Cancer Stories
Breast CancerRare Breast Neuroendocrine Cancer That Recurred in the Liver
Patient Info: Anonymized, Female, 70+ | Stage IV
Biomarkers: Chromogranin-positive; synaptophysin-positive; GATA-3-positive; ER-positive; PR negative on repeat biopsy and 40% positive on the mastectomy specimen; HER2-negative; Ki-67 85–95%
Metastatic Site: Liver; abdominal lymph nodes
Lung CancerPatient Info: Anonymized, Male, 50s
Biomarkers: No molecular biomarkers reported for SCLC. Bladder biopsy during cystitis showed mostly CD3/CD8-positive T-cell inflammation.
Lung CancerSmall Cell Lung Cancer: Montessa's Survivor Story
Patient Info: Montessa, Female, Under 40
Lung CancerPatient Info: Anonymized, Male, 60s
Biomarkers: CSF positive for anti-NMDAR antibodies; no tumor molecular biomarkers reported
Lung CancerPatient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced
Biomarkers: ProGRP and NSE were elevated at diagnosis. Tumor molecular biomarkers were not reported; diabetes antibodies were negative.
Metastatic Site: left submandibular region / adjacent lymph nodes
Lung CancerExtensive-stage small-cell lung cancer with malignant superior vena cava syndrome
Patient Info: Anonymized, Male, 60s
Colorectal CancerLarge-Cell Neuroendocrine Cancer of the Cecum in Familial Adenomatous Polyposis
Patient Info: Anonymized, female
Biomarkers: Pathogenic germline APC mutation; KRAS ; PALB2 mutation; microsatellite stable with intact mismatch-repair proteins
Breast CancerLocalized male small-cell neuroendocrine breast cancer with complete response
Patient Info: Anonymized, Male, 40s
Biomarkers: Synaptophysin-positive; weak cytokeratin-positive; HER2-negative; Ki-67 greater than 70%; genetic testing not performed
Ovarian CancerOvarian Cancer Metastatic to an Axillary Lymph Node Without Breast Disease
Patient Info: Anonymized, female, 50s | Stage IV
Biomarkers: BRCA1/2 negative
Metastatic Site: right axillary lymph node
Lung CancerPatient Info: Anonymized, Female, 60s | Stage IV
Metastatic Site: bone (axial skeleton and skull)
Lung CancerSmall Cell Lung Cancer After a Remote Chest Gunshot Injury
Patient Info: Anonymized, male
Ovarian CancerYoung Woman With Rare Small Cell Ovarian Cancer and Abdominal Recurrence
Patient Info: Anonymized, female, Under 40 | Stage III
Biomarkers: loss of SMARCA4 expression; retained SMARCB1 expression
Lung CancerPatient Info: Anonymized, Male, 60s | Stage IV
Biomarkers: Small-cell lung cancer markers included TTF-1/chromogranin-A with Ki-67 90%. Paraneoplastic testing showed GABA-B receptor IgG positive.
Metastatic Site: adrenal glands, diaphragmatic lymph nodes, lungs,…
Lung CancerFour EGFR-Mutated Lung Cancers That Changed Form After Osimertinib
Patient Info: Anonymized, female, 50s
Biomarkers: EGFR exon 19 deletion; TP53 p.D259V
Lung CancerFour EGFR-Mutated Lung Cancers That Changed Form After Osimertinib — Case 2
Patient Info: Anonymized, female, 60s
Biomarkers: EGFR exon 19 deletion; TP53 p.R110P; acquired MET amplification
Lung CancerExtensive-stage small-cell lung cancer with serplulimab-associated diabetes: care ongoing
Patient Info: Anonymized, Male, 60s | Stage IV
Biomarkers: Tumor biomarkers not reported. Diabetes workup after immunotherapy: autoantibodies negative, C-peptide very low.
Lung CancerExtensive-stage small-cell lung cancer with serplulimab-associated diabetes
Patient Info: Anonymized, Male, 70+ | Stage IV
Biomarkers: Tumor biomarkers not reported. Diabetes autoantibodies were negative, C-peptide was low, and hypothyroidism labs were severe.
Ovarian CancerRare Ovarian Neuroendocrine Cancer Treated With Surgery and Chemotherapy
Patient Info: Anonymized, female, 40s
Biomarkers: somatic BRCA2 mutation; MSI-H; high tumor mutational burden; germline BRCA2 negative
Lung CancerExtensive-stage small-cell lung cancer with immune-related diabetes and stable disease at 2 years
Patient Info: Anonymized, Female, 60s | Stage IV
Biomarkers: Tumor PD-L1 not reported. Immune-related diabetes showed very low C-peptide and negative diabetes autoantibodies; thyroiditis also occurred.
Metastatic Site: pancreas; pleura/pleural effusion; mediastinal lymph…
Lung CancerPatient Info: Anonymized, Male, 70+ | Stage IV
Biomarkers: PD-L1 <1%
Metastatic Site: bone (C2, T10, sacral vertebrae); malignant pleural…
Lung CancerPatient Info: Anonymized, Male, 40s
Biomarkers: PD-L1 CPS 1
Lung CancerPatient Info: Anonymized, Female, 50s | Stage IV
Biomarkers: especially at recurrence. PD-L1 was not reported.
Metastatic Site: liver; right hilar and mediastinal lymph nodes
Lung CancerPatient Info: Anonymized, Male, 50s | Stage IV
Biomarkers: Small-cell lung cancer markers included CD56, CgA and TTF-1; Ki-67 was 80%.
Metastatic Site: brain, right adrenal gland, left adrenal gland
Lung CancerLimited-stage small cell lung cancer with no recurrence after 14 years
Patient Info: Anonymized, Female, 60s
Biomarkers: SCLC markers: CD56/TTF-1 positive. Essential thrombocythemia had JAK2 . Cancer predisposition gene testing was negative.