Stage IV lung adenocarcinoma complicated by immunotherapy-related perimyocarditis

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: EGFR-negative; ALK-negative; ROS1-negative; PD-L1 <1%

She died from cancer progression 3 months after recovering from immunotherapy-related perimyocarditis.

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Lung squamous cell cancer treated with chemotherapy and nivolumab alongside IgG4-related disease

Patient Info: Anonymized, male, 70+

Biomarkers: PD-L1 TPS 65%

Nivolumab was stopped after disease progression, and he died from progressive lung cancer 17 months later.

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Metastatic gastric cancer with an ATM mutation responding to olaparib

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: Pathogenic germline ATM mutation, HER2-negative, PD-L1 15%

Metastatic Site: peritoneum

He had a deep response lasting about 18 months, but imaging in December 2023 again showed peritoneal carcinomatosis.

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Brain radiation therapy complication (radionecrosis) potentially linked to combined chemo-immunotherapy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: PD-L1 0%; tumour mutational burden 33 mutations/Mb; TP53 mutation at diagnosis; later ctDNA included KEAP1 and NOTCH3 alterations

Metastatic Site: brain; presumed leptomeningeal disease

She recovered completely from surgery for radiation necrosis, resumed cancer treatment and remained neurologically intact at 18 months. She was found deceased 9 months later; the cause of death was unknown.

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Stage I Ovarian Cancer: Elle's Patient Story

Patient Info: Elle Simone Scott, Female, Under 40 | Stage I

Living with recurrent ovarian cancer for more than 6 years after her September 2016 diagnosis, with an active clinical trial slowing progression at the May 2023 publication.

Dana-FarberRead more →

Stage III Ovarian Cancer: Karoline's Patient Story

Patient Info: Karoline Strauss, female | Stage III

After resuming etigilimab and nivolumab, the patient felt markedly better; by the eighth infusion, some tumors had disappeared and others were shrinking, and treatment was continuing.

MD AndersonRead more →

Stage IV gastric cancer with liver metastases cleared after chemotherapy, nivolumab and surgery

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: PD-L1-positive, HER2-negative

Metastatic Site: liver

After treatment cleared the gastric and liver lesions, all anticancer therapy was stopped. He remained relapse-free with no evidence of disease for 32 months.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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A young man with metastatic rectal cancer and inherited BRCA1 and MLH1 mutations

Patient Info: Anonymized, Male, Under 40 | Stage IV

Biomarkers: Germline BRCA1 c.4065_4068delTCAA and MLH1 c.232G>T mutations; tumor microsatellite instability-high; loss of MLH1 and PMS2 expression; elevated tumor mutational burden; loss of heterozygosity of wild-type MLH1.

Metastatic Site: liver

The rectal and liver tumors showed a partial response, no viable carcinoma was found in the resected liver lesions, and maintenance nivolumab continued without evidence of growth or recurrence.

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Stage IV Colorectal Cancer: Cindi's Survivor Story

Patient Info: Cindi, Female, 60s | Stage IV

Metastatic Site: Liver; abdominal lining/peritoneum

As of March 2022, Cindi had no recurrence more than 1 year after a clinical trial with nivolumab, investigational anti-tumor vaccine, chemotherapy, and surgery produced a complete pathologic response with no living cancer cells.

Cleveland ClinicRead more →

Long-term complete response to nivolumab after recurrent Stage IV gastric cancer

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: HER2-negative, PD-L1 CPS ≤1

Metastatic Site: peritoneum, distant lymph nodes

About 7 years after surgery and roughly 3 years after starting nivolumab, CT showed no recurrent nodules or enlarged lymph nodes. She remained on nivolumab with a complete clinical response, had regained weight and returned to work.

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Metastatic Clear Cell Ovarian Cancer Complicated by Treatment-Related Sarcoidosis

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Metastatic Site: peritoneum

During a treatment holiday, biopsy and laboratory evaluation showed treatment-related sarcoidosis rather than ovarian-cancer spread in the enlarged lymph nodes. After prednisone, the sarcoidosis resolved and imaging showed no progression of the clear cell ovarian cancer; she remained clinically well 4 months later.

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Kidney Injury During Nivolumab Treatment for Stage IV Gastric Cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Kidney function and proteinuria improved after nivolumab was stopped, but the gastric cancer progressed. Restarted nivolumab was ineffective, and treatment was changed to irinotecan.

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A Severe Delayed Immune Reaction After Treatment for Metastatic Colon Cancer

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver

He recovered from repeated episodes of severe cytokine release syndrome after prolonged corticosteroids, completed adjuvant FOLFOX and CV301 without nivolumab, and had no further CRS episodes.

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Metastatic NRG1-Fusion Lung Cancer Responding to Long-Term Afatinib

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Biomarkers: CD74-NRG1 fusion

Metastatic Site: lungs

As of February 2020, she remained on afatinib 30 mg daily with an ongoing partial response after 27 months.

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Recurrent NRG1-Fusion Lung Cancer After Surgery and Immunotherapy

Patient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced

Biomarkers: SDC4-NRG1 fusion

He chose no further treatment after rapid progression on afatinib and died shortly afterward in hospice.

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Stage IV Mucinous Lung Cancer Treated With Afatinib and Surgery

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: CD74-NRG1 fusion; ALK/ROS1/EGFR/BRAF/KRAS/MET/HER2 wild type; PD-L1 initially not expressed and later 0%-20%

Metastatic Site: bilateral lungs|bone|right adrenal gland

She was alive and receiving treatment after bone and right-adrenal progression at the latest follow-up.

PubMed CentralRead more →