Sjögren syndrome during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, lungs, adrenal gland

One year after nivolumab was stopped, the shrinkage of lung metastases was maintained and the adrenal metastasis remained unchanged, although severe dry-mouth symptoms from treatment-related Sjögren syndrome persisted.

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Dural metastasis causing seizures after treatment for signet-ring gastric cancer

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: dura mater

She died 16 days after hospital admission for neurologic symptoms, roughly 8 months after the original gastric-cancer diagnosis, following rapid deterioration from diffuse dural metastatic disease.

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Graves disease during nivolumab treatment for HER2-positive metastatic gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, brain

After progression through several treatment lines and development of brain metastasis, he died 4 months after evaluation for nivolumab-associated Graves disease, more than 1.5 years after his Stage IV gastric-cancer diagnosis.

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Chemotherapy and Surgery for Recurrent Oesophagogastric Junction Cancer

Patient Info: Anonymized, Male

The recurrent tumor was completely removed after chemotherapy. Two years after the second operation, he remained well with no recurrence.

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Cutaneous lymphatic spread after Stage III gastric cancer with signet-ring cells

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: bone, distant lymph nodes, skin

After metastatic spread to bone, distant lymph nodes and skin, she developed respiratory failure and died despite palliative treatment.

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Nivolumab-related IgA kidney disease during treatment for Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

The gastric tumor regrew while nivolumab was withheld. Kidney function improved with steroids, but recurrent pneumonia and poor performance status prevented immunotherapy from restarting.

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Portal-vein thrombosis after surgery and chemotherapy for Stage III gastric cancer — Case 1

Patient Info: Anonymized, female, 40s | Stage III

At 6 months of follow-up after treatment for the thrombosis, no hepatic decompensation or liver cirrhosis had developed.

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Portal-vein thrombosis after surgery and chemotherapy for Stage III gastric cancer — Case 2

Patient Info: Anonymized, female, 60s | Stage III

Two months into follow-up after the thrombosis, no hepatic decompensation or liver cirrhosis had been identified.

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Stage IV Gastric Cancer: Faye's Patient Story

Patient Info: Faye Hood, female, 70+ | Stage IV

After surgery and heated intraperitoneal chemotherapy, Faye recovered, returned to exercise and completed a half-marathon 1 year later.

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Gastric cancer diagnosed during late pregnancy after severe gastrointestinal bleeding

Patient Info: Anonymized, female, 40s

Biomarkers: HER2-negative

Six months after emergency surgery, chemotherapy and radiation were still ongoing.

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Gastric cancer with an unexpected appendix metastasis

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: appendix

PET/CT at 6, 12 and 18 months showed no recurrence, giving at least 18 months with no evidence of disease after treatment.

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Clival skull-base metastasis during treatment for Stage IV gastric cancer

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: HER2-negative

Metastatic Site: peritoneum, cervical lymph nodes, pelvic bone, lungs,…

At publication he was alive on fourth-line treatment, with no disease progression for 6 months after the clival metastasis was treated and with sustained improvement in his cranial-nerve symptoms.

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Stage III Gastric Cancer: Abdul's Patient Story

Patient Info: Abdul | Stage III

Abdul later stopped further treatment and focused on spending meaningful time with family while living with gastric cancer.

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Stage I Gastric Adenocarcinoma: Kaisu's Survivor Story

Patient Info: Kaisu, female | Stage I

Kaisu reported being cancer-free since November 2020 after chemotherapy and total gastrectomy, while continuing to manage lasting treatment and surgery effects.

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Severe reversible neurologic toxicity after apatinib for metastatic gastric cancer

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: bone, adrenal glands

At follow-up in April 2019, he was alive and independent about 7 years after his Stage IV diagnosis, with apatinib permanently stopped after the neurologic toxicity.

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Stage IV gastric cancer presenting with chylothorax and lymphedema

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: distant lymph nodes, pleura, peritoneum

She died 6 months after the Stage IV gastric-cancer diagnosis despite chemotherapy and repeated treatment of the malignant pleural effusions.

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Reversible Heart Dysfunction After FLOT Chemotherapy for Gastric Cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Her speech recovered within hours and heart function returned to an ejection fraction of 65% within 1 week. Gastric-cancer treatment continued with carboplatin and paclitaxel.

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Gastric Cancer Metastasis to the Hand Treated With Radiation

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Metastatic Site: liver|adrenal glands|left hand bones

Radiation relieved the hand pain and swelling and restored movement. At 6 months, he remained alive and pain-free in the hand, while the underlying metastatic gastric cancer remained present.

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Primary gastric squamous cell carcinoma with early chest metastases

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: lungs, distant lymph nodes

Twelve months after chemotherapy began, the metastatic chest lesions had not progressed and showed minor regression.

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Stage IV gastric cancer complicated by paraneoplastic dermatomyositis during nivolumab treatment

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: liver, lung, abdominal cavity

He died from rapidly worsening gastric cancer 142 days after the first nivolumab dose, roughly 14 months after his April 2017 diagnosis.

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Mixed adenocarcinoma-neuroendocrine gastric cancer progressing after multiple treatments

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver

After progression through several treatments and development of liver metastasis, he was taking apatinib at the latest update.

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Metastatic gastric cancer with suspected spread to an extraocular muscle

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: ovary, mesentery, neck subcutaneous tissue, thoracic…

She died 3 months after the eye presentation, more than 2 years after the gastric-cancer diagnosis.

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Mucinous gastric cancer presenting with an iris metastasis

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: iris, peritoneum, para-aortic and mesenteric lymph…

She died of aspiration pneumonia 8 months after presentation. Autopsy confirmed persistent invasive gastric cancer with metastatic spread.

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Perforated gastric cancer treated with staged surgery, HIPEC and chemotherapy

Patient Info: Anonymized, male, 60s

Adjuvant capecitabine plus oxaliplatin began one month after surgery. At the 6-month follow-up, he was eating without discomfort and had no other symptoms.

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