Capecitabine for Gastric Cancer: 15 Real Stories

ALK-Fusion Gastric Cancer Responds to Alectinib Before Progression

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: DCTN1–ALK fusion; ATM p.E1724*; CDK6 amplification; HER2 negative; mismatch-repair proteins intact; later KRAS amplification

Metastatic Site: bone

Alectinib produced a partial response for about 11.5 months, but the cancer later progressed systemically and she died from uncontrollable gastrointestinal bleeding.

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Gastric Cancer Treatment Interrupted by Capecitabine-Related Brain Toxicity

Patient Info: Anonymized, Female | Stage II

Her cognition and vital signs improved over several days after capecitabine was stopped. At follow-up 2 weeks later, chemotherapy remained suspended and the treatment plan was revised to radiation alone.

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Recurrent gastric cancer with bone metastases, venous thrombosis and chylothorax

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: bone

Biopsy-confirmed bone recurrence developed more than a year after surgery. He was too unwell for palliative chemotherapy and died a few months after transition to best supportive care.

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Stage IV gastric adenocarcinoma first detected through an appendiceal metastasis

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: appendix

He was referred to oncology for Stage IV gastric cancer and started capecitabine chemotherapy.

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Stage II Gastric Cancer: Sagan's Patient Story

Patient Info: Sagan | Stage II

Sagan reported completing cancer treatment and continued taking medicines for treatment-related symptoms while focusing on recovery.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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Ramucirumab and paclitaxel for metastatic gastric cancer in a patient receiving hemodialysis

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver, distant lymph nodes

After about 16 months of disease control on paclitaxel plus ramucirumab, multiple liver metastases and distant lymph nodes progressed. Third-line irinotecan was stopped after severe toxicity, and supportive care followed.

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Sjögren syndrome during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, lungs, adrenal gland

One year after nivolumab was stopped, the shrinkage of lung metastases was maintained and the adrenal metastasis remained unchanged, although severe dry-mouth symptoms from treatment-related Sjögren syndrome persisted.

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Cutaneous lymphatic spread after Stage III gastric cancer with signet-ring cells

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: bone, distant lymph nodes, skin

After metastatic spread to bone, distant lymph nodes and skin, she developed respiratory failure and died despite palliative treatment.

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Stage IV gastric cancer presenting with chylothorax and lymphedema

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: distant lymph nodes, pleura, peritoneum

She died 6 months after the Stage IV gastric-cancer diagnosis despite chemotherapy and repeated treatment of the malignant pleural effusions.

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Gastric Cancer Metastasis to the Hand Treated With Radiation

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Metastatic Site: liver|adrenal glands|left hand bones

Radiation relieved the hand pain and swelling and restored movement. At 6 months, he remained alive and pain-free in the hand, while the underlying metastatic gastric cancer remained present.

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Mixed adenocarcinoma-neuroendocrine gastric cancer progressing after multiple treatments

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver

After progression through several treatments and development of liver metastasis, he was taking apatinib at the latest update.

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Perforated gastric cancer treated with staged surgery, HIPEC and chemotherapy

Patient Info: Anonymized, male, 60s

Adjuvant capecitabine plus oxaliplatin began one month after surgery. At the 6-month follow-up, he was eating without discomfort and had no other symptoms.

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Metastatic Gastric Cancer Treatment Complicated by Acute Hypertension During Ramucirumab

Patient Info: Anonymized, male, 60s

After progression on first-line chemotherapy, he had started second-line ramucirumab-based treatment when an acute hypertensive infusion reaction was documented.

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Recurrent Gastric Cancer With Peritoneal Spread and Acute Hypertension During Ramucirumab

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: peritoneum

Treatment was stopped after 2 cycles because of progression, no further cytotoxic treatment was started, and he died at home 19 weeks after the last chemotherapy.

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