Breast cancer recurrence involving the bladder and bones

Patient Info: Anonymized, Female | Stage IV

Biomarkers: Initial breast cancer: ER-positive, PR-positive, HER2-negative. Bladder metastasis: ER-positive, PR-negative, HER2 1+.

Metastatic Site: bladder, bone, rectosigmoid region, anorectal region

She died in October 2016 from pulmonary haemorrhage, 47 months after metastatic disease was diagnosed.

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Gastric cancer diagnosed after pregnancy-related symptoms and gastric perforation

Patient Info: Anonymized, Female, Under 40 | Stage IV

CT after chemotherapy showed a good response, but her condition later deteriorated with multiple thromboses associated with metastatic disease. She died a few months after diagnosis.

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What It’s Like When Your Dad Has Breast Cancer

Patient Info: Anonymized

She was a six-year breast cancer survivor.

Dana-FarberRead more →

Metastatic colon cancer in a woman later diagnosed with Lynch syndrome

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Pathogenic germline MLH1 p. mutation; Lynch syndrome

Metastatic Site: liver

Twenty years after the metastatic colon cancer treatment, she presented with a separate small-bowel adenocarcinoma rather than recurrent colon cancer. Follow-up imaging 6 months after treatment of that later cancer showed no evidence of neoplastic disease.

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Teenage colon cancer initially mistaken for anorexia nervosa

Patient Info: Anonymized, Female, Under 40 | Stage III

Biomarkers: Loss of MSH2 and MSH6 expression; microsatellite instability; MSH2 variant of uncertain significance suspected to affect splicing; Lynch syndrome diagnosis

She remained in remission 3 years after surgery.

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Breast cancer spreading to the colon, rectum and peritoneal surfaces

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary tumor: ER >80% positive; PR 50–60% positive; HER2 negative; E-cadherin positive. Later colorectal metastases: ER positive; PR negative; HER2 negative; CK7 positive; CK20 negative; CDX2 negative.

Metastatic Site: colon, rectum, peritoneum, diaphragm, liver, bowel,…

Metastatic breast cancer was subsequently confirmed in the colon and rectum, with later laparoscopic biopsies showing peritoneal and additional intra-abdominal metastatic disease.

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Locally advanced transverse colon cancer complicated by a colocutaneous fistula

Patient Info: Anonymized, Female, 60s | Stage III

After initially recovering from surgery, she developed a respiratory infection, sepsis and metabolic encephalopathy and died after cardiorespiratory arrest on postoperative day 12.

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Autoimmune hemolytic anemia after 39 cycles of nivolumab for metastatic lung cancer

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver, bone

While nivolumab remained on hold, his lung cancer was stable on imaging and clinically, and hemoglobin had recovered to 14.6 g/dL about 4 months after high-dose prednisone and rituximab began.

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Metastatic lung cancer causing recurrent small-bowel intussusception

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EGFR mutation; exon 19 deletion in metastatic bowel lesions

Metastatic Site: small bowel

She recovered satisfactorily after bowel surgery, and care shifted to palliation with long-term nutritional support planned.

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Occult lobular breast cancer presenting as an orbital metastasis

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER positive; PR positive; HER2 negative; CK7 positive; CK CAM5.2 positive; E-cadherin negative

Metastatic Site: left orbit, bone

The orbital metastasis decreased with treatment and systemic disease remained controlled on hormonal therapy during 5 years of clinical follow-up.

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Colorectal cancer discovered during treatment for Klebsiella endophthalmitis

Patient Info: Anonymized, Male, 60s | Stage II

Post-treatment pathology showed Stage II rectal adenocarcinoma, with a synchronous sigmoid adenocarcinoma also identified.

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Employees' own cancer treatment shapes how they give back

Patient Info: Jamie Bernard, female, Under 40 | Stage II

After mastectomy and chemotherapy, Jamie became active in patient and caregiver support programs at MD Anderson.

MD AndersonRead more →

Stage IV Ovarian Cancer: Janelle's Patient Story

Patient Info: Janelle Kister, female | Stage IV

Treatment ended, and Janelle was still doing well 17 years after her Stage IV ovarian cancer diagnosis.

MD AndersonRead more →

Colon cancer chemotherapy complicated by a severe manic episode

Patient Info: Anonymized, Male, 40s | Stage III

He completed chemotherapy without further affective episodes on the revised regimen and remained under regular follow-up.

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Stage III Colorectal Cancer: Annie's Patient Story

Patient Info: Annie Schreiber, Female, Under 40 | Stage III

As of March 2018, Annie had recovered from TaTME surgery with a temporary ileostomy instead of a permanent colostomy and was undergoing chemotherapy with a very good prognosis.

Cleveland ClinicRead more →

Stage IV gastric cancer with peritoneal metastases responds to combined chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, Under 40 | Stage IV

Metastatic Site: peritoneum

At last follow-up in January 2018, she was asymptomatic and examinations showed no evidence of disease.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: peritoneum

Developed peritoneal recurrence 3 months after postoperative chemotherapy and was receiving second-line chemotherapy at follow-up.

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Stage IV gastric adenocarcinoma progresses despite multiple chemotherapy approaches for peritoneal metastases

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: peritoneum

The cancer progressed during second-line treatment, and he died from tumor-related complications in April 2017, about 16 months after his December 2015 admission.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, gastrectomy and HIPEC

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: peritoneum

At follow-up, he had no signs of recurrence.

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Stage II metaplastic breast cancer in a 47-year-old man

Patient Info: Anonymized, Male, 40s | Stage II

Biomarkers: ER 1%; PR negative; HER2 negative; E-cadherin positive; p63 positive; genetic testing reported no abnormal mutations

Two years after surgery he was doing well, with only occasional pain at the mastectomy site and a negative recent mammogram of the left breast.

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Breast Cancer: Heather's Survivor Story

Patient Info: Heather Kokinda, Female, Under 40

As of March 2018, Heather had completed chemotherapy and double mastectomy, had a clear scan before trying to conceive again, and had given birth to another daughter in July 2017.

Cleveland ClinicRead more →

Robotic gastric cancer surgery in a man with situs inversus totalis and no recurrence at 2.5 years

Patient Info: Anonymized, Male, 50s

Biomarkers: HER2 2+

At 2.5 years after surgery, there was no recurrence.

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Rectal cancer treatment followed by a rare rectovaginal fistula

Patient Info: Anonymized, Female, 60s

After fistula repair and later ileostomy closure, she remained fully continent despite 5–10 liquid bowel movements per day.

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Stage IV ovarian cancer presenting as a persistent umbilical ulcer

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: bilateral cardiophrenic lymph nodes

She recovered from extensive cytoreductive surgery without major abdominal or pulmonary complications and began adjuvant paclitaxel and carboplatin on postoperative day 25.

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