Stage IV gastric cancer complicated by a fractured gastric outlet stent

This gastric cancer diagnosis at a glance

Stage at diagnosis
Stage IV
Sex
Male
Spread to
peritoneum
Treatment
chemotherapy, targeted therapy, immunotherapy and palliative care
Outcome
In Memory

Treatment course, step by step

  1. Received FOLFOX for unresectable Stage IV gastric cancer.
  2. After progression, received weekly paclitaxel plus ramucirumab.
  3. Chemotherapy was restarted after recovery from surgery for a fractured-stent complication.
  4. Received nivolumab after further disease progression.
  5. Later received palliative care.

What happened, in summary

A 65-year-old man was diagnosed with unresectable gastric cancer involving the lower stomach with peritoneal spread. He began FOLFOX chemotherapy, but the primary tumor progressed after three months and caused nausea and vomiting from gastric outlet obstruction. An uncovered metal stent was placed to reopen the narrowed outlet.

He then received weekly paclitaxel plus ramucirumab. Three months later, he again developed nausea and vomiting. Imaging showed that the stent had fractured and a segment had migrated into the small bowel, causing obstruction. Surgeons removed the migrated stent segment and created a jejunostomy. A month later, the stoma was closed and a gastrojejunostomy was created. By two months after the emergency surgery, he could eat solid food without intravenous fluids and chemotherapy was restarted.

When the gastric cancer progressed again, he received nivolumab. He later transitioned to palliative care and died 10 months after the emergency surgery.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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