Metastatic gastric neuroendocrine carcinoma treated with repeated chemotherapy and immunotherapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver, pancreas

More than 3 years after diagnosis, he remained in good condition on fifth-line treatment. April 2023 CT showed shrinkage of liver and pancreatic-tail metastases.

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Localized Linitis Plastica With Gastric Amyloidosis Followed by Multiple Myeloma

Patient Info: Anonymized, Female

Biomarkers: CA19-9: 47.5 U/mL

She remained in clinical remission for 3 years after gastric cancer treatment, and later CT imaging showed no recurrent gastric disease when multiple myeloma was diagnosed.

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Solitary adrenal metastasis after surgery for gastric large-cell neuroendocrine carcinoma

Patient Info: Anonymized, male | Stage IV

Metastatic Site: right adrenal gland

Nine months after removal of the adrenal metastasis, he was alive and August 2022 CT showed no new metastases or tumor recurrence.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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Gastric adenocarcinoma diagnosed alongside a separate retroperitoneal liposarcoma

Patient Info: Anonymized, male

He died 3.5 months after admission from hepatorenal failure in the setting of severe jaundice caused by the rapidly progressive retroperitoneal liposarcoma. Autopsy showed gastric adenocarcinoma with regional lymph-node involvement but no distant organ metastasis from the gastric cancer.

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Long-term complete response to nivolumab after recurrent Stage IV gastric cancer

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: HER2-negative, PD-L1 CPS ≤1

Metastatic Site: peritoneum, distant lymph nodes

About 7 years after surgery and roughly 3 years after starting nivolumab, CT showed no recurrent nodules or enlarged lymph nodes. She remained on nivolumab with a complete clinical response, had regained weight and returned to work.

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Stage IV gastric cancer treated with chemotherapy and hyperthermia in a patient with a vagus nerve stimulator

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: para-aortic lymph nodes, peritoneum

The gastric tumors and lymph-node disease initially shrank during treatment, but peritoneal dissemination developed. He died from progressive gastric cancer 8 months after treatment began.

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Sjögren syndrome during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, lungs, adrenal gland

One year after nivolumab was stopped, the shrinkage of lung metastases was maintained and the adrenal metastasis remained unchanged, although severe dry-mouth symptoms from treatment-related Sjögren syndrome persisted.

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Graves disease during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, brain

After progression through several treatment lines and development of brain metastasis, he died 4 months after evaluation for nivolumab-associated Graves disease, more than 1.5 years after his Stage IV gastric-cancer diagnosis.

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Chemotherapy and Surgery for Recurrent Oesophagogastric Junction Cancer

Patient Info: Anonymized, Male

The recurrent tumor was completely removed after chemotherapy. Two years after the second operation, he remained well with no recurrence.

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Gastric Cancer Metastasis to the Hand Treated With Radiation

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Metastatic Site: liver|adrenal glands|left hand bones

Radiation relieved the hand pain and swelling and restored movement. At 6 months, he remained alive and pain-free in the hand, while the underlying metastatic gastric cancer remained present.

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Stage IV gastric cancer complicated by paraneoplastic dermatomyositis during nivolumab treatment

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: liver, lung, abdominal cavity

He died from rapidly worsening gastric cancer 142 days after the first nivolumab dose, roughly 14 months after his April 2017 diagnosis.

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Mixed adenocarcinoma-neuroendocrine gastric cancer progressing after multiple treatments

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver

After progression through several treatments and development of liver metastasis, he was taking apatinib at the latest update.

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Mucinous gastric cancer presenting with an iris metastasis

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: iris, peritoneum, para-aortic and mesenteric lymph…

She died of aspiration pneumonia 8 months after presentation. Autopsy confirmed persistent invasive gastric cancer with metastatic spread.

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Hereditary diffuse gastric cancer in a 34-year-old man with a CDH1 mutation

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: CDH1 monoallelic deletion of exons 1-2

Under surveillance with the most recent CT showing no active disease and no evidence of disease at the latest follow-up.

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Stage IV gastric cancer with peritoneal metastases responds to combined chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, Under 40 | Stage IV

Metastatic Site: peritoneum

At last follow-up in January 2018, she was asymptomatic and examinations showed no evidence of disease.

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Stage IV signet-ring gastric cancer with peritoneal metastases treated with chemotherapy, surgery and HIPEC

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: peritoneum

Developed peritoneal recurrence 3 months after postoperative chemotherapy and was receiving second-line chemotherapy at follow-up.

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Stage IV gastric adenocarcinoma progresses despite multiple chemotherapy approaches for peritoneal metastases

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: peritoneum

The cancer progressed during second-line treatment, and he died from tumor-related complications in April 2017, about 16 months after his December 2015 admission.

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Recurrent Gastric Cancer With Peritoneal Spread and Acute Hypertension During Ramucirumab

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: peritoneum

Treatment was stopped after 2 cycles because of progression, no further cytotoxic treatment was started, and he died at home 19 weeks after the last chemotherapy.

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Gastric cancer recurs in the spermatic cord 7 years after treatment

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: epididymis, spermatic cord

At 26 months after orchiectomy, he was doing well with no evidence of recurrence, more than 9 years after his original gastric-cancer surgery.

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Gastric cancer recurs in the spermatic cord after 6 years without recurrence

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: spermatic cord

At 20 months after orchiectomy, he was stable with no recurrence, more than 7 years after treatment of his original gastric cancer.

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Gastric adenocarcinoma recurs in the adrenal gland 6 years after gastrectomy

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: left adrenal gland

At 13 months after resection of the adrenal metastasis, imaging and tumor-marker follow-up found no evidence of recurrence, placing him more than 7 years beyond the original gastrectomy.

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Signet-ring gastric cancer with repeated recurrences and a late adrenal metastasis

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: left adrenal gland

At 12 months after resection of the adrenal metastasis, no definite recurrence was found, roughly 7 years after the original gastric-cancer surgery.

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Gastric adenocarcinoma spreads to the liver and esophageal mucosa

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver, esophageal mucosa

The metastatic disease progressed despite 3 cycles of second-line docetaxel plus cisplatin.

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